The Value of White Cell Inflammatory Biomarkers as Potential Predictors for Diabetic Retinopathy in Type 2 Diabetes Mellitus (T2DM).
biomarkers
diabetic retinopathy
monocyte-to-lymphocyte ratio (MLR)
neutrophil-to-lymphocyte ratio (NLR)
platelet-to-lymphocyte ratio (PLR)
systemic inflammation index (SII)
Journal
Biomedicines
ISSN: 2227-9059
Titre abrégé: Biomedicines
Pays: Switzerland
ID NLM: 101691304
Informations de publication
Date de publication:
26 Jul 2023
26 Jul 2023
Historique:
received:
03
07
2023
revised:
19
07
2023
accepted:
24
07
2023
medline:
26
8
2023
pubmed:
26
8
2023
entrez:
26
8
2023
Statut:
epublish
Résumé
The pathogenesis of diabetic retinopathy is still challenging, with recent evidence proving the key role of inflammation in the damage of the retinal neurovascular unit. This study aims to investigate the predictive value of the neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte (PLR), lymphocyte-to-monocyte ratio (LMR), and systemic inflammation index (SII) for diabetic retinopathy (DR) and its severity. We performed a retrospective study on 129 T2DM patients, divided into three groups: without retinopathy (NDR), non-proliferative DR (NPDR), and proliferative DR (PDR). NLR, MLR, and SII were significantly higher in the PDR group when compared to NDR and NPDR (3.2 ± 1.6 vs. 2.4 ± 0.9 and 2.4 ± 1.1;
Identifiants
pubmed: 37626602
pii: biomedicines11082106
doi: 10.3390/biomedicines11082106
pmc: PMC10452280
pii:
doi:
Types de publication
Journal Article
Langues
eng
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