Impact of early postoperative blood glucose variability on serum endocan level in cardiac surgery patients: a sub study of the ENDOLUNG observational study.
Cardiac surgery
Endocan
Endothelial function
Glycemic variability
Journal
Cardiovascular diabetology
ISSN: 1475-2840
Titre abrégé: Cardiovasc Diabetol
Pays: England
ID NLM: 101147637
Informations de publication
Date de publication:
24 08 2023
24 08 2023
Historique:
received:
06
06
2023
accepted:
12
08
2023
medline:
28
8
2023
pubmed:
25
8
2023
entrez:
24
8
2023
Statut:
epublish
Résumé
Early postoperative glycemic variability is associated with worse outcome after cardiac surgery, but the underlying mechanisms remain unknown. This study aimed to describe the relationship between postoperative glycemic variability and endothelial function, as assessed by serum endocan level in cardiac surgery patients. We performed a post hoc analysis of patients included in the single-center observational ENDOLUNG study. Adult patients who underwent planned isolated coronary artery bypass graft surgery were eligible. Postoperative glycemic variability was assessed by calculating the coefficient of variability (CV) of blood glucose measured within 24 (CV Data from 177 patients were analyzed. Median CV Early postoperative glycemic variability within 48 h after planned cardiac surgery does not appear to be correlated with postoperative serum endocan level. NCT02542423.
Sections du résumé
BACKGROUND
Early postoperative glycemic variability is associated with worse outcome after cardiac surgery, but the underlying mechanisms remain unknown. This study aimed to describe the relationship between postoperative glycemic variability and endothelial function, as assessed by serum endocan level in cardiac surgery patients.
METHODS
We performed a post hoc analysis of patients included in the single-center observational ENDOLUNG study. Adult patients who underwent planned isolated coronary artery bypass graft surgery were eligible. Postoperative glycemic variability was assessed by calculating the coefficient of variability (CV) of blood glucose measured within 24 (CV
RESULTS
Data from 177 patients were analyzed. Median CV
CONCLUSIONS
Early postoperative glycemic variability within 48 h after planned cardiac surgery does not appear to be correlated with postoperative serum endocan level.
CLINICAL TRIAL REGISTRATION NUMBER
NCT02542423.
Identifiants
pubmed: 37620974
doi: 10.1186/s12933-023-01959-5
pii: 10.1186/s12933-023-01959-5
pmc: PMC10464002
doi:
Substances chimiques
Blood Glucose
0
Banques de données
ClinicalTrials.gov
['NCT02542423']
Types de publication
Observational Study
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
221Informations de copyright
© 2023. BioMed Central Ltd., part of Springer Nature.
Références
Kh C, Cj JO, Jj L, Se P, Ms L. In-hospital glycemic variability and all-cause mortality among patients hospitalized for acute heart failure. Cardiovasc Diabetol. 2022;21(1):291.
doi: 10.1186/s12933-022-01720-4
Besch G, Pili-Floury S, Morel C, Gilard M, Flicoteaux G, Salomon du Mont L, et al. Impact of post-procedural glycemic variability on cardiovascular morbidity and mortality after transcatheter aortic valve implantation: a post hoc cohort analysis. Cardiovasc Diabetol. 2019;18(1):27.
doi: 10.1186/s12933-019-0831-3
pubmed: 30857532
pmcid: 6410509
Subramaniam B, Lerner A, Novack V, Khabbaz K, Paryente-Wiesmann M, Hess P, et al. Increased glycemic variability in patients with elevated preoperative HbA1C predicts adverse outcomes following coronary artery bypass grafting surgery. Anesth Analg. 2014;118(2):277–87.
doi: 10.1213/ANE.0000000000000100
pubmed: 24445629
Su Y, Fan W, Liu Y, Hong K. Glycemic variability and in-hospital death of critically ill patients and the role of ventricular arrhythmias. Cardiovasc Diabetol. 2023;22(1):134.
doi: 10.1186/s12933-023-01861-0
pubmed: 37308889
pmcid: 10258982
Monnier L, Mas E, Ginet C, Michel F, Villon L, Cristol JP, et al. Activation of oxidative stress by acute glucose fluctuations compared with sustained chronic hyperglycemia in patients with type 2 diabetes. JAMA. 2006;295(14):1681–7.
doi: 10.1001/jama.295.14.1681
pubmed: 16609090
Sun B, Luo Z, Zhou J. Comprehensive elaboration of glycemic variability in diabetic macrovascular and microvascular complications. Cardiovasc Diabetol. 2021;20(1):9.
doi: 10.1186/s12933-020-01200-7
pubmed: 33413392
pmcid: 7792304
Taya N, Katakami N, Mita T, Okada Y, Wakasugi S, Yoshii H, et al. Associations of continuous glucose monitoring-assessed glucose variability with intima-media thickness and ultrasonic tissue characteristics of the carotid arteries: a cross-sectional analysis in patients with type 2 diabetes. Cardiovasc Diabetol. 2021;20(1):95.
doi: 10.1186/s12933-021-01288-5
pubmed: 33947398
pmcid: 8097791
Chen J, Jiang L, Yu XH, Hu M, Zhang YK, Liu X, et al. Endocan: a key player of Cardiovascular Disease. Front Cardiovasc Med. 2021;8:798699.
doi: 10.3389/fcvm.2021.798699
pubmed: 35071362
De Freitas Caires N, Gaudet A, Portier L, Tsicopoulos A, Mathieu D, Lassalle P. Endocan, sepsis, pneumonia, and acute respiratory distress syndrome. Crit Care Lond Engl. 2018;22(1):280.
doi: 10.1186/s13054-018-2222-7
Perrotti A, Chenevier-Gobeaux C, Ecarnot F, Bardonnet K, Barrucand B, Flicoteaux G, et al. Is Endocan a diagnostic marker for Pneumonia after Cardiac surgery? The ENDOLUNG Study. Ann Thorac Surg. 2018;105(2):535–41.
doi: 10.1016/j.athoracsur.2017.07.031
pubmed: 29132699
Ziaee M, Mashayekhi S, Ghaffari S, Mahmoudi J, Sarbakhsh P, Garjani A. Predictive value of Endocan based on TIMI Risk score on major adverse Cardiovascular events after Acute Coronary Syndrome. Angiology. 2019;70(10):952–9.
doi: 10.1177/0003319718815241
pubmed: 30514091
Zhang J. Biomarkers of endothelial activation and dysfunction in cardiovascular diseases. Rev Cardiovasc Med. 2022;23(2):73.
doi: 10.31083/j.rcm2302073
pubmed: 35229564
Balamir I, Ates I, Topcuoglu C, Turhan T. Association of Endocan, Ischemia-Modified albumin, and hsCRP levels with endothelial dysfunction in type 2 diabetes Mellitus. Angiology. 2018;69(7):609–16.
doi: 10.1177/0003319717740781
pubmed: 29172652
Akboga MK, Okutucu S, Sabanoglu C, Yayla C, Ertem AG, Efe TH. Are Endocan and Ischemia-Modified Albumin Reliable biomarkers for endothelial dysfunction in type 2. Diabetes Mellitus? Angiology. 2020;71(5):479–80.
pubmed: 29874919
Leite AR, Borges-Canha M, Cardoso R, Neves JS, Castro-Ferreira R, Leite-Moreira A. Novel biomarkers for evaluation of endothelial dysfunction. Angiology. 2020;71(5):397–410.
doi: 10.1177/0003319720903586
pubmed: 32077315
Reina-Couto M, Silva-Pereira C, Pereira-Terra P, Quelhas-Santos J, Bessa J, Serrão P, et al. Endothelitis profile in acute heart failure and cardiogenic shock patients: Endocan as a potential novel biomarker and putative therapeutic target. Front Physiol. 2022;13:965611.
doi: 10.3389/fphys.2022.965611
pubmed: 36035482
pmcid: 9407685
Bouglé A, Allain PA, Favard S, Ait Hamou N, Carillion A, Leprince P, et al. Postoperative serum levels of Endocan are associated with the duration of norepinephrine support after coronary artery bypass surgery. Anaesth Crit Care Pain Med. 2018;37(6):565–70.
doi: 10.1016/j.accpm.2018.02.013
pubmed: 29476941
Benincasa G, Coscioni E, Napoli C. Cardiovascular risk factors and molecular routes underlying endothelial dysfunction: novel opportunities for primary prevention. Biochem Pharmacol. 2022;202:115108.
doi: 10.1016/j.bcp.2022.115108
pubmed: 35643340
Buscemi S, Re A, Batsis JA, Arnone M, Mattina A, Cerasola G, et al. Glycaemic variability using continuous glucose monitoring and endothelial function in the metabolic syndrome and in type 2 diabetes. Diabet Med J Br Diabet Assoc. 2010;27(8):872–8.
doi: 10.1111/j.1464-5491.2010.03059.x
Ceriello A, Esposito K, Piconi L, Ihnat MA, Thorpe JE, Testa R, et al. Oscillating glucose is more deleterious to endothelial function and oxidative stress Than Mean glucose in normal and type 2 Diabetic patients. Diabetes. 2008;57(5):1349–54.
doi: 10.2337/db08-0063
pubmed: 18299315
Mućka S, Miodońska M, Jakubiak GK, Starzak M, Cieślar G, Stanek A. Endothelial function Assessment by Flow-Mediated Dilation Method: A Valuable Tool in the evaluation of the Cardiovascular System. Int J Environ Res Public Health. 2022;19(18):11242.
doi: 10.3390/ijerph191811242
pubmed: 36141513
pmcid: 9517126
Minhas AS, Goerlich E, Corretti MC, Arbab-Zadeh A, Kelle S, Leucker T, et al. Imaging Assessment of endothelial function: an index of Cardiovascular Health. Front Cardiovasc Med. 2022;9:778762.
doi: 10.3389/fcvm.2022.778762
pubmed: 35498006
pmcid: 9051238
Studer C, Sankou W, Penfornis A, Pili-Floury S, Puyraveau M, Cordier A, et al. Efficacy and safety of an insulin infusion protocol during and after cardiac surgery. Diabetes Metab. 2010;36(1):71–8.
doi: 10.1016/j.diabet.2009.05.008
pubmed: 20097589
Besch G, Perrotti A, Salomon du Mont L, Tucella R, Flicoteaux G, Bondy A, et al. Long-term compliance with a validated intravenous insulin therapy protocol in cardiac surgery patients: a quality improvement project. Int J Qual Health Care. 2018;30(10):817–22.
doi: 10.1093/intqhc/mzy112
pubmed: 29788110
Jacobi J, Bircher N, Krinsley J, Agus M, Braithwaite SS, Deutschman C, et al. Guidelines for the use of an insulin infusion for the management of hyperglycemia in critically ill patients. Crit Care Med. 2012;40(12):3251–76.
doi: 10.1097/CCM.0b013e3182653269
pubmed: 23164767
Duncan AE, Abd-Elsayed A, Maheshwari A, Xu M, Soltesz E, Koch CG. Role of intraoperative and postoperative blood glucose concentrations in predicting outcomes after cardiac surgery. Anesthesiology. 2010;112(4):860–71.
doi: 10.1097/ALN.0b013e3181d3d4b4
pubmed: 20216389
Arman Y, Akpinar TS, Kose M, Emet S, Yuruyen G, Akarsu M, et al. Effect of glycemic regulation on endocan levels in patients with diabetes: a preliminary study. Angiology. 2016;67(3):239–44.
doi: 10.1177/0003319715585664
pubmed: 25969567
Lv Y, Zhang Y, Shi W, Liu J, Li Y, Zhou Z, et al. The Association between Endocan levels and subclinical atherosclerosis in patients with type 2 diabetes Mellitus. Am J Med Sci. 2017;353(5):433–8.
doi: 10.1016/j.amjms.2017.02.004
pubmed: 28502328
Qiu C, Sui J, Zhang Q, Wei P, Wang P, Fu Q. Relationship of endothelial cell-specific molecule 1 level in stress hyperglycemia patients with Acute ST-Segment Elevation myocardial infarction: a pilot study. Angiology. 2016;67(9):829–34.
doi: 10.1177/0003319715621996
Qiu CR, Fu Q, Sui J, Zhang Q, Wei P, Wu Y, et al. Serum endothelial cell-specific molecule 1 (endocan) levels in patients with Acute myocardial infarction and its clinical significance. Angiology. 2017;68(4):354–9.
doi: 10.1177/0003319716651349
pubmed: 27225701
Huang Y, Yue L, Qiu J, Gao M, Liu S, Wang J. Endothelial dysfunction and platelet hyperactivation in Diabetic Complications Induced by Glycemic Variability. Horm Metab Res. 2022;54(7):419–28.
doi: 10.1055/a-1880-0978
pubmed: 35835141
pmcid: 9282943
Mitchell JD, Grocott HP, Phillips-Bute B, Mathew JP, Newman MF, Bar-Yosef S. Cytokine secretion after cardiac surgery and its relationship to postoperative fever. Cytokine. 2007;38(1):37–42.
doi: 10.1016/j.cyto.2007.04.009
pubmed: 17572096
Takahashi H, Iwahashi N, Kirigaya J, Kataoka S, Minamimoto Y, Gohbara M, et al. Glycemic variability determined with a continuous glucose monitoring system can predict prognosis after acute coronary syndrome. Cardiovasc Diabetol. 2018;17(1):116.
doi: 10.1186/s12933-018-0761-5
pubmed: 30121076
pmcid: 6098663