Persistent modulatory actions and task switching in the feeding network of Aplysia.


Journal

Current opinion in neurobiology
ISSN: 1873-6882
Titre abrégé: Curr Opin Neurobiol
Pays: England
ID NLM: 9111376

Informations de publication

Date de publication:
10 2023
Historique:
received: 18 06 2023
revised: 26 07 2023
accepted: 01 08 2023
pmc-release: 01 10 2024
medline: 11 9 2023
pubmed: 26 8 2023
entrez: 25 8 2023
Statut: ppublish

Résumé

The activity of multifunctional networks is configured by neuromodulators that exert persistent effects. This raises a question, does this impact the ability of a network to switch from one type of activity to another? We review studies that have addressed this question in the Aplysia feeding circuit. Task switching in this system occurs "asymmetrically." When there is a switch from egestion to ingestion neuromodulation impedes switching (creates a "negative bias"). When there is a switch from ingestion to egestion the biasing is "positive." Ingestion promotes subsequent egestion. We contrast mechanisms responsible for the two types of biasing and show that the observed asymmetry is a consequence of the fact that there is more than one set of egestive circuit parameters.

Identifiants

pubmed: 37625344
pii: S0959-4388(23)00100-9
doi: 10.1016/j.conb.2023.102775
pmc: PMC10530010
mid: NIHMS1922952
pii:
doi:

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

102775

Subventions

Organisme : NINDS NIH HHS
ID : R01 NS066587
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS070583
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS118606
Pays : United States
Organisme : NINDS NIH HHS
ID : RF1 NS118606
Pays : United States

Informations de copyright

Copyright © 2023 Elsevier Ltd. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of competing interest There are no declarations of interest for any of the authors.

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Auteurs

Elizabeth C Cropper (EC)

Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY 10029, USA. Electronic address: Elizabeth.cropper@gmail.com.

Matthew Perkins (M)

Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY 10029, USA.

Jian Jing (J)

Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY 10029, USA; State Key Laboratory of Pharmaceutical Biotechnology, Institute for Brain Sciences, Chemistry and Biomedicine Innovation Center, Jiangsu Engineering Research Center for MicroRNA Biology and Biotechnology, Advanced Institute for Life Sciences, School of Life Sciences, Nanjing University, Nanjing, Jiangsu, China.

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Classifications MeSH