Metformin Can Attenuate Beta-Cell Hypersecretion-Implications for Treatment of Children with Obesity.
OGTT
childhood obesity
free fatty acids
glucose-stimulated insulin secretion
human islets
hyperinsulinemia
metformin
Journal
Metabolites
ISSN: 2218-1989
Titre abrégé: Metabolites
Pays: Switzerland
ID NLM: 101578790
Informations de publication
Date de publication:
04 Aug 2023
04 Aug 2023
Historique:
received:
06
07
2023
revised:
01
08
2023
accepted:
01
08
2023
medline:
25
8
2023
pubmed:
25
8
2023
entrez:
25
8
2023
Statut:
epublish
Résumé
In children with obesity, insulin hypersecretion is proposed to precede insulin resistance. We investigated if metformin could be used to attenuate insulin secretion from palmitate-treated isolated islets and its implication for children with obesity. Human islets were exposed to palmitate for 0.5 or 1 day, when metformin was introduced. After culture, glucose-stimulated insulin secretion (GSIS) was measured. Children with obesity, who had received metformin for over six months (
Identifiants
pubmed: 37623862
pii: metabo13080917
doi: 10.3390/metabo13080917
pmc: PMC10456302
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : European Commission's Seventh Framework Programme
ID : 279153
Organisme : Sweden's innovation agency
ID : 2020-02417
Organisme : EXODIAB (Swedish Research Council)
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