Cross-Talk of NADPH Oxidases and Inflammation in Obesity.
COVID-19
antioxidants
cardiometabolic diseases
inflammation
non-alcoholic fatty liver disease
obesity
oxidative stress
reactive oxygen species
Journal
Antioxidants (Basel, Switzerland)
ISSN: 2076-3921
Titre abrégé: Antioxidants (Basel)
Pays: Switzerland
ID NLM: 101668981
Informations de publication
Date de publication:
09 Aug 2023
09 Aug 2023
Historique:
received:
30
06
2023
revised:
26
07
2023
accepted:
29
07
2023
medline:
26
8
2023
pubmed:
26
8
2023
entrez:
26
8
2023
Statut:
epublish
Résumé
Obesity is a major risk factor for cardiovascular and metabolic diseases. Multiple experimental and clinical studies have shown increased oxidative stress and inflammation linked to obesity. NADPH oxidases are major sources of reactive oxygen species in the cardiovascular system and in metabolically active cells and organs. An impaired balance due to the increased formation of reactive oxygen species and a reduced antioxidative capacity contributes to the pathophysiology of cardiovascular and metabolic diseases and is linked to inflammation as a major pathomechanism in cardiometabolic diseases. Non-alcoholic fatty liver disease is particularly characterized by increased oxidative stress and inflammation. In recent years, COVID-19 infections have also increased oxidative stress and inflammation in infected cells and tissues. Increasing evidence supports the idea of an increased risk for severe clinical complications of cardiometabolic diseases after COVID-19. In this review, we discuss the role of oxidative stress and inflammation in experimental models and clinical studies of obesity, cardiovascular diseases, COVID-19 infections and potential therapeutic strategies.
Identifiants
pubmed: 37627585
pii: antiox12081589
doi: 10.3390/antiox12081589
pmc: PMC10451527
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Subventions
Organisme : Deutsche Forschungsgemeinschaft (DFG)
ID : MO 1695/4-1 and 5-1; to H.M., IRTG 2251; to S.R.B. and H.M., Grant 47081312 to H.B.
Organisme : German Centre for Cardiovascular Research (DZHK)
ID : Grant 81X2800207 to H.M.
Organisme : Excellence Initiative by the German Federal and State Governments
ID : Institutional Strategy, measure 'support the best', 3-25 2, Grant F-03661-553-41B-1250000; to H.M.
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