The Role of Mesenchymal Stem Cell Secretome in the Inflammatory Mediators and the Survival Rate of Rat Model of Sepsis.
IL-10
NF-κB
TNF-α
secretome
sepsis
survival rate
Journal
Biomedicines
ISSN: 2227-9059
Titre abrégé: Biomedicines
Pays: Switzerland
ID NLM: 101691304
Informations de publication
Date de publication:
21 Aug 2023
21 Aug 2023
Historique:
received:
07
08
2023
accepted:
11
08
2023
medline:
26
8
2023
pubmed:
26
8
2023
entrez:
26
8
2023
Statut:
epublish
Résumé
In sepsis, simultaneously elevated levels of pro-inflammatory cytokines and interleukin (IL)-10 indicate immune response dysregulation, increasing the mortality of the host. As mesenchymal stem cell (MSC) secretome is known to have immunomodulatory effects, we aim to assess the role of MSC secretome in the inflammatory mediators (NF-κB p65 and p50, TNF-α, IL-10) and the survival rate of a rat model of sepsis. In this study, forty-eight male
Identifiants
pubmed: 37626822
pii: biomedicines11082325
doi: 10.3390/biomedicines11082325
pmc: PMC10452511
pii:
doi:
Types de publication
Journal Article
Langues
eng
Références
Int J Infect Dis. 2021 Feb;103:343-351
pubmed: 33221519
Oncotarget. 2016 Aug 9;7(32):52294-52306
pubmed: 27418133
Stem Cell Res Ther. 2019 Nov 26;10(1):345
pubmed: 31771622
Med Sci Monit. 2020 Jan 29;26:e919054
pubmed: 31992687
Oncogene. 2013 Mar 21;32(12):1549-59
pubmed: 22641218
Mil Med Res. 2022 Oct 9;9(1):56
pubmed: 36209190
MedComm (2020). 2021 Dec 16;2(4):618-653
pubmed: 34977871
Front Immunol. 2019 Apr 09;10:705
pubmed: 31024544
Int J Mol Sci. 2017 Aug 25;18(9):
pubmed: 28841158
J Autoimmun. 2017 Dec;85:20-31
pubmed: 28676205
Int J Mol Sci. 2023 May 31;24(11):
pubmed: 37298529
Pharmaceutics. 2021 Oct 27;13(11):
pubmed: 34834217
Stem Cell Res Ther. 2021 Jan 7;12(1):14
pubmed: 33413595
Exp Ther Med. 2018 Aug;16(2):842-846
pubmed: 30112039
Mucosal Immunol. 2022 Jun;15(6):1257-1269
pubmed: 35428872
Front Med (Lausanne). 2022 May 12;9:765805
pubmed: 35646946
Eur J Pharmacol. 2020 Jun 15;877:173090
pubmed: 32234529
N Engl J Med. 2014 Nov 6;371(19):1761-3
pubmed: 25271470
Oncotarget. 2017 Dec 14;9(6):7204-7218
pubmed: 29467962
BMC Res Notes. 2014 Apr 12;7:233
pubmed: 24725742
Cell Mol Biol Lett. 2019 Dec 03;24:64
pubmed: 31827540
Front Immunol. 2013 May 31;4:129
pubmed: 23755052
World J Stem Cells. 2014 Nov 26;6(5):552-70
pubmed: 25426252
PLoS One. 2017 Jan 10;12(1):e0169653
pubmed: 28072859
Sci Rep. 2018 Sep 18;8(1):13995
pubmed: 30228372
Front Cell Infect Microbiol. 2017 Nov 21;7:483
pubmed: 29209595
N Engl J Med. 2020 Dec 3;383(23):2255-2273
pubmed: 33264547
Crit Care Med. 2014 Aug;42(8):1749-55
pubmed: 24717459
Cold Spring Harb Perspect Biol. 2017 Jan 3;9(1):
pubmed: 27836834
Mol Biol (Mosk). 2019 Sep-Oct;53(5):799-814
pubmed: 31661479
Mediators Inflamm. 2013;2013:165974
pubmed: 23853427
Front Immunol. 2022 Jan 05;12:810286
pubmed: 35069596
Expert Opin Investig Drugs. 2018 Apr;27(4):325-338
pubmed: 29611447
F1000Res. 2021 Mar 22;10:228
pubmed: 35350705
Antimicrob Resist Infect Control. 2020 Jan 30;9(1):21
pubmed: 32000850
N Engl J Med. 2013 Aug 29;369(9):840-51
pubmed: 23984731
Curr Issues Mol Biol. 2022 Apr 12;44(4):1701-1712
pubmed: 35723375
Acta Neuropathol. 2016 Nov;132(5):685-701
pubmed: 27497943
Front Immunol. 2021 Feb 25;12:622601
pubmed: 33717127
Am J Transl Res. 2017 Mar 15;9(3):1521-1529
pubmed: 28386377
Int J Mol Sci. 2023 Jan 13;24(2):
pubmed: 36675101
Front Immunol. 2019 Feb 04;10:85
pubmed: 30778349
Artif Cells Nanomed Biotechnol. 2018;46(sup2):1178-1187
pubmed: 29929400
Shock. 2019 Mar;51(3):356-363
pubmed: 29608550
Med Glas (Zenica). 2020 Aug 1;17(2):408-413
pubmed: 32602296
Int J Mol Sci. 2021 Mar 08;22(5):
pubmed: 33800290
Front Immunol. 2021 Jun 21;12:677008
pubmed: 34234779
Lancet. 2020 Feb 15;395(10223):497-506
pubmed: 31986264
Lancet. 2020 Jan 18;395(10219):200-211
pubmed: 31954465
Malays J Med Sci. 2017 Oct;24(5):101-105
pubmed: 29386977
Front Cell Dev Biol. 2019 Jun 20;7:108
pubmed: 31281814
J Immunol. 2018 Mar 1;200(5):1543-1553
pubmed: 29463691
In Vivo. 2013 Nov-Dec;27(6):669-84
pubmed: 24292568
J Environ Sci (China). 2010;22(6):846-50
pubmed: 20923095
Biochim Biophys Acta Mol Basis Dis. 2018 Jan;1864(1):178-188
pubmed: 28993190
Crit Care. 2019 Nov 28;23(1):384
pubmed: 31779663
Int Immunopharmacol. 2022 Mar;104:108469
pubmed: 35008005
J Pharmacol Pharmacother. 2013 Oct;4(4):303-6
pubmed: 24250214
Surg Infect (Larchmt). 2016 Aug;17(4):385-93
pubmed: 27305321
Biomed Res Int. 2022 Jan 27;2022:5700853
pubmed: 35127944
Signal Transduct Target Ther. 2017;2:
pubmed: 29158945
Front Pharmacol. 2020 Jul 29;11:1036
pubmed: 32848725
J Med Food. 2014 Oct;17(10):1095-102
pubmed: 25238321
Am J Respir Crit Care Med. 2016 Feb 1;193(3):259-72
pubmed: 26414292
Braz J Infect Dis. 2020 Nov - Dec;24(6):552-560
pubmed: 33169675
Exp Ther Med. 2018 Jul;16(1):291-299
pubmed: 29896252
SAGE Open Med. 2019 Mar 21;7:2050312119835043
pubmed: 30915218
Signal Transduct Target Ther. 2022 Mar 21;7(1):92
pubmed: 35314676
BMC Infect Dis. 2020 Mar 14;20(1):221
pubmed: 32171247