Identifying STRN3-RARA as a new fusion gene for acute promyelocytic leukemia.

Animals Mice Leukemia, Promyelocytic, Acute / drug therapy Oncogene Proteins, Fusion / genetics Tretinoin / therapeutic use

Journal

Blood
ISSN: 1528-0020
Titre abrégé: Blood
Pays: United States
ID NLM: 7603509

Informations de publication

Date de publication:
26 10 2023
Historique:
accepted: 04 08 2023
received: 27 03 2023
medline: 27 10 2023
pubmed: 25 8 2023
entrez: 25 8 2023
Statut: ppublish

Résumé

Here we report a new fusion gene, STRN3-RARA, in acute promyelocytic leukemia (APL). It cooperates with UTX deficiency to drive full-blown APL in mice. Although STRN3-RARA leukemia quickly relapses after all-trans retinoic acid treatment, it can be restrained by cepharanthine.

Identifiants

DOI: 10.1182/blood.2023020619 PMID: 37624915
pubmed: 37624915
pii: 497635
doi: 10.1182/blood.2023020619
doi:

Substances chimiques

Oncogene Proteins, Fusion 0
Tretinoin 5688UTC01R
Rara protein, mouse 0
Strn3 protein, mouse 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

1494-1499

Informations de copyright

© 2023 by The American Society of Hematology.

Auteurs

Qi Zhang (Q)

Department of Hematology and Institute of Hematology, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan, China.

He Li (H)

Department of Hematology, Institute of Hematology, West China Hospital, Sichuan University, Chengdu, Sichuan, China.

Xuelan Chen (X)

Department of Hematology and Institute of Hematology, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
ORCID: 0000-0003-3987-4971

Fan Gu (F)

Department of Hematology and Institute of Hematology, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan, China.

Lanxin Zhang (L)

Department of Hematology and Institute of Hematology, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan, China.

Lu Zhang (L)

Department of Hematology and Institute of Hematology, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
ORCID: 0000-0001-9337-093X

Tong Chen (T)

Sichuan Hua Xi Kindstar Medical Diagnostic Centre, Chengdu, Sichuan, China.

Qiang Chen (Q)

Sichuan Neo-Life Stem Cell Biotech Inc, Institute of Blood Transfusion, Chinese Academy of Medical Sciences and Peking Union Medical College, Chengdu, Sichuan, China.

Wentong Meng (W)

Laboratory of Stem Cell Biology, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, China.
ORCID: 0000-0002-9592-5668

Yu Wu (Y)

Department of Hematology, Institute of Hematology, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
ORCID: 0000-0001-8708-9711

Hong Chang (H)

Department of Hematology, Institute of Hematology, West China Hospital, Sichuan University, Chengdu, Sichuan, China.

Ting Liu (T)

Department of Hematology, Institute of Hematology, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
ORCID: 0000-0003-1816-5551

Chong Chen (C)

Department of Hematology and Institute of Hematology, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan, China.

Hongbing Ma (H)

Department of Hematology, Institute of Hematology, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
ORCID: 0000-0002-1174-4078

Yu Liu (Y)

Department of Hematology and Institute of Hematology, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
ORCID: 0000-0002-1193-7830

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Identifying STRN3-RARA as a new fusion gene...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Identifying STRN3-RARA as a new fusion gene...
questionsmedicales.fr › Tumeurs › Tumeurs par type histologique › Leucémies › Leucémie myéloïde › Leucémie aigüe myéloïde › Leucémie aiguë promyélocytaire › Identifying STRN3-RARA as a new fusion gene...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines tumorales › Protéines oncogènes › Protéines de fusion oncogènes › Identifying STRN3-RARA as a new fusion gene...
questionsmedicales.fr › Facteurs biologiques › Pigments biologiques › Caroténoïdes › Rétinoïdes › Trétinoïne › Identifying STRN3-RARA as a new fusion gene...