Circulating H3K27 Methylated Nucleosome Plasma Concentration: Synergistic Information with Circulating Tumor DNA Molecular Profiling.
H3K27Me3 nucleosome
MRD
NSCLC
biomarkers
ctDNA
epigenetics
histone PTM
liquid biopsy
Journal
Biomolecules
ISSN: 2218-273X
Titre abrégé: Biomolecules
Pays: Switzerland
ID NLM: 101596414
Informations de publication
Date de publication:
16 08 2023
16 08 2023
Historique:
received:
05
07
2023
revised:
04
08
2023
accepted:
07
08
2023
medline:
28
8
2023
pubmed:
26
8
2023
entrez:
26
8
2023
Statut:
epublish
Résumé
The molecular profiling of circulating tumor DNA (ctDNA) is a helpful tool not only in cancer treatment, but also in the early detection of relapse. However, the clinical interpretation of a ctDNA negative result remains challenging. The characterization of circulating nucleosomes (carrying cell-free DNA) and associated epigenetic modifications (playing a key role in the tumorigenesis of different cancers) may provide useful information for patient management, by supporting the contributive value of ctDNA molecular profiling. Significantly elevated concentrations of H3K27Me3 nucleosomes were found in plasmas at the diagnosis, and during the follow-up, of NSCLC patients, compared to healthy donors (
Identifiants
pubmed: 37627320
pii: biom13081255
doi: 10.3390/biom13081255
pmc: PMC10452235
pii:
doi:
Substances chimiques
Nucleosomes
0
Circulating Tumor DNA
0
Histones
0
Cell-Free Nucleic Acids
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Références
ACS Sens. 2021 Dec 24;6(12):4369-4378
pubmed: 34878766
JCO Clin Cancer Inform. 2021 Oct;5:1085-1095
pubmed: 34731027
Cancers (Basel). 2023 Mar 21;15(6):
pubmed: 36980762
Clin Cancer Res. 2004 Sep 15;10(18 Pt 1):5981-7
pubmed: 15447981
Cancer Discov. 2019 Jul;9(7):837-851
pubmed: 30992279
Nature. 2002 Oct 10;419(6907):624-9
pubmed: 12374981
Clin Cancer Res. 2019 Aug 1;25(15):4691-4700
pubmed: 30988079
Sci Rep. 2021 May 24;11(1):10761
pubmed: 34031447
Curr Opin Genet Dev. 2017 Apr;43:31-37
pubmed: 27940208
Cancer Res. 2020 Oct 1;80(19):4037-4041
pubmed: 32554552
Lung Cancer. 2019 Jun;132:65-71
pubmed: 31097096
Front Oncol. 2020 Dec 10;10:610923
pubmed: 33363040
JCI Insight. 2021 Apr 8;6(7):
pubmed: 33571170
Cancer Discov. 2017 Dec;7(12):1394-1403
pubmed: 28899864
Clin Epigenetics. 2021 May 17;13(1):115
pubmed: 34001289
Nat Rev Genet. 2012 Apr 03;13(5):343-57
pubmed: 22473383
Genome Biol. 2019 Nov 20;20(1):245
pubmed: 31747960
Nat Genet. 2019 Mar;51(3):517-528
pubmed: 30692681
Mol Diagn Ther. 2021 Mar;25(2):239-250
pubmed: 33660188
Nat Rev Cancer. 2011 Jun;11(6):426-37
pubmed: 21562580
Proc Natl Acad Sci U S A. 2003 Sep 30;100(20):11606-11
pubmed: 14500907
Cancers (Basel). 2022 Jul 04;14(13):
pubmed: 35805046
Endocr Pathol. 2019 Dec;30(4):305-311
pubmed: 31396854
Clin Epigenetics. 2020 Feb 10;12(1):24
pubmed: 32041674
Am Soc Clin Oncol Educ Book. 2019 Jan;39:531-542
pubmed: 31099633
Cancer Cell. 2010 Aug 9;18(2):185-97
pubmed: 20708159
J Hematol Oncol. 2020 Jul 28;13(1):104
pubmed: 32723346
Front Oncol. 2021 Feb 15;10:595650
pubmed: 33659207
Clin Cancer Res. 2000 Oct;6(10):4055-63
pubmed: 11051256
Int J Mol Sci. 2023 Jan 04;24(2):
pubmed: 36674455
Proc Natl Acad Sci U S A. 2008 Oct 21;105(42):16266-71
pubmed: 18838674
Ann N Y Acad Sci. 2008 Aug;1137:180-9
pubmed: 18837945
Mol Ther Nucleic Acids. 2019 Jun 7;16:155-161
pubmed: 30889481
Nat Cancer. 2021 Apr;2(4):377-391
pubmed: 35122001
Lancet. 2016 Apr 2;387(10026):1415-1426
pubmed: 26777916
Ann N Y Acad Sci. 2006 Sep;1075:191-6
pubmed: 17108211
Biomol Detect Quantif. 2019 Mar 18;17:100087
pubmed: 30923679
Ann Oncol. 2022 May;33(5):500-510
pubmed: 35306155
Lung Cancer. 2022 Jan 20;165:34-42
pubmed: 35085982
Clin Transl Oncol. 2013 Feb;15(2):132-8
pubmed: 22855181
Mol Cancer. 2021 Jun 1;20(1):82
pubmed: 34074295
Nat Rev Cancer. 2016 Dec;16(12):803-810
pubmed: 27658528
Cancers (Basel). 2017 Jan 08;9(1):
pubmed: 28075351
BMC Cancer. 2020 Dec 4;20(1):1189
pubmed: 33276757
Mol Cells. 2018 Sep 30;41(9):868-880
pubmed: 30304920
Nat Rev Cancer. 2013 May;13(5):365-76
pubmed: 23535846
Cancers (Basel). 2020 Dec 05;12(12):
pubmed: 33291363
Sci Rep. 2013;3:1911
pubmed: 23714854
Lung Cancer. 2019 Aug;134:79-84
pubmed: 31320000
Oncotarget. 2017 Sep 21;8(50):87980-87996
pubmed: 29152135
Int J Mol Sci. 2020 Oct 29;21(21):
pubmed: 33137955
Mol Med. 2011;17(11-12):1137-45
pubmed: 21738951
Oncotarget. 2016 Dec 20;7(51):84453-84467
pubmed: 27563817
Cancer. 2020 Jul 15;126(14):3219-3228
pubmed: 32365229
Cancer Metastasis Rev. 2016 Sep;35(3):347-76
pubmed: 27392603
Mol Clin Oncol. 2016 Dec;5(6):705-713
pubmed: 28101350
Epigenetics Chromatin. 2018 Mar 16;11(1):11
pubmed: 29548294