Use of Dichlorodimethylsilane to Produce Polydimethylsiloxane as a Substitute for Vitreous Humour: Characteristics and In Vitro Toxicity.
DCM
DCMS
PDMS
high viscosity
hydrolysis–condensation
in vitro toxicity
medium viscosity
optimization
ratio
Journal
Journal of functional biomaterials
ISSN: 2079-4983
Titre abrégé: J Funct Biomater
Pays: Switzerland
ID NLM: 101570734
Informations de publication
Date de publication:
15 Aug 2023
15 Aug 2023
Historique:
received:
24
05
2023
revised:
14
06
2023
accepted:
28
06
2023
medline:
25
8
2023
pubmed:
25
8
2023
entrez:
25
8
2023
Statut:
epublish
Résumé
Polydimethylsiloxane (PDMS) is a substitute for vitreous humour in vitreoretinal surgery and is usually produced from octamethylcyclotetrasiloxane (D4). In Indonesia, both commercial PDMS and D4 are limited and expensive. Dichlorodimethylsilane (DCMS) can be an alternative to produce PDMS. DCMS is cheaper and easier to obtain than D4. However, more extra effort is needed in order to produce PDMS from DCMS. Therefore, this study aimed to produce PDMS from DCMS by varying the ratio of DCMS precursor to dichloromethane (DCM) solvent at ratios of 1:1 and 1:4 through the hydrolysis-condensation method under neutral conditions. The PDMS produced had medium- (2.06 Pa·s) and high viscosity (3.59 Pa·s), with densities ranging from 0.96 to 0.99 g/mL. The refractive index was 1.4034-1.4036 and surface tension was 21 × 10
Identifiants
pubmed: 37623669
pii: jfb14080425
doi: 10.3390/jfb14080425
pmc: PMC10455291
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Kemenristek of Indonesia
ID : 1318/UN6.3.1/PT.00/2022
Organisme : Academic Leadership Grant of Universitas Padjadjaran 2022
ID : 2203/UN6.3.1/PT.00/2022
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