Potential of bone morphogenetic protein-7 in treatment of lupus nephritis: addressing the hurdles to implementation.
Africa
Fibrosis
Systemic lupus erythematosus
TGF-beta
Tubulo-interstitial inflammation
Journal
Inflammopharmacology
ISSN: 1568-5608
Titre abrégé: Inflammopharmacology
Pays: Switzerland
ID NLM: 9112626
Informations de publication
Date de publication:
Oct 2023
Oct 2023
Historique:
received:
03
08
2023
accepted:
15
08
2023
medline:
23
10
2023
pubmed:
26
8
2023
entrez:
25
8
2023
Statut:
ppublish
Résumé
Up to 50% of systemic lupus erythematosus (SLE) patients world-wide develop lupus nephritis (LN). In low to middle income countries and in particular in sub-Saharan Africa, where SLE is prevalent with a more aggressive course, LN and end stage renal disease is a major cause of mortality. While developed countries have the funding to invest in SLE and LN research, patients of African descent are often underrepresented in clinical trials. Thus, the complex influence of ethnicity and genetic background on outcome of LN and SLE as a whole, is not fully understood. Several pathophysiological mechanisms including major role players driving LN have been identified. A large body of literature suggest that prevention of fibrosis-which contributes to chronicity of LN-may significantly improve long-term prognosis. Bone morphogenetic protein-7 (BMP-7) was first identified as a therapeutic option in this context decades ago and evidence of its benefit in various conditions, including LN, is ever-increasing. Despite these facts, BMP-7 is not being implemented as therapy in the context of renal disease. With this review, we briefly summarise current understanding of LN pathology and discuss the evidence in support of therapeutic potential of BMP-7 in this context. Lastly, we address the obstacles that need to be overcome, before BMP-7 may become available as LN treatment.
Identifiants
pubmed: 37626268
doi: 10.1007/s10787-023-01321-x
pii: 10.1007/s10787-023-01321-x
pmc: PMC10518293
doi:
Substances chimiques
Bone Morphogenetic Protein 7
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
2161-2172Subventions
Organisme : National Research Foundation
ID : TO2022/3
Informations de copyright
© 2023. The Author(s).
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