Blood-Brain Barrier Breakdown in Neuroinflammation: Current In Vitro Models.


Journal

International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791

Informations de publication

Date de publication:
11 Aug 2023
Historique:
received: 21 06 2023
revised: 07 08 2023
accepted: 08 08 2023
medline: 28 8 2023
pubmed: 26 8 2023
entrez: 26 8 2023
Statut: epublish

Résumé

The blood-brain barrier, which is formed by tightly interconnected microvascular endothelial cells, separates the brain from the peripheral circulation. Together with other central nervous system-resident cell types, including pericytes and astrocytes, the blood-brain barrier forms the neurovascular unit. Upon neuroinflammation, this barrier becomes leaky, allowing molecules and cells to enter the brain and to potentially harm the tissue of the central nervous system. Despite the significance of animal models in research, they may not always adequately reflect human pathophysiology. Therefore, human models are needed. This review will provide an overview of the blood-brain barrier in terms of both health and disease. It will describe all key elements of the in vitro models and will explore how different compositions can be utilized to effectively model a variety of neuroinflammatory conditions. Furthermore, it will explore the existing types of models that are used in basic research to study the respective pathologies thus far.

Identifiants

pubmed: 37628879
pii: ijms241612699
doi: 10.3390/ijms241612699
pmc: PMC10454051
pii:
doi:

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

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Auteurs

Sarah Brandl (S)

Clinical Department of Neurology, Medical University of Innsbruck, 6020 Innsbruck, Austria.

Markus Reindl (M)

Clinical Department of Neurology, Medical University of Innsbruck, 6020 Innsbruck, Austria.

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