Circulating Sphingolipids and Glucose Homeostasis: An Update.
biomarkers
ceramides
extracellular vesicles
lipoproteins
sphingosine-1-phosphate
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
12 Aug 2023
12 Aug 2023
Historique:
received:
30
06
2023
revised:
07
08
2023
accepted:
08
08
2023
medline:
28
8
2023
pubmed:
26
8
2023
entrez:
26
8
2023
Statut:
epublish
Résumé
Sphingolipids are a family of lipid molecules produced through different pathways in mammals. Sphingolipids are structural components of membranes, but in response to obesity, they are implicated in the regulation of various cellular processes, including inflammation, apoptosis, cell proliferation, autophagy, and insulin resistance which favors dysregulation of glucose metabolism. Of all sphingolipids, two species, ceramides and sphingosine-1-phosphate (S1P), are also found abundantly secreted into the bloodstream and associated with lipoproteins or extracellular vesicles. Plasma concentrations of these sphingolipids can be altered upon metabolic disorders and could serve as predictive biomarkers of these diseases. Recent important advances suggest that circulating sphingolipids not only serve as biomarkers but could also serve as mediators in the dysregulation of glucose homeostasis. In this review, advances of molecular mechanisms involved in the regulation of ceramides and S1P association to lipoproteins or extracellular vesicles and how they could alter glucose metabolism are discussed.
Identifiants
pubmed: 37628901
pii: ijms241612720
doi: 10.3390/ijms241612720
pmc: PMC10454113
pii:
doi:
Substances chimiques
Sphingolipids
0
Ceramides
0
sphingosine 1-phosphate
26993-30-6
Glucose
IY9XDZ35W2
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Références
Cardiovasc Diabetol. 2022 Aug 30;21(1):167
pubmed: 36042511
Int J Mol Sci. 2020 Sep 02;21(17):
pubmed: 32887221
Dig Dis. 2012;30(2):158-62
pubmed: 22722431
Expert Opin Ther Targets. 2015;19(8):1037-50
pubmed: 25814122
Diabetologia. 2001 Feb;44(2):173-83
pubmed: 11270673
Diabetes Res Clin Pract. 2021 Mar;173:108699
pubmed: 33592213
Endocr Rev. 2006 May;27(3):242-59
pubmed: 16492903
Cell Rep Med. 2020 Dec 22;1(9):100154
pubmed: 33377125
J Extracell Vesicles. 2022 Jun;11(6):e12233
pubmed: 35642450
Nature. 2014 Jun 5;510(7503):58-67
pubmed: 24899305
J Biol Chem. 2018 Sep 28;293(39):15277-15289
pubmed: 30139741
Gastroenterology. 2016 Apr;150(4):956-67
pubmed: 26764184
Cell Metab. 2018 Feb 6;27(2):276-280
pubmed: 29307517
EBioMedicine. 2019 Mar;41:44-49
pubmed: 30594552
Cell Physiol Biochem. 2014;34(1):134-47
pubmed: 24977487
J Clin Invest. 2022 Apr 1;132(7):
pubmed: 35104242
Nat Rev Immunol. 2014 Mar;14(3):195-208
pubmed: 24566916
Cell Rep. 2023 Mar 28;42(3):112169
pubmed: 36862553
Cells. 2020 Jul 13;9(7):
pubmed: 32668665
Diabetes. 2020 May;69(5):867-881
pubmed: 31915150
Hepatology. 2013 Feb;57(2):525-32
pubmed: 22911490
Cell Metab. 2018 Oct 2;28(4):605-618.e6
pubmed: 29909971
Diabetes. 2004 May;53(5):1215-21
pubmed: 15111489
Eur Heart J. 2016 Jul 01;37(25):1967-76
pubmed: 27125947
Biochem J. 2012 Feb 1;441(3):789-802
pubmed: 22248339
J Lipid Res. 2021;62:100119
pubmed: 34555371
Med. 2022 Jul 8;3(7):440-441
pubmed: 35809557
JCI Insight. 2018 Apr 19;3(8):
pubmed: 29669945
Curr Opin Lipidol. 2019 Jun;30(3):212-217
pubmed: 31008738
Cell Physiol Biochem. 2016;40(5):1207-1220
pubmed: 27960149
Front Immunol. 2018 Dec 19;9:2980
pubmed: 30619336
World J Diabetes. 2014 Jun 15;5(3):244-57
pubmed: 24936246
BMC Cancer. 2018 Jan 6;18(1):47
pubmed: 29306323
Diabetes. 2013 Feb;62(2):401-10
pubmed: 23139352
Lancet Diabetes Endocrinol. 2022 Jul;10(7):488
pubmed: 35662402
J Clin Invest. 2010 Dec;120(12):4342-52
pubmed: 21041950
Science. 2008 Feb 29;319(5867):1244-7
pubmed: 18309083
Stem Cell Res. 2010 May;4(3):214-22
pubmed: 20138817
Cells. 2022 Mar 01;11(5):
pubmed: 35269467
Cell Metab. 2014 Oct 7;20(4):687-95
pubmed: 25295789
Int J Mol Sci. 2019 Jan 23;20(3):
pubmed: 30678043
Nature. 2012 Jan 09;481(7382):525-9
pubmed: 22230960
Mol Cells. 2022 Nov 30;45(11):771-780
pubmed: 36380729
Mol Cell Biol. 2003 Nov;23(21):7794-808
pubmed: 14560023
Arch Cardiol Mex. 2023;93(1):88-95
pubmed: 36757794
Endocrinology. 2009 Oct;150(10):4521-30
pubmed: 19628574
Sci Signal. 2013 Oct 08;6(296):ra88
pubmed: 24106341
J Clin Endocrinol Metab. 2001 Dec;86(12):5755-61
pubmed: 11739435
JHEP Rep. 2023 Apr 07;5(8):100756
pubmed: 37360906
Proc Natl Acad Sci U S A. 2011 Jun 7;108(23):9613-8
pubmed: 21606363
Biomedicines. 2022 Aug 12;10(8):
pubmed: 36009503
J Lipid Res. 2018 Aug;59(8):1325-1340
pubmed: 29853528
PLoS One. 2014 Jul 24;9(7):e101865
pubmed: 25058613
Cell Signal. 2021 Jun;82:109959
pubmed: 33631318
Nat Rev Endocrinol. 2020 Apr;16(4):224-233
pubmed: 32060415
Endocrinol Diabetes Metab. 2023 May;6(3):e418
pubmed: 36952350
Mol Cell Biol. 1998 Sep;18(9):5457-64
pubmed: 9710629
J Clin Med. 2021 Feb 16;10(4):
pubmed: 33669443
J Biol Chem. 2003 May 16;278(20):18368-75
pubmed: 12594227
Front Immunol. 2014 Aug 04;5:370
pubmed: 25136343
J Biol Chem. 2003 Mar 21;278(12):10297-303
pubmed: 12525490
Biochim Biophys Acta. 2014 Sep;1841(9):1217-26
pubmed: 24814049
Gastroenterology. 2012 Aug;143(2):448-58
pubmed: 22537612
Biochem J. 2003 Dec 15;376(Pt 3):697-705
pubmed: 14505487
Circ Res. 2020 May 22;126(11):1477-1500
pubmed: 32437302
J Lipid Res. 2009 Mar;50(3):574-585
pubmed: 18832345
Diabetologia. 2012 Oct;55(10):2741-2746
pubmed: 22854889
Antioxidants (Basel). 2023 Jan 06;12(1):
pubmed: 36671005
Lipids. 1999;34 Suppl:S85-8
pubmed: 10419100
Arch Biochem Biophys. 2003 Nov 15;419(2):120-8
pubmed: 14592455
Cell Rep. 2018 Jan 2;22(1):175-188
pubmed: 29298420
J Biol Chem. 2014 Jan 17;289(3):1688-703
pubmed: 24293365
Mol Membr Biol. 2001 Jul-Sep;18(3):195-204
pubmed: 11681786
J Biol Chem. 2016 Feb 5;291(6):3019-29
pubmed: 26698173
Int J Mol Sci. 2023 Apr 24;24(9):
pubmed: 37175451
Biochem J. 2004 Sep 1;382(Pt 2):619-29
pubmed: 15193147
J Biol Chem. 2010 Apr 2;285(14):10911-23
pubmed: 20110366
Diabetes. 2009 Feb;58(2):337-43
pubmed: 19008343
Front Med (Lausanne). 2020 Aug 11;7:395
pubmed: 32850903
J Cell Sci. 2007 Feb 1;120(Pt 3):407-16
pubmed: 17213336
Metabolomics. 2019 Oct 11;15(11):140
pubmed: 31605240
Int J Mol Sci. 2019 Feb 18;20(4):
pubmed: 30781611
Langenbecks Arch Surg. 2023 Feb 24;408(1):101
pubmed: 36826628
Curr Opin Lipidol. 2022 Jun 1;33(3):199-207
pubmed: 35695616
Molecules. 2020 Apr 23;25(8):
pubmed: 32340373
Biochem Pharmacol. 2022 Aug;202:115157
pubmed: 35777449
Science. 2023 Mar 17;379(6637):1080-1083
pubmed: 36927023
J Biol Chem. 2010 Apr 2;285(14):10902-10
pubmed: 20110363
Endocrinol Metab Clin North Am. 2023 Mar;52(1):149-164
pubmed: 36754491
Diabetes. 2002 Jan;51(1):7-18
pubmed: 11756317
J Nutr. 2020 May 1;150(5):1214-1222
pubmed: 31665380
Biomed Res Int. 2015;2015:165105
pubmed: 25866760
Obes Rev. 2021 Aug;22(8):e13248
pubmed: 33738905
Atherosclerosis. 2006 Jul;187(1):57-64
pubmed: 16183064
J Clin Endocrinol Metab. 2010 Dec;95(12):5449-53
pubmed: 20843949
J Atheroscler Thromb. 2021 Jul 1;28(7):730-741
pubmed: 32999208
Acta Neuropathol. 2021 Dec;142(6):961-984
pubmed: 34514546
Cell Metab. 2015 Aug 4;22(2):266-278
pubmed: 26190650
Endocrinol Metab Clin North Am. 2022 Sep;51(3):437-458
pubmed: 35963623
EMBO Rep. 2020 Sep 3;21(9):e49828
pubmed: 32672883
Nat Commun. 2022 Apr 1;13(1):1748
pubmed: 35365625
Cell Rep. 2017 Feb 28;18(9):2269-2279
pubmed: 28249170
J Diabetes Investig. 2020 Sep;11(5):1150-1158
pubmed: 32243104
J Lipid Res. 2016 Feb;57(2):233-45
pubmed: 26621917
Diabetes. 2018 Jul;67(7):1258-1271
pubmed: 29759974
Membranes (Basel). 2021 Aug 12;11(8):
pubmed: 34436382
Proc Jpn Acad Ser B Phys Biol Sci. 2010;86(4):426-37
pubmed: 20431265
J Lipid Atheroscler. 2021 Sep;10(3):268-281
pubmed: 34621698
Gastroenterology. 2020 Oct;159(4):1487-1503.e17
pubmed: 32574624
Diabetes. 2010 Mar;59(3):600-10
pubmed: 19959757
J Atheroscler Thromb. 2004;11(4):200-8
pubmed: 15356379
Metabolites. 2021 Nov 28;11(12):
pubmed: 34940565
J Biol Chem. 2023 Jun;299(6):104815
pubmed: 37178918
J Biochem Mol Biol. 2006 Mar 31;39(2):113-31
pubmed: 16584625
Med. 2022 Jul 8;3(7):452-467.e4
pubmed: 35709767
J Lipid Res. 2020 Apr;61(4):492-504
pubmed: 31907205
Front Endocrinol (Lausanne). 2020 Aug 07;11:491
pubmed: 32849282
Cell Metab. 2023 Mar 7;35(3):414-428.e3
pubmed: 36889281
Diabetologia. 2018 Dec;61(12):2570-2579
pubmed: 30159588
Annu Rev Physiol. 2021 Feb 10;83:303-330
pubmed: 33158378
Mol Metab. 2019 Mar;21:36-50
pubmed: 30655217
J Am Heart Assoc. 2022 Apr 5;11(7):e022852
pubmed: 35301857
Diabetologia. 2014 Oct;57(10):2155-64
pubmed: 25073444
J Biol Chem. 2015 Oct 23;290(43):25863-75
pubmed: 26350457
J Hepatol. 2016 Jan;64(1):60-8
pubmed: 26254847
J Intern Med. 2010 Mar;267(3):316-21
pubmed: 19754856
Biomed Pharmacother. 2021 May;137:111315
pubmed: 33561645
Diabetes. 2001 Nov;50(11):2563-71
pubmed: 11679435
Adv Cancer Res. 2018;140:27-60
pubmed: 30060813