Composite Hydrogels with Embedded Silver Nanoparticles and Ibuprofen as Wound Dressing.
antibacterial activity
chitosan/PVA hydrogels
ibuprofen
silver nanoparticles
wound healing
Journal
Gels (Basel, Switzerland)
ISSN: 2310-2861
Titre abrégé: Gels
Pays: Switzerland
ID NLM: 101696925
Informations de publication
Date de publication:
14 Aug 2023
14 Aug 2023
Historique:
received:
18
07
2023
revised:
02
08
2023
accepted:
11
08
2023
medline:
25
8
2023
pubmed:
25
8
2023
entrez:
25
8
2023
Statut:
epublish
Résumé
The wound healing process is often slowed down as a result of complications from bacterial infections and inflammatory reactions. Therefore, it is necessary to develop dressings with fast antibacterial and anti-inflammatory activity that shorten the wound healing period by promoting cell migration and proliferation. Chitosan (CS)-based hydrogels have been widely studied for their antibacterial and wound healing capabilities. Herein, we developed a composite hydrogel based on CS and PVA embedding silver nanoparticles (AgNPs) with antibacterial properties and ibuprofen (Ib) as an anti-inflammatory agent. The hydrogel prepared by double physical cross-linking, with oxalic acid and by freeze-thawing, loaded with 0.225 wt.% AgNPs and 0.264 wt.% Ib, displayed good mechanical properties (compressive modulus = 132 kPa), a high swelling degree and sustained drug delivery (in simulated skin conditions). Moreover, the hydrogel showed strong antibacterial activity against
Identifiants
pubmed: 37623109
pii: gels9080654
doi: 10.3390/gels9080654
pmc: PMC10454181
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Romanian Ministry of Education and Research
ID : PN-III-P2-2.1-PED-2019-1780
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