Skin Gene Expression Profiles in Systemic Sclerosis: From Clinical Stratification to Precision Medicine.
SSc
fibrosis
scleroderma
skin gene expression
systemic sclerosis
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
08 Aug 2023
08 Aug 2023
Historique:
received:
13
07
2023
revised:
03
08
2023
accepted:
06
08
2023
medline:
28
8
2023
pubmed:
26
8
2023
entrez:
26
8
2023
Statut:
epublish
Résumé
Systemic sclerosis, also known as scleroderma or SSc, is a condition characterized by significant heterogeneity in clinical presentation, disease progression, and response to treatment. Consequently, the design of clinical trials to successfully identify effective therapeutic interventions poses a major challenge. Recent advancements in skin molecular profiling technologies and stratification techniques have enabled the identification of patient subgroups that may be relevant for personalized treatment approaches. This narrative review aims at providing an overview of the current status of skin gene expression analysis using computational biology approaches and highlights the benefits of stratifying patients upon their skin gene signatures. Such stratification has the potential to lead toward a precision medicine approach in the management of SSc.
Identifiants
pubmed: 37628728
pii: ijms241612548
doi: 10.3390/ijms241612548
pmc: PMC10454358
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Marche Biobank Project
ID : POR FESR 2014-2020
Références
Ann Rheum Dis. 2021 Aug;80(8):1040-1047
pubmed: 34096881
Autoimmun Rev. 2023 Jun;22(6):103314
pubmed: 36918090
Fibrogenesis Tissue Repair. 2012 Jun 06;5(Suppl 1):S24
pubmed: 23259531
J Clin Invest. 2015 Jul 1;125(7):2795-807
pubmed: 26098215
J Invest Dermatol. 2013 Aug;133(8):1979-89
pubmed: 23677167
Nat Rev Rheumatol. 2018 Nov;14(11):657-673
pubmed: 30305700
Ann Rheum Dis. 2019 Jun;78(6):817-825
pubmed: 30952646
PLoS One. 2021 Apr 7;16(4):e0249687
pubmed: 33826640
PLoS One. 2018 Jun 20;13(6):e0199314
pubmed: 29924864
Front Med (Lausanne). 2017 Aug 18;4:120
pubmed: 28868289
Cell. 2014 Oct 23;159(3):676-90
pubmed: 25417114
World J Gastroenterol. 2007 Jun 14;13(22):3056-62
pubmed: 17589920
PLoS Comput Biol. 2011 Mar;7(3):e1001095
pubmed: 21390271
Sci Adv. 2022 Apr 29;8(17):eabn4776
pubmed: 35486723
Proc Natl Acad Sci U S A. 2003 Oct 14;100(21):12319-24
pubmed: 14530402
J Invest Dermatol. 2018 Jun;138(6):1301-1310
pubmed: 29391252
Adv Drug Deliv Rev. 2016 Feb 1;97:4-27
pubmed: 26562801
Ann Rheum Dis. 2020 Mar;79(3):379-386
pubmed: 31767698
Semin Immunopathol. 2015 Sep;37(5):501-9
pubmed: 26223504
Ann Rheum Dis. 2021 Feb;80(2):228-237
pubmed: 33028580
Rheumatology (Oxford). 2023 Jun 13;:
pubmed: 37310917
Autoimmun Rev. 2020 Mar;19(3):102458
pubmed: 31927087
Arthritis Rheumatol. 2018 Feb;70(2):308-316
pubmed: 29073351
Ann Rheum Dis. 2023 Sep;82(9):1191-1204
pubmed: 37328193
Rheumatology (Oxford). 2022 Dec 23;62(1):19-28
pubmed: 35751592
Int J Mol Sci. 2023 Jun 06;24(12):
pubmed: 37372943
Lancet. 2016 Nov 12;388(10058):2416-2430
pubmed: 27133972
Fibrogenesis Tissue Repair. 2012 Jun 06;5(Suppl 1):S19
pubmed: 23259845
Int J Mol Sci. 2022 Mar 31;23(7):
pubmed: 35409263
Arthritis Rheum. 2013 Nov;65(11):2737-47
pubmed: 24122180
Arthritis Res Ther. 2015 Aug 18;17:213
pubmed: 26283632
Arthritis Res Ther. 2015 Jun 13;17:159
pubmed: 26071192
Semin Immunopathol. 2015 Sep;37(5):519-28
pubmed: 26152639
PLoS One. 2008 Jul 16;3(7):e2696
pubmed: 18648520
PLoS Comput Biol. 2015 Jan 08;11(1):e1004005
pubmed: 25569146
Ann Rheum Dis. 2018 Sep;77(9):1362-1371
pubmed: 29853453
N Engl J Med. 2019 Jun 27;380(26):2518-2528
pubmed: 31112379
Dtsch Med Wochenschr. 2012 Jan;137(1-2):34-40
pubmed: 22180282
J Invest Dermatol. 2012 May;132(5):1363-73
pubmed: 22318389
Arthritis Rheumatol. 2015 Nov;67(11):3016-26
pubmed: 26238292
Ann Rheum Dis. 2022 Apr;81(4):516-523
pubmed: 34937693
JCI Insight. 2016 Dec 22;1(21):e89073
pubmed: 28018971
Rheumatology (Oxford). 2009 Jun;48 Suppl 3:iii14-8
pubmed: 19487217
Nat Med. 2022 Jul;28(7):1363-1371
pubmed: 35788174
JCI Insight. 2022 Sep 8;7(17):
pubmed: 35943798
Arthritis Rheumatol. 2019 Oct;71(10):1701-1710
pubmed: 30920766
Curr Med Res Opin. 2021 Nov;37(sup2):5-15
pubmed: 34726112
Methods Mol Biol. 2017;1627:1-23
pubmed: 28836191
Ann Rheum Dis. 2016 Aug;75(8):1521-6
pubmed: 26338038
Arthritis Care Res (Hoboken). 2016 Mar;68(3):366-73
pubmed: 26223810
Arthritis Rheum. 2009 Feb;60(2):584-91
pubmed: 19180499
PLoS One. 2011;6(9):e23082
pubmed: 21931594
N Engl J Med. 2019 Oct 31;381(18):1718-1727
pubmed: 31566307
Arthritis Rheumatol. 2021 Oct;73(10):1921-1930
pubmed: 33844442
JAMA Dermatol. 2023 Aug 1;159(8):837-847
pubmed: 37378994
Nat Commun. 2019 Oct 31;10(1):4955
pubmed: 31672989
J Am Acad Dermatol. 2023 Aug;89(2):366-369
pubmed: 36997069
BMC Med. 2013 Jan 11;11:9
pubmed: 23311619
Arthritis Rheumatol. 2018 Jun;70(6):912-919
pubmed: 29858547
J Clin Invest. 2018 Jan 2;128(1):45-53
pubmed: 29293088