Chronic Hepatitis B Infection: New Approaches towards Cure.
antivirals
chronic hepatitis B
gene editing
hepatitis B virus
Journal
Biomolecules
ISSN: 2218-273X
Titre abrégé: Biomolecules
Pays: Switzerland
ID NLM: 101596414
Informations de publication
Date de publication:
01 08 2023
01 08 2023
Historique:
received:
07
06
2023
revised:
24
07
2023
accepted:
28
07
2023
medline:
28
8
2023
pubmed:
26
8
2023
entrez:
26
8
2023
Statut:
epublish
Résumé
Chronic hepatitis B virus (HBV) infection leads to the development of cirrhosis and hepatocellular carcinoma. Lifelong treatment with nucleotides/nucleoside antiviral agents is effective at suppressing HBV replication, however, adherence to daily therapy can be challenging. This review discusses recent advances in the development of long-acting formulations for HBV treatment and prevention, which could potentially improve adherence. Promising new compounds that target distinct steps of the virus life cycle are summarized. In addition to treatments that suppress viral replication, curative strategies are focused on the elimination of covalently closed circular DNA and the inactivation of the integrated viral DNA from infected hepatocytes. We highlight promising long-acting antivirals and genome editing strategies for the elimination or deactivation of persistent viral DNA products in development.
Identifiants
pubmed: 37627273
pii: biom13081208
doi: 10.3390/biom13081208
pmc: PMC10452112
pii:
doi:
Substances chimiques
DNA, Viral
0
Antiviral Agents
0
Types de publication
Journal Article
Review
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIAAA NIH HHS
ID : R01 AA027189
Pays : United States
Organisme : NIAAA NIH HHS
ID : P50 AA030407
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK135817
Pays : United States
Organisme : NIAAA NIH HHS
ID : K01 AA026864
Pays : United States
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