Metabolomics Analysis of DRG and Serum in the CCI Model of Mice.
DRG
metabolomics
neuropathic pain
serum
Journal
Brain sciences
ISSN: 2076-3425
Titre abrégé: Brain Sci
Pays: Switzerland
ID NLM: 101598646
Informations de publication
Date de publication:
21 Aug 2023
21 Aug 2023
Historique:
received:
15
07
2023
revised:
08
08
2023
accepted:
15
08
2023
medline:
26
8
2023
pubmed:
26
8
2023
entrez:
26
8
2023
Statut:
epublish
Résumé
Neuropathic pain (NP) is a chronic and intractable disease that is widely present in the general population. It causes painful behavior and even mood changes such as anxiety and depression by altering the metabolism of substances. However, there have been limited metabolomics studies conducted in relation to neuropathic pain. Therefore, in this study, the effects of NP on metabolites in serum and the dorsal root ganglion (DRG) were investigated using a non-targeted metabolomics approach detected by gas chromatography-mass spectrometry (GC-MS) and liquid chromatography-mass spectrometry (LC-MS) to uncover differential metabolites and affected metabolic pathways associated with NP. Sixty mice were divided into the following two groups: a chronic constriction injury (CCI) of the sciatic nerve group and a sham group (
Identifiants
pubmed: 37626580
pii: brainsci13081224
doi: 10.3390/brainsci13081224
pmc: PMC10452726
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : National Natural Science Foundation of China
ID : 82001178, 81901129, 82001175
Organisme : Shanghai Sailing Program
ID : 20YF1439200
Organisme : Natural Science Foundation of Shanghai, China
ID : No.23ZR1450800
Références
Lancet Neurol. 2010 Aug;9(8):807-19
pubmed: 20650402
World J Diabetes. 2015 Apr 15;6(3):432-44
pubmed: 25897354
Rheumatology (Oxford). 2008 Aug;47(8):1235-8
pubmed: 18550637
Pain. 2014 Apr;155(4):654-662
pubmed: 24291734
Int J Environ Res Public Health. 2022 May 30;19(11):
pubmed: 35682282
Analyst. 2012 Jan 21;137(2):293-300
pubmed: 22102985
Sci Rep. 2022 Oct 11;12(1):17012
pubmed: 36220867
Cells. 2020 Mar 27;9(4):
pubmed: 32230947
J Phys Chem B. 2021 Jun 17;125(23):6201-6213
pubmed: 34081470
Sci Adv. 2021 Oct 22;7(43):eabd5046
pubmed: 34678069
J Neurotrauma. 2013 Jun 1;30(11):897-906
pubmed: 23363551
J Lipid Res. 2012 Feb;53(2):300-10
pubmed: 22158827
Mol Aspects Med. 2011 Aug;32(4-6):223-33
pubmed: 22020112
Metabolomics. 2020 May 18;16(6):66
pubmed: 32419109
Pain. 2011 Oct;152(10):2204-2205
pubmed: 21764514
Apoptosis. 2006 Sep;11(9):1573-82
pubmed: 16703260
Biochim Biophys Acta Biomembr. 2017 Sep;1859(9 Pt B):1629-1635
pubmed: 28495596
PLoS One. 2011;6(10):e26107
pubmed: 22046257
J Neurochem. 2004 Mar;88(5):1041-51
pubmed: 15009660
J Neuroimmune Pharmacol. 2013 Jun;8(3):576-93
pubmed: 23666436
Pain. 2019 Jan;160(1):53-59
pubmed: 30586071
BMC Neurosci. 2004 Apr 20;5:15
pubmed: 15099403
Medicina (Kaunas). 2023 Jan 29;59(2):
pubmed: 36837458
Clin Rheumatol. 2022 Sep;41(9):2647-2658
pubmed: 35643813
J Neurosci Methods. 1994 Jul;53(1):55-63
pubmed: 7990513
J Genet Genomics. 2020 Feb 20;47(2):69-83
pubmed: 32178981
Mol Pain. 2014 Sep 25;10:63
pubmed: 25253440
Exp Neurol. 2014 Jan;251:12-21
pubmed: 24212047
Biol Res. 2021 Aug 6;54(1):24
pubmed: 34362470
Prog Neurobiol. 2007 Feb;81(2):89-131
pubmed: 17275978
Trends Pharmacol Sci. 2005 Sep;26(9):477-84
pubmed: 16055199
Mol Cell. 2012 Oct 26;48(2):242-53
pubmed: 22959274
Neurosci Lett. 2020 Jul 13;731:135029
pubmed: 32380144
Neurosci Lett. 2009 Oct 23;464(2):93-7
pubmed: 19699266
Neurochem Res. 1999 Feb;24(2):249-54
pubmed: 9972871
Oxid Med Cell Longev. 2022 Sep 1;2022:4722647
pubmed: 36092157
J Cell Biol. 2011 Jan 10;192(1):7-16
pubmed: 21220505
J Neurochem. 2011 Aug;118(4):490-8
pubmed: 21644997
Nutrients. 2023 Jan 31;15(3):
pubmed: 36771421
Glia. 2022 Mar;70(3):397-413
pubmed: 34549463
J Neuroimaging. 2017 Nov;27(6):562-569
pubmed: 28736910
Cell Res. 2021 Aug;31(8):904-918
pubmed: 33692491
J Neurotrauma. 2015 Jul 15;32(14):1056-63
pubmed: 25333480
Nat Rev Neurol. 2010 May;6(5):276-87
pubmed: 20404842
Biochimie. 2022 Dec;203:20-31
pubmed: 36055603
Neurochem Res. 2013 Dec;38(12):2535-41
pubmed: 24104610