Soluble Transferrin Receptor as Iron Deficiency Biomarker: Impact on Exercise Capacity in Heart Failure Patients.
6 min walking test (6MWT)
Minnesota Living with Heart Failure Questionnaire (MLHFQ)
heart failure
iron deficiency
quality of life
soluble transferrin receptor
submaximal functional capacity
Journal
Journal of personalized medicine
ISSN: 2075-4426
Titre abrégé: J Pers Med
Pays: Switzerland
ID NLM: 101602269
Informations de publication
Date de publication:
21 Aug 2023
21 Aug 2023
Historique:
received:
09
07
2023
revised:
05
08
2023
accepted:
18
08
2023
medline:
25
8
2023
pubmed:
25
8
2023
entrez:
25
8
2023
Statut:
epublish
Résumé
The soluble transferrin receptor (sTfR) is a marker of tissue iron status, which could indicate an increased iron demand at the tissue level. The impact of sTfR levels on functional capacity and quality of life (QoL) in non-anemic heart failure (HF) patients with otherwise normal systemic iron status has not been evaluated. We conducted an observational, prospective, cohort study of 1236 patients with chronic HF. We selected patients with normal hemoglobin levels and normal systemic iron status. Tissue iron deficiency (ID) was defined as levels of sTfR > 75th percentile (1.63 mg per L). The primary endpoints were the distance walked in the 6 min walking test (6MWT) and the overall summary score (OSS) of the Minnesota Living with Heart Failure Questionnaire (MLHFQ). The final study cohort consisted of 215 patients. Overall QoL was significantly worse (51 ± 27 vs. 39 ± 20,
Identifiants
pubmed: 37623532
pii: jpm13081282
doi: 10.3390/jpm13081282
pmc: PMC10455097
pii:
doi:
Types de publication
Journal Article
Langues
eng
Déclaration de conflit d'intérêts
The authors declare that they have no conflict of interest relevant to the contents of this manuscript.
Références
Circulation. 2022 May 3;145(18):e895-e1032
pubmed: 35363499
Eur Heart J. 2013 Mar;34(11):816-29
pubmed: 23100285
Am J Cardiol. 2016 Jan 15;117(2):233-9
pubmed: 26686573
Heart Fail Rev. 2019 Mar;24(2):269-277
pubmed: 30284070
Blood. 1990 May 1;75(9):1870-6
pubmed: 2331526
Circulation. 2021 Jun;143(22):2129-2142
pubmed: 33906372
Am J Respir Crit Care Med. 2002 Jul 1;166(1):111-7
pubmed: 12091180
BMC Cardiovasc Disord. 2018 Nov 1;18(1):206
pubmed: 30382817
Acta Cardiol. 2018 Apr;73(2):115-123
pubmed: 28730869
Eur Heart J. 2021 Aug 17;42(31):3011-3020
pubmed: 34080008
Int J Cardiol. 2015 Feb 15;181:120-6
pubmed: 25497534
J Am Heart Assoc. 2019 Feb 19;8(4):e010887
pubmed: 30760082
Rev Esp Cardiol. 2008 Mar;61(3):251-9
pubmed: 18361898
JAMA. 1993 Oct 13;270(14):1702-7
pubmed: 8411500
J Gastrointestin Liver Dis. 2009 Sep;18(3):345-52
pubmed: 19795030
J Clin Med. 2020 Apr 22;9(4):
pubmed: 32331365
Eur J Prev Cardiol. 2021 Dec 29;28(15):1647-1649
pubmed: 33624061
Eur Heart J. 2015 Mar 14;36(11):657-68
pubmed: 25176939
Lancet. 2020 Dec 12;396(10266):1895-1904
pubmed: 33197395
Cell Biosci. 2021 May 17;11(1):89
pubmed: 34001233
J Clin Med. 2021 Oct 26;10(21):
pubmed: 34768457
Am J Kidney Dis. 2001 Jan;37(1 Suppl 1):S182-238
pubmed: 11229970
JACC Heart Fail. 2019 Jan;7(1):36-46
pubmed: 30553903
Diabetes Care. 2013 Dec;36(12):4147-56
pubmed: 24130349
Am J Clin Nutr. 2004 Mar;79(3):437-43
pubmed: 14985219
Ann Phys Rehabil Med. 2014 Jun;57(4):244-53
pubmed: 24835160
Blood. 1998 Oct 15;92(8):2934-9
pubmed: 9763580
Tex Heart Inst J. 2007;34(2):166-9
pubmed: 17622362
Eur J Heart Fail. 2021 Jun;23(6):919-932
pubmed: 33111457
Int J Cardiol. 2019 Feb 1;276:171-176
pubmed: 30409739
Eur J Intern Med. 2020 Oct;80:91-98
pubmed: 32439287
Rev Esp Cardiol (Engl Ed). 2016 Mar;69(3):247-55
pubmed: 26684058
Int J Cardiol. 2012 Aug 9;159(1):47-52
pubmed: 21899903
BMC Cardiovasc Disord. 2016 Aug 30;16(1):163
pubmed: 27577747
ESC Heart Fail. 2023 Apr;10(2):1090-1102
pubmed: 36582154
Clin J Am Soc Nephrol. 2006 Sep;1 Suppl 1:S4-8
pubmed: 17699374
Eur J Heart Fail. 2016 Sep;18(9):1132-40
pubmed: 27108481
J Clin Med. 2021 Dec 27;11(1):
pubmed: 35011874
N Engl J Med. 2009 Dec 17;361(25):2436-48
pubmed: 19920054
Eur J Heart Fail. 2021 Jan;23(1):92-113
pubmed: 32392403
Ther Adv Cardiovasc Dis. 2019 Jan-Dec;13:1753944719870084
pubmed: 31441375
Eur J Heart Fail. 2020 Nov;22(11):2038-2046
pubmed: 32155309
Clin Res Cardiol. 2021 Aug;110(8):1299-1307
pubmed: 33755777
Eur Heart J. 2013 Jan;34(1):30-8
pubmed: 22297124
Am J Hematol. 2008 Nov;83(11):872-5
pubmed: 18821709
Eur Heart J. 2010 Aug;31(15):1872-80
pubmed: 20570952
Int J Nurs Stud. 2022 May;129:104233
pubmed: 35349970
Eur J Cardiovasc Nurs. 2022 Mar 3;21(2):116-126
pubmed: 34008849
Eur J Heart Fail. 2013 Oct;15(10):1164-72
pubmed: 23703106
Eur J Heart Fail. 2022 Jan;24(1):4-131
pubmed: 35083827
Int J Cardiol. 2019 Feb 15;277:250-257
pubmed: 30413306
J Card Fail. 2011 Nov;17(11):899-906
pubmed: 22041326
J Am Heart Assoc. 2020 May 5;9(9):e015480
pubmed: 32321351
Eur J Prev Cardiol. 2021 Dec 29;28(15):1639-1646
pubmed: 33619543
Int J Cardiol. 2014 Jun 15;174(2):268-75
pubmed: 24768464
Eur J Heart Fail. 2018 May;20(5):910-919
pubmed: 29484788
J Patient Rep Outcomes. 2022 Jan 15;6(1):6
pubmed: 35032226
Circ Heart Fail. 2018 Feb;11(2):e004519
pubmed: 29382661