Effect of Kinins on the Hepatic Oxidative Stress in Mice Treated with a Methionine-Choline Deficient Diet.
NASH
liver
methionine-choline deficient diet
oxidative stress
steatosis
Journal
Biomedicines
ISSN: 2227-9059
Titre abrégé: Biomedicines
Pays: Switzerland
ID NLM: 101691304
Informations de publication
Date de publication:
04 Aug 2023
04 Aug 2023
Historique:
received:
30
06
2023
revised:
21
07
2023
accepted:
26
07
2023
medline:
26
8
2023
pubmed:
26
8
2023
entrez:
26
8
2023
Statut:
epublish
Résumé
Non-alcoholic fatty liver is the leading cause of hepatic disease worldwide and ranges from simple steatosis to non-alcoholic steatohepatitis (NASH) due to cell injury, oxidative stress, and apoptosis. The kinins' role in the liver has been studied in experimental fibrosis, partial hepatectomy, and ischemia-reperfusion and is related to cell death and regeneration. We investigated its role in experimental NASH induced by a methionine-choline deficient diet for 4 weeks. After that, liver perfusion was performed, and bradykinin (BK) or des-Arg
Identifiants
pubmed: 37626696
pii: biomedicines11082199
doi: 10.3390/biomedicines11082199
pmc: PMC10452290
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : São Paulo Research Foundation
ID : 2017/00896-5
Organisme : Coordenação de Aperfeicoamento de Pessoal de Nível Superior
ID : 88887.500746/2020-0
Organisme : National Council for Scientific and Technological Development
ID : DAR productivity fellowship
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