The combined application of bleomycin with triamcinolone acetonide in port wine stains: inhibiting proliferation and recurrence of port wine stains.
Bleomycin
Hypertrophy
Port wine stains
Recurrence
Triamcinolone acetonide
Journal
Maxillofacial plastic and reconstructive surgery
ISSN: 2288-8101
Titre abrégé: Maxillofac Plast Reconstr Surg
Pays: England
ID NLM: 101633100
Informations de publication
Date de publication:
25 Aug 2023
25 Aug 2023
Historique:
received:
26
06
2023
accepted:
10
08
2023
medline:
25
8
2023
pubmed:
25
8
2023
entrez:
25
8
2023
Statut:
epublish
Résumé
Port wine stains slowly grow thicker over time, nodules appear on the surface, and the color slowly deepens from pink to purple. Even after laser treatment, some port wine stains will recur and slowly grow, and the erythema appears again. The purpose of this study was to investigate the effectiveness of bleomycin in combination with triamcinolone acetonide in the treatment of inhibiting the proliferation and recurrence of port wine stains. Histopathological change: Before treatment, dense capillaries were distributed within the lesion, and blood fills the lumen. Lack of normal skin structure: After bleomycin and triamcinolone acetonide injection, the number of capillaries was significantly reduced, and fibrosis occurred in tissues. Changes in facial morphology: After treatment, the port wine stains became thinner, the asymmetry of the face was effectively improved, and the appearance have been significantly improved. After 5 years of follow-up, there were no recurrent cases. Bleomycin and triamcinolone acetonide injection can effectively inhibit the proliferation of port wine stains and prevent port wine stains from recurring after treatment.
Sections du résumé
BACKGROUND
BACKGROUND
Port wine stains slowly grow thicker over time, nodules appear on the surface, and the color slowly deepens from pink to purple. Even after laser treatment, some port wine stains will recur and slowly grow, and the erythema appears again. The purpose of this study was to investigate the effectiveness of bleomycin in combination with triamcinolone acetonide in the treatment of inhibiting the proliferation and recurrence of port wine stains.
RESULTS
RESULTS
Histopathological change: Before treatment, dense capillaries were distributed within the lesion, and blood fills the lumen. Lack of normal skin structure: After bleomycin and triamcinolone acetonide injection, the number of capillaries was significantly reduced, and fibrosis occurred in tissues. Changes in facial morphology: After treatment, the port wine stains became thinner, the asymmetry of the face was effectively improved, and the appearance have been significantly improved. After 5 years of follow-up, there were no recurrent cases.
CONCLUSION
CONCLUSIONS
Bleomycin and triamcinolone acetonide injection can effectively inhibit the proliferation of port wine stains and prevent port wine stains from recurring after treatment.
Identifiants
pubmed: 37624428
doi: 10.1186/s40902-023-00395-5
pii: 10.1186/s40902-023-00395-5
pmc: PMC10457260
doi:
Types de publication
Journal Article
Langues
eng
Pagination
28Informations de copyright
© 2023. Korean Association of Maxillofacial Plastic and Reconstructive Surgeons.
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