Peripheral Vascular Disease and Carotid Artery Disease Are Associated with Decreased Bile Acid Excretion.
atherosclerosis
bile acids
carotid artery stenosis
low bile acid excretion
peripheral vascular disease
Journal
Bioengineering (Basel, Switzerland)
ISSN: 2306-5354
Titre abrégé: Bioengineering (Basel)
Pays: Switzerland
ID NLM: 101676056
Informations de publication
Date de publication:
07 Aug 2023
07 Aug 2023
Historique:
received:
21
05
2023
revised:
17
07
2023
accepted:
24
07
2023
medline:
26
8
2023
pubmed:
26
8
2023
entrez:
26
8
2023
Statut:
epublish
Résumé
Low bile acid excretion (BAE) is associated with a higher risk of coronary artery disease (CAD) and cerebrovascular disease (stroke). This study investigated BAE in patients with peripheral vascular disease (PVD) and carotid artery disease (CA) and those without these diseases, compared to patients with CAD, stroke, or no evidence of atherosclerosis. Patients with complaints of chest pain-suspected CAD, syncope, stroke/TIA, severe headache, intermittent claudication, or falls were enrolled. All received a 4-day standard diet with 490 mg of cholesterol and internal standard copper thiocyanate. Fecal BAE was measured using gas-liquid chromatography. One hundred and three patients, sixty-eight (66%) men and thirty-five women (34%), mean age range 60.9 ± 8.9 years, were enrolled in this prospective, 22-year follow-up study. Regression analysis showed that advanced age, total BAE, and excretion of the main fractions were the only significant independent factors that predicted prolonged survival (
Identifiants
pubmed: 37627820
pii: bioengineering10080935
doi: 10.3390/bioengineering10080935
pmc: PMC10451290
pii:
doi:
Types de publication
Journal Article
Langues
eng
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