Immunohistochemical Expression of Epithelial Cell Adhesion Molecule (EpCAM) in Salivary Gland Cancer: Correlation with the Biological Behavior.
EpCAM
biological behavior
perineural invasion
prognosis
salivary gland malignancy
Journal
Diagnostics (Basel, Switzerland)
ISSN: 2075-4418
Titre abrégé: Diagnostics (Basel)
Pays: Switzerland
ID NLM: 101658402
Informations de publication
Date de publication:
11 Aug 2023
11 Aug 2023
Historique:
received:
19
07
2023
revised:
05
08
2023
accepted:
07
08
2023
medline:
26
8
2023
pubmed:
26
8
2023
entrez:
26
8
2023
Statut:
epublish
Résumé
Salivary gland neoplasms comprise a diverse group of tumors with different biological behaviors and clinical outcomes. Understanding the underlying molecular alterations associated with these malignancies is critical for accurate diagnosis, prognosis, and treatment strategies. Among the many biomarkers under investigation, epithelial cell adhesion molecule (EpCAM) has emerged as a promising candidate in salivary gland cancer research. This article aims to provide a comprehensive overview of the differential expression of EpCAM in salivary gland cancer and its potential correlation with the biological behavior of these tumors. The clinical characteristics of 65 patients with salivary gland malignancy of different histopathological subtypes were included. We report the differential expression of EpCAM and the relationship between the clinical and histopathologic features of these tumors. Regarding the evaluation of the effect of EpCAM expression on survival, in our study, we showed that tumors with high EpCAM expression had reduced disease-free survival (DFS) and overall survival (OS) (
Identifiants
pubmed: 37627911
pii: diagnostics13162652
doi: 10.3390/diagnostics13162652
pmc: PMC10453306
pii:
doi:
Types de publication
Journal Article
Langues
eng
Références
Cancer. 2012 Aug 15;118(16):3928-36
pubmed: 22180391
J Biomed Sci. 2020 Jan 2;27(1):1
pubmed: 31894001
ESMO Open. 2022 Dec;7(6):100602
pubmed: 36567082
Int J Oral Maxillofac Surg. 2012 Aug;41(8):952-7
pubmed: 22647764
Exp Hematol Oncol. 2022 Nov 11;11(1):97
pubmed: 36369033
Int J Mol Sci. 2017 Aug 18;18(8):
pubmed: 28820475
World J Gastroenterol. 2005 Jan 21;11(3):344-7
pubmed: 15637741
Ann Diagn Pathol. 2016 Oct;24:62-7
pubmed: 27649957
Cancer Res. 2004 Aug 15;64(16):5818-24
pubmed: 15313925
Neoplasia. 2018 Jul;20(7):657-667
pubmed: 29800815
Laryngoscope. 1986 Oct;96(10):1139-44
pubmed: 3762288
Nat Commun. 2014 Aug 28;5:4764
pubmed: 25163760
Pathology. 2018 Dec;50(7):737-741
pubmed: 30389218
Otolaryngol Head Neck Surg. 2018 Jun;158(6):1035-1041
pubmed: 29337642
Cancer Treat Rev. 2012 Feb;38(1):68-75
pubmed: 21576002
Mod Pathol. 2006 Apr;19(4):514-23
pubmed: 16554731
Hum Pathol. 1998 Feb;29(2):166-9
pubmed: 9490276
Front Biosci. 2008 Jan 01;13:3096-100
pubmed: 17981779
Head Neck. 2015 Jul;37(7):1038-45
pubmed: 24710845
Antibodies (Basel). 2020 Jul 20;9(3):
pubmed: 32698317
Br J Oral Maxillofac Surg. 2009 Dec;47(8):587-93
pubmed: 19409681
Oral Oncol. 2005 Mar;41(3):328-35
pubmed: 15743696
Cancer. 1991 Dec 1;68(11):2431-7
pubmed: 1933780
Int J Clin Exp Pathol. 2011 Apr;4(4):336-48
pubmed: 21577319
Oral Oncol. 2008 Nov;44(11):1026-31
pubmed: 18396442
Cell Stress. 2019 May 21;3(6):165-180
pubmed: 31225512
Mod Pathol. 1990 Jan;3(1):76-82
pubmed: 2308924
J Clin Pathol. 2011 May;64(5):415-20
pubmed: 21415054
Oncol Rep. 2007 Dec;18(6):1413-6
pubmed: 17982624
J Neurol Surg B Skull Base. 2016 Apr;77(2):86-95
pubmed: 27123384
Int J Radiat Oncol Biol Phys. 2008 Apr 1;70(5):1365-72
pubmed: 18029108
AJNR Am J Neuroradiol. 1998 Apr;19(4):701-6
pubmed: 9576658
Anticancer Res. 1998 Sep-Oct;18(5B):3669-75
pubmed: 9854475
J Oral Maxillofac Surg. 2017 Jul;75(7):1542-1548
pubmed: 28041842
Br J Cancer. 2006 Jan 16;94(1):128-35
pubmed: 16404366
Int J Radiat Oncol Biol Phys. 1995 Jun 15;32(3):619-26
pubmed: 7790247
Oral Oncol. 2009 Nov;45(11):936-40
pubmed: 19692291
Braz J Otorhinolaryngol. 2015 May-Jun;81(3):329-35
pubmed: 25962319
Cancer. 1973 Jan;31(1):117-29
pubmed: 4345606
Clin Otolaryngol. 2009 Dec;34(6):539-45
pubmed: 20070763