Weight Loss Is a Strong Predictor of Memory Disorder Independent of Genetic Influences.
APOE
body mass index
dementia
memory disorder
weight loss
Journal
Genes
ISSN: 2073-4425
Titre abrégé: Genes (Basel)
Pays: Switzerland
ID NLM: 101551097
Informations de publication
Date de publication:
31 07 2023
31 07 2023
Historique:
received:
30
06
2023
revised:
26
07
2023
accepted:
27
07
2023
medline:
28
8
2023
pubmed:
26
8
2023
entrez:
26
8
2023
Statut:
epublish
Résumé
Past studies identified a link between weight loss and dementia, but lacked consistent conclusions. We sought to establish this link by examining the weight change profiles before and after dementia diagnosis. Using data from the Health and Retirement Study (1996-2020), we examined 13,123 participants. We conducted a nested case-control analysis to assess differences in biennial weight change profile while controlling for BMI, longevity polygenic risk scores, and Participants with a memory disorder lost weight (-0.63%) biennially, whereas those without a diagnosis did not (+0.013%, We observe that weight loss in dementia is a physiological process independent of genetic factors associated with BMI and longevity. Pre-dementia weight loss may be an important prognostic criterion to assess a person's risk of developing a memory disorder.
Sections du résumé
BACKGROUND
Past studies identified a link between weight loss and dementia, but lacked consistent conclusions. We sought to establish this link by examining the weight change profiles before and after dementia diagnosis.
METHODS
Using data from the Health and Retirement Study (1996-2020), we examined 13,123 participants. We conducted a nested case-control analysis to assess differences in biennial weight change profile while controlling for BMI, longevity polygenic risk scores, and
RESULTS
Participants with a memory disorder lost weight (-0.63%) biennially, whereas those without a diagnosis did not (+0.013%,
CONCLUSIONS
We observe that weight loss in dementia is a physiological process independent of genetic factors associated with BMI and longevity. Pre-dementia weight loss may be an important prognostic criterion to assess a person's risk of developing a memory disorder.
Identifiants
pubmed: 37628615
pii: genes14081563
doi: 10.3390/genes14081563
pmc: PMC10454755
pii:
doi:
Substances chimiques
Apolipoproteins E
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : BLRD VA
ID : I01 BX000933
Pays : United States
Organisme : NIA NIH HHS
ID : U01 AG009740
Pays : United States
Organisme : NIA NIH HHS
ID : RC4 AG039029
Pays : United States
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