COVID-19 and Male Infertility: Is There a Role for Antioxidants?
COVID-19
SARS-CoV-2
antioxidants
male infertility
oxidative stress
reactive oxygen species
Journal
Antioxidants (Basel, Switzerland)
ISSN: 2076-3921
Titre abrégé: Antioxidants (Basel)
Pays: Switzerland
ID NLM: 101668981
Informations de publication
Date de publication:
25 Jul 2023
25 Jul 2023
Historique:
received:
12
06
2023
revised:
14
07
2023
accepted:
22
07
2023
medline:
26
8
2023
pubmed:
26
8
2023
entrez:
26
8
2023
Statut:
epublish
Résumé
Coronavirus disease 19 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), jeopardizes male fertility because of the vulnerability of the male reproductive system, especially the testes. This study evaluates the effects of the virus on testicular function and examines the potential role of antioxidants in mitigating the damage caused by oxidative stress (OS). A comprehensive PubMed search examined exocrine and endocrine testicular function alteration, the interplay between OS and COVID-19-induced defects, and the potential benefit of antioxidants. Although the virus is rarely directly detectable in sperm and testicular tissue, semen quality and hormonal balance are affected in patients, with some changes persisting throughout a spermatogenesis cycle. Testicular pathology in deceased patients shows defects in spermatogenesis, vascular changes, and inflammation. Acute primary hypogonadism is observed mainly in severely infected cases. Elevated OS and sperm DNA fragmentation markers suggest redox imbalance as a possible mechanism behind the fertility changes. COVID-19 vaccines appear to be safe for male fertility, but the efficacy of antioxidants to improve sperm quality after infection remains unproven due to limited research. Given the limited and inconclusive evidence, careful evaluation of men recovering from COVID-19 seeking fertility improvement is strongly recommended.
Identifiants
pubmed: 37627478
pii: antiox12081483
doi: 10.3390/antiox12081483
pmc: PMC10451649
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Références
J Cell Mol Med. 2020 Aug;24(16):9472-9477
pubmed: 32594644
Am J Clin Pathol. 2020 May 5;153(6):725-733
pubmed: 32275742
Fertil Steril. 2005 Sep;84(3):662-71
pubmed: 16169400
Science. 2020 Mar 13;367(6483):1260-1263
pubmed: 32075877
Biomedicines. 2022 Nov 28;10(12):
pubmed: 36551814
J Assist Reprod Genet. 2022 Oct;39(10):2249-2254
pubmed: 36114906
Eur Rev Med Pharmacol Sci. 2022 May;26(10):3745-3750
pubmed: 35647857
Antioxidants (Basel). 2022 Mar 14;11(3):
pubmed: 35326201
Reprod Fertil. 2022 Sep 1;:
pubmed: 36065800
Andrologia. 2022 Mar;54(2):e14281
pubmed: 34672002
Prog Urol. 2022 Dec;32(16):1431-1439
pubmed: 36153222
Cancer Res. 1999 Sep 1;59(17):4180-4
pubmed: 10485450
Curr Pharm Des. 2021;27(23):2665-2668
pubmed: 32124691
Cell Mol Immunol. 2021 Feb;18(2):487-489
pubmed: 33318629
Arch Pathol Lab Med. 2021 Jan 1;145(1):8-9
pubmed: 33367666
Andrologia. 2021 Sep;53(8):e14145
pubmed: 34115405
Arab J Urol. 2018 Feb 01;16(1):87-95
pubmed: 29713539
Andrologia. 2021 Oct;53(9):e14157
pubmed: 34268784
Asian J Androl. 2022 Sep-Oct;24(5):441-444
pubmed: 35532560
Front Reprod Health. 2022 Feb 03;4:782915
pubmed: 36303638
Clin Exp Reprod Med. 2021 Jun;48(2):150-155
pubmed: 34078008
Reproduction. 2021 Mar;161(3):319-331
pubmed: 33522983
Health Sci Rep. 2022 Dec 24;6(1):e1011
pubmed: 36582631
Reprod Fertil Dev. 2021 Oct;33(12):683-690
pubmed: 34324827
QJM. 2021 Aug 29;114(5):328-330
pubmed: 33508136
Int J Mol Sci. 2022 Sep 02;23(17):
pubmed: 36077455
Cells. 2020 Apr 09;9(4):
pubmed: 32283711
Transl Androl Urol. 2020 Oct;9(5):1897-1900
pubmed: 33209652
Andrologia. 2021 Sep;53(8):e14136
pubmed: 34115901
Emerg Microbes Infect. 2020 Dec;9(1):469-473
pubmed: 32102625
Nature. 2020 Sep;585(7825):342-343
pubmed: 32934351
Andrology. 2022 Sep;10(6):1023-1029
pubmed: 35647664
N Engl J Med. 2020 Apr 30;382(18):1708-1720
pubmed: 32109013
Int J Impot Res. 2020 Sep;32(5):560-562
pubmed: 32796934
Eur Urol Focus. 2020 Sep 15;6(5):1124-1129
pubmed: 32563676
World J Mens Health. 2022 Oct;40(4):570-579
pubmed: 36047069
Int Braz J Urol. 2022 Jan-Feb;48(1):131-156
pubmed: 34472769
Reprod Sci. 2022 Jan;29(1):1-6
pubmed: 33415646
BJU Int. 2022 Jun;130 Suppl 1:20-21
pubmed: 35182404
J Hypertens. 2022 Sep 1;40(9):1629-1638
pubmed: 35943095
Arch Ital Urol Androl. 2021 Dec 21;93(4):465-467
pubmed: 34933532
Cell. 2020 Apr 16;181(2):281-292.e6
pubmed: 32155444
Andrologia. 2022 Dec;54(11):e14574
pubmed: 36038521
Arch Med Res. 2020 Jul;51(5):384-387
pubmed: 32402576
Front Physiol. 2020 Nov 17;11:574761
pubmed: 33312128
Andrology. 2022 Jan;10(1):11-12
pubmed: 34415678
Fertil Steril. 2020 Jun;113(6):1135-1139
pubmed: 32482249
Arab J Urol. 2021 May 29;19(3):264-273
pubmed: 34552778
Andrologia. 2022 Jun;54(5):e14385
pubmed: 35102599
Iran J Microbiol. 2021 Aug;13(4):434-441
pubmed: 34557270
BMJ. 2020 Mar 26;368:m1198
pubmed: 32217618
Reprod Biol Endocrinol. 2021 May 13;19(1):69
pubmed: 33985514
Fertil Steril. 2022 Feb;117(2):287-296
pubmed: 34937665
Drug Dev Res. 2020 Nov;81(7):771-776
pubmed: 32412125
Cochrane Database Syst Rev. 2014;(12):CD007411
pubmed: 25504418
Fertil Steril. 2020 Aug;114(2):233-238
pubmed: 32650948
J Assist Reprod Genet. 2021 Nov;38(11):3005-3013
pubmed: 34455507
Braz J Med Biol Res. 2022 Feb 16;55:e11711
pubmed: 35195196
Andrologia. 2021 Mar;53(2):e13912
pubmed: 33244788
J Med Virol. 2021 Jan;93(1):456-462
pubmed: 32621617
J Sex Med. 2021 May;18(5):843-848
pubmed: 33903045
Infect Dis Rep. 2021 Feb 04;13(1):96-101
pubmed: 33557147
World J Clin Pediatr. 2023 Jun 9;12(3):57-67
pubmed: 37342451
Prostaglandins Leukot Essent Fatty Acids. 2000 Sep;63(3):159-65
pubmed: 10991774
Reprod Fertil. 2020 Dec 23;1(1):67-81
pubmed: 35128424
Am J Mens Health. 2021 Mar-Apr;15(2):15579883211011371
pubmed: 33906513
Int J Infect Dis. 2021 Jul;108:244-251
pubmed: 34023492
Andrologia. 1998 Nov;30(6):325-9
pubmed: 9835946
Lancet. 2000 Apr 1;355(9210):1179-80
pubmed: 10791396
Andrologia. 2022 Jul;54(6):e14483
pubmed: 35610731
Urol Int. 2020;104(9-10):678-683
pubmed: 32781456
Reprod Sci. 2021 Jan;28(1):23-26
pubmed: 32651900
J Assist Reprod Genet. 2021 Apr;38(4):785-789
pubmed: 33660204
Arab J Urol. 2017 Dec 08;16(1):35-43
pubmed: 29713534
Nature. 2020 May;581(7807):221-224
pubmed: 32225175
Curr Pharm Des. 2021;27(24):2796-2801
pubmed: 33563149
Chest. 2021 Jan;159(1):108-111
pubmed: 32710890
Can Urol Assoc J. 2022 Nov;16(11):E558-E562
pubmed: 35704934
JAMA. 2021 Jul 20;326(3):273-274
pubmed: 34137808
J Am Acad Dermatol. 2020 Jul;83(1):308-309
pubmed: 32283245
Am J Clin Nutr. 1992 Jul;56(1):148-57
pubmed: 1609752
Andrology. 2022 Jan;10(1):34-41
pubmed: 34409772
J Androl. 2005 May-Jun;26(3):349-53
pubmed: 15867002
Arch Ital Urol Androl. 2023 Mar 13;95(1):11157
pubmed: 36924370
F S Rep. 2022 Sep;3(3):211-213
pubmed: 35936108
Middle East Fertil Soc J. 2022;27(1):14
pubmed: 35730047
Int J Gynaecol Obstet. 2022 Jul;158(1):116-120
pubmed: 35128663
Eur Urol. 2021 Nov;80(5):603-620
pubmed: 34511305
Andrologia. 2019 Feb;51(1):e13162
pubmed: 30259539
APMIS. 2022 May;130(5):243-252
pubmed: 35114008
Aging Male. 2019 Jun;22(2):129-140
pubmed: 29925283
Basic Clin Androl. 2022 Aug 2;32(1):13
pubmed: 35915409
Andrology. 2021 Jul;9(4):1060-1065
pubmed: 33851521
Nutrients. 2020 Aug 07;12(8):
pubmed: 32784601
Fertil Steril. 1984 Dec;42(6):890-4
pubmed: 6500080
Eur J Contracept Reprod Health Care. 2020 Oct;25(5):405-406
pubmed: 32643968
Front Med (Lausanne). 2021 Jan 13;7:563893
pubmed: 33521006
Hum Reprod Open. 2021 Mar 03;2021(1):hoab007
pubmed: 33718624
Hum Reprod. 1999 Apr;14(4):1028-33
pubmed: 10221237
Aust N Z J Obstet Gynaecol. 2007 Jun;47(3):216-21
pubmed: 17550489
Adv Exp Med Biol. 2017;1034:163-178
pubmed: 29256131
Urologia. 2023 Jun 5;:3915603231175941
pubmed: 37278004
Transl Androl Urol. 2022 Jan;11(1):110-115
pubmed: 35242646
Indian J Clin Biochem. 2021 Oct;36(4):427-439
pubmed: 33814753
Curr Pharm Des. 2021;27(24):2757-2769
pubmed: 32294030
Apoptosis. 2021 Aug;26(7-8):415-430
pubmed: 34076792
J Basic Clin Physiol Pharmacol. 2020 Sep 7;31(6):
pubmed: 32889794
Urology. 2022 Jun;164:33-39
pubmed: 35007621
J Sex Med. 2021 Feb;18(2):256-264
pubmed: 33468445
Fertil Steril. 2009 May;91(5):1785-92
pubmed: 18395716
Antioxidants (Basel). 2021 Sep 27;10(10):
pubmed: 34679669
Cochrane Database Syst Rev. 2019 Mar 14;3:CD007411
pubmed: 30866036
Hum Reprod. 2021 May 17;36(6):1520-1529
pubmed: 33522572
World J Mens Health. 2021 Jul;39(3):489-495
pubmed: 33663031
Andrology. 2021 Jan;9(1):99-106
pubmed: 33150723
Reprod Biol Endocrinol. 2021 Jul 5;19(1):102
pubmed: 34225767
Andrology. 2022 Sep;10(6):1016-1022
pubmed: 35713410
Andrology. 2022 Jan;10(1):24-33
pubmed: 34288536
EClinicalMedicine. 2020 Nov;28:100604
pubmed: 33134901
Fertil Steril. 2020 Mar;113(3):552-560.e3
pubmed: 32111479
Andrologia. 2021 Mar;53(2):e13953
pubmed: 33405232
JBRA Assist Reprod. 2021 Feb 02;25(1):76-80
pubmed: 32598834
Int J Mol Sci. 2020 Dec 23;22(1):
pubmed: 33374605
Hum Fertil (Camb). 2023 Feb;26(1):182-185
pubmed: 33439057
Andrology. 2022 Jan;10(1):8-10
pubmed: 34411453
Front Public Health. 2022 Feb 02;10:839967
pubmed: 35186854
Aging Male. 2020 Dec;23(5):1493-1503
pubmed: 32883151
Biol Reprod. 2020 Jun 23;103(1):4-6
pubmed: 32297920
Endocrine. 2023 Feb;79(2):243-251
pubmed: 36260234
Am J Mens Health. 2021 Sep-Oct;15(5):15579883211036790
pubmed: 34515581
Int J Environ Res Public Health. 2022 Apr 26;19(9):
pubmed: 35564672
Andrology. 2021 Jan;9(1):19-22
pubmed: 32369678
J Endocrinol Invest. 2021 Feb;44(2):223-231
pubmed: 32661947
Antioxidants (Basel). 2021 May 30;10(6):
pubmed: 34070761
Andrology. 2022 Sep;10(6):1047-1056
pubmed: 35124885
PLoS One. 2021 Dec 14;16(12):e0260187
pubmed: 34905541
Reprod Biomed Online. 2022 Apr;44(4):685-688
pubmed: 35279377
Reprod Biomed Online. 2014 Jul;29(1):32-58
pubmed: 24813754
J Endocrinol Invest. 2022 Jan;45(1):209-214
pubmed: 34191258
Andrology. 2021 Jan;9(1):88-98
pubmed: 32436355
Reprod Sci. 2021 Oct;28(10):2735-2742
pubmed: 33415647
Am J Clin Nutr. 2020 Jun 1;111(6):1297-1299
pubmed: 32342979
Open Forum Infect Dis. 2020 Aug 07;7(8):ofaa325
pubmed: 32875005
Antioxidants (Basel). 2021 Jul 01;10(7):
pubmed: 34356300
JAMA Netw Open. 2020 May 1;3(5):e208292
pubmed: 32379329
Bull Exp Biol Med. 2022 Sep;173(5):606-610
pubmed: 36210413
Cell. 2020 Apr 16;181(2):271-280.e8
pubmed: 32142651
Biol Reprod. 2006 Feb;74(2):410-6
pubmed: 16237152
Natl Sci Rev. 2020 Sep;7(9):1414-1418
pubmed: 34192086
Andrology. 2021 Jan;9(1):42-47
pubmed: 32598557
Nature. 2020 May;581(7807):215-220
pubmed: 32225176
Andrologia. 2018 Apr;50(3):
pubmed: 29315686
Front Public Health. 2020 Apr 29;8:152
pubmed: 32411652
Reprod Biomed Online. 2007 Apr;14(4):418-21
pubmed: 17425820
Urol Int. 2021;105(9-10):743-748
pubmed: 34265771
Reprod Biol Endocrinol. 2019 Feb 16;17(1):24
pubmed: 30771790
Physiol Res. 2022 Mar 25;71(1):47-54
pubmed: 35043653