Investigating the Acute Metabolic Effects of the N-Methyl Carbamate Insecticide, Methomyl, on Mouse Liver.
endocrine disruptor
environmental liver disease
metabolic disrupting chemical
pesticide
toxicant-associated steatohepatitis
toxicant-associated steatotic liver disease
Journal
Metabolites
ISSN: 2218-1989
Titre abrégé: Metabolites
Pays: Switzerland
ID NLM: 101578790
Informations de publication
Date de publication:
01 Aug 2023
01 Aug 2023
Historique:
received:
21
07
2023
revised:
27
07
2023
accepted:
28
07
2023
medline:
25
8
2023
pubmed:
25
8
2023
entrez:
25
8
2023
Statut:
epublish
Résumé
Many pesticides have been identified as endocrine and metabolism-disrupting chemicals with hepatotoxic effects. However, data are limited for insecticides in the n-methyl carbamate class, including methomyl. Here, we investigate the liver and systemic metabolic effects of methomyl in a mouse model. We hypothesize that methomyl exposure will disrupt xenobiotic and intermediary metabolism and promote hepatic steatosis in mice. Male C57BL/6 mice were exposed daily to 0-5 mg/kg methomyl for 18 days. Mice were fed water and regular chow diet ad libitum. Metabolic phenotyping was performed, and tissue samples were collected. Effects were generally greatest at the highest methomyl dose, which induced
Identifiants
pubmed: 37623845
pii: metabo13080901
doi: 10.3390/metabo13080901
pmc: PMC10456691
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : NIAAA NIH HHS
ID : P50AA024337
Pays : United States
Organisme : NIDDK NIH HHS
ID : K08DK123381
Pays : United States
Organisme : NIGMS NIH HHS
ID : P20GM113226
Pays : United States
Organisme : NIEHS NIH HHS
ID : R01ES032189
Pays : United States
Organisme : NIEHS NIH HHS
ID : T32ES011564
Pays : United States
Organisme : NIEHS NIH HHS
ID : K01ES033289
Pays : United States
Organisme : NIEHS NIH HHS
ID : R35ES028373
Pays : United States
Organisme : NIEHS NIH HHS
ID : T32 ES011564
Pays : United States
Organisme : NIEHS NIH HHS
ID : P30ES030283
Pays : United States
Organisme : NIEHS NIH HHS
ID : P42ES023716
Pays : United States
Organisme : NIEHS NIH HHS
ID : T35ES014559
Pays : United States
Références
Can J Biochem Physiol. 1959 Aug;37(8):911-7
pubmed: 13671378
Environ Toxicol. 2015 Feb;30(2):212-22
pubmed: 23836410
Food Chem Toxicol. 2010 Nov;48(11):3221-6
pubmed: 20813150
Redox Biol. 2020 Apr;31:101410
pubmed: 31883838
Curr Opin Toxicol. 2019 Apr;14:21-28
pubmed: 34485777
Toxicol Res (Camb). 2018 Mar 15;7(3):480-491
pubmed: 30090598
Drug Chem Toxicol. 2022 Mar;45(2):523-536
pubmed: 32063051
Nucleic Acids Res. 2001 May 1;29(9):e45
pubmed: 11328886
J Environ Sci Health B. 2014;49(8):616-23
pubmed: 24901965
Indian J Pharmacol. 2008 Aug;40(4):158-63
pubmed: 20040949
Biochem Pharmacol. 1990 Jan 15;39(2):347-54
pubmed: 2302257
Reprod Toxicol. 2017 Mar;68:3-33
pubmed: 27760374
Virchows Arch. 1996 Aug;428(6):353-65
pubmed: 8797939
J Environ Biol. 2012 Jan;33(1):33-7
pubmed: 23033640
Toxicol Ind Health. 2015 Jan;31(1):31-43
pubmed: 23222694
Exp Toxicol Pathol. 2013 Sep;65(6):897-901
pubmed: 23375192
J Environ Sci Health A Tox Hazard Subst Environ Eng. 2012;47(12):1948-54
pubmed: 22755542
Bull Environ Contam Toxicol. 2016 Apr;96(4):423-31
pubmed: 26754544
Alcohol Clin Exp Res (Hoboken). 2023 Jan;47(1):60-75
pubmed: 36377258
J Agric Food Chem. 2018 Oct 3;66(39):10132-10138
pubmed: 30193066
Eur J Endocrinol. 1998 Mar;138(3):240-8
pubmed: 9539293
Toxicol Pathol. 2013 Feb;41(2):343-60
pubmed: 23262638
J Nutr Biochem. 2020 Oct;84:108431
pubmed: 32615368
Environ Monit Assess. 2001 Sep;70(3):233-9
pubmed: 11554484
J Am Assoc Lab Anim Sci. 2010 May;49(3):329-34
pubmed: 20587165
World J Diabetes. 2021 Nov 15;12(11):1818-1831
pubmed: 34888010