Disseminated Cryptococcosis Is a Common Finding among Human Immunodeficiency Virus-Infected Patients with Suspected Sepsis and Is Associated with Higher Mortality Rates.
Africa
HIV
blood culture
cryptococcal infection
qSOFA
sepsis
Journal
Journal of fungi (Basel, Switzerland)
ISSN: 2309-608X
Titre abrégé: J Fungi (Basel)
Pays: Switzerland
ID NLM: 101671827
Informations de publication
Date de publication:
09 Aug 2023
09 Aug 2023
Historique:
received:
22
05
2023
revised:
31
07
2023
accepted:
03
08
2023
medline:
25
8
2023
pubmed:
25
8
2023
entrez:
25
8
2023
Statut:
epublish
Résumé
Cryptococcosis is the leading cause of death among people with HIV in Sub-Saharan Africa. The lack of optimum diagnoses and medications significantly impair the management of the disease. We investigated the burden of cryptococcosis and related mortality among people with HIV and suspected sepsis in Ethiopia. We conducted a prospective study at (1) Adama Hospital Medical College and (2) Asella Referral and Teaching Hospital from September 2019 to November 2020. We enrolled adult, HIV-infected patients presenting with suspected sepsis and assessed their 28-day survival rates. We performed blood cultures and cryptococcal antigen (CrAg) testing. In total, 82 participants were enrolled with a median age of 35 years, and 61% were female. Overall, eleven (13%) had positive CrAg tests, of which five grew
Identifiants
pubmed: 37623607
pii: jof9080836
doi: 10.3390/jof9080836
pmc: PMC10456031
pii:
doi:
Types de publication
Journal Article
Langues
eng
Références
BMC Infect Dis. 2021 Aug 10;21(1):786
pubmed: 34376147
JAMA. 2016 Feb 23;315(8):801-10
pubmed: 26903338
HIV Med. 2019 Jan;20(1):69-73
pubmed: 30311440
Front Cell Infect Microbiol. 2021 Jun 23;11:695240
pubmed: 34249782
Virulence. 2016 Apr 2;7(3):320-8
pubmed: 26950194
Clin Infect Dis. 2023 Feb 18;76(4):764-770
pubmed: 35986670
Jpn J Infect Dis. 2012;65(1):28-32
pubmed: 22274154
Nat Rev Microbiol. 2022 Sep;20(9):557-571
pubmed: 35352028
PLoS One. 2021 Mar 4;16(3):e0247646
pubmed: 33661970
BMC Infect Dis. 2020 Feb 14;20(1):141
pubmed: 32059703
Lancet. 2015 May 30;385(9983):2173-82
pubmed: 25765698
Lancet Glob Health. 2022 Dec;10(12):e1845-e1854
pubmed: 36400090
Clin Infect Dis. 2017 Nov 29;65(12):2126-2129
pubmed: 29020172
Open Forum Infect Dis. 2018 May 24;5(8):ofy122
pubmed: 30094292
Clin Infect Dis. 2016 Mar 1;62(5):581-587
pubmed: 26565007
J Acquir Immune Defic Syndr. 2019 Feb 1;80(2):205-213
pubmed: 30422904
Clin Infect Dis. 2021 Dec 15;73(Suppl_5):S343-S350
pubmed: 34910173
Lancet Infect Dis. 2022 Dec;22(12):1748-1755
pubmed: 36049486
Int J Infect Dis. 2020 Jul;96:276-283
pubmed: 32289564
J Acquir Immune Defic Syndr. 2014 Jun 1;66(2):e31-6
pubmed: 24675586
J Thorac Dis. 2017 Apr;9(4):943-945
pubmed: 28523143
Front Med (Lausanne). 2022 Sep 08;9:989265
pubmed: 36160163
J Clin Microbiol. 2019 Jan 2;57(1):
pubmed: 30257903
Antimicrob Resist Infect Control. 2022 Jan 15;11(1):8
pubmed: 35033191
JAMA. 2016 Feb 23;315(8):762-74
pubmed: 26903335
Emerg Infect Dis. 2014 Jan;20(1):45-53
pubmed: 24378231