Peptidylarginine Deiminase Type 2 Predicts Tumor Progression and Poor Prognosis in Patients with Curatively Resected Biliary Tract Cancer.
biliary tract cancer
peptidylarginine deiminase type 2
prognosis
survival
Journal
Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829
Informations de publication
Date de publication:
16 Aug 2023
16 Aug 2023
Historique:
received:
30
05
2023
revised:
14
08
2023
accepted:
15
08
2023
medline:
26
8
2023
pubmed:
26
8
2023
entrez:
26
8
2023
Statut:
epublish
Résumé
(1) Background: PADI2 is a post-translational modification (PTM) enzyme that catalyzes citrullination, which then triggers autoimmune disease and cancer. This study aimed to evaluate the prognostic value of peptidylarginine deiminase 2 (PADI2) protein expression in biliary tract cancer (BTC) patients. (2) Methods: Using immunohistochemistry, the PADI2 protein expression in BTC tissues was analyzed. The correlations between PADI2 protein expression and clinicopathologic characteristics were analyzed using Chi-square tests. The Kaplan-Meier procedure was used for comparing survival distributions. We used Cox proportional hazards regression for univariate and multivariate analyses. From 2014 to 2020, 30 resected BTC patients were enrolled in this study. (3) Results: Patients with high PADI2 protein expression were associated with shorter progress-free survival (PFS;
Identifiants
pubmed: 37627159
pii: cancers15164131
doi: 10.3390/cancers15164131
pmc: PMC10452823
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Buddhist Tzu Chi Medical Foundation
ID : DTCRD110(2)-I-08, DTCRD111(2)-I-02, DTCRD111-I-08
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