The Post-Translational Modifications of Human Salivary Peptides and Proteins Evidenced by Top-Down Platforms.
post-translational modifications
salivary proteins
top-down proteomics
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
14 Aug 2023
14 Aug 2023
Historique:
received:
19
06
2023
revised:
05
08
2023
accepted:
08
08
2023
medline:
28
8
2023
pubmed:
26
8
2023
entrez:
26
8
2023
Statut:
epublish
Résumé
In this review, we extensively describe the main post-translational modifications that give rise to the multiple proteoforms characterized to date in the human salivary proteome and their potential role. Most of the data reported were obtained by our group in over twenty-five years of research carried out on human saliva mainly by applying a top-down strategy. In the beginning, we describe the products generated by proteolytic cleavages, which can occur before and after secretion. In this section, the most relevant families of salivary proteins are also described. Next, we report the current information concerning the human salivary phospho-proteome and the limited news available on sulfo-proteomes. Three sections are dedicated to the description of glycation and enzymatic glycosylation. Citrullination and N- and C-terminal post-translational modifications (PTMs) and miscellaneous other modifications are described in the last two sections. Results highlighting the variation in the level of some proteoforms in local or systemic pathologies are also reviewed throughout the sections of the manuscript to underline the impact and relevance of this information for the development of new diagnostic biomarkers useful in clinical practice.
Identifiants
pubmed: 37628956
pii: ijms241612776
doi: 10.3390/ijms241612776
pmc: PMC10454625
pii:
doi:
Substances chimiques
Proteome
0
Salivary Proteins and Peptides
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Références
Trends Biochem Sci. 2021 Jan;46(1):15-27
pubmed: 32912665
Front Neurosci. 2022 Nov 03;16:1000179
pubmed: 36408389
Mol Cell Proteomics. 2010 Oct;9(10):2099-108
pubmed: 20585025
J Proteome Res. 2018 Sep 7;17(9):3292-3307
pubmed: 30064219
Environ Health Prev Med. 2003 Jul;8(3):95-9
pubmed: 21432106
Arch Biochem Biophys. 2001 Jun 15;390(2):149-57
pubmed: 11396917
J Proteome Res. 2022 Jul 1;21(7):1589-1602
pubmed: 35715216
J Dent Res. 1986 Mar;65(3):405-11
pubmed: 3007590
PLoS One. 2012;7(2):e30962
pubmed: 22312435
Amino Acids. 2013 Jan;44(1):245-50
pubmed: 22080209
Talanta. 2021 Jan 15;222:121429
pubmed: 33167196
J Proteomics. 2016 Feb 16;134:47-56
pubmed: 26375204
Tohoku J Exp Med. 2000 Nov;192(3):219-25
pubmed: 11249151
J Proteome Res. 2007 Jul;6(7):2472-80
pubmed: 17503797
J Proteome Res. 2015 Apr 3;14(4):1666-77
pubmed: 25761918
PLoS Genet. 2011 Jul;7(7):e1002169
pubmed: 21750686
J Biochem. 1983 Dec;94(6):1991-9
pubmed: 6671974
J Proteome Res. 2008 Dec;7(12):5327-32
pubmed: 19367726
Anal Biochem. 2010 Dec 1;407(1):19-33
pubmed: 20659418
PLoS One. 2019 Sep 18;14(9):e0220208
pubmed: 31532774
J Proteome Res. 2020 Jan 3;19(1):300-313
pubmed: 31638822
Rev Clin Esp (Barc). 2021 Apr;221(4):233-240
pubmed: 33998505
Eur J Biochem. 2001 Jun;268(12):3423-31
pubmed: 11422372
Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2008 May;105(5):617-24
pubmed: 18206396
Anal Chem. 2017 Mar 21;89(6):3483-3491
pubmed: 28221766
Infect Immun. 1988 Feb;56(2):439-45
pubmed: 2892794
Pathol Biol (Paris). 2010 Jun;58(3):214-9
pubmed: 19896783
J Am Soc Mass Spectrom. 2010 Jun;21(6):908-17
pubmed: 20189825
Anal Bioanal Chem. 2022 May;414(12):3697-3708
pubmed: 35306568
PLoS One. 2022 Mar 23;17(3):e0265687
pubmed: 35320820
J Dent Res. 2000 Apr;79(4):976-82
pubmed: 10831101
J Immunol Res. 2019 Nov 25;2019:7592851
pubmed: 31886309
Molecules. 2021 Aug 30;26(17):
pubmed: 34500691
Eur J Oral Sci. 2005 Feb;113(1):2-13
pubmed: 15693823
J Proteome Res. 2017 Nov 3;16(11):4196-4207
pubmed: 29019242
Gene. 1990 May 14;89(2):245-51
pubmed: 2373369
Biochim Biophys Acta. 2003 Jan 31;1645(1):105-12
pubmed: 12535617
Biochem J. 1989 Aug 1;261(3):887-96
pubmed: 2572218
J Proteome Res. 2009 Aug;8(8):4126-34
pubmed: 19591489
Curr Mol Med. 2013 Jan;13(1):24-57
pubmed: 22834835
FEBS Lett. 2002 Feb 20;513(1):30-7
pubmed: 11911877
Adv Clin Chem. 2023;113:101-156
pubmed: 36858645
J Sep Sci. 2021 Oct;44(19):3677-3690
pubmed: 34350708
J Proteomics. 2012 Jan 4;75(3):908-13
pubmed: 22057043
Proteomics. 2003 Apr;3(4):461-7
pubmed: 12687613
Crit Rev Oral Biol Med. 1998;9(1):4-22
pubmed: 9488245
J Biol Chem. 2004 Oct 1;279(40):41436-43
pubmed: 15272024
J Biochem. 1979 Jul;86(1):79-86
pubmed: 479131
Eur J Biochem. 1990 Jul 20;191(1):47-56
pubmed: 2379503
J Oral Sci. 2011 Jun;53(2):147-56
pubmed: 21712618
Biomed Chromatogr. 2005 Apr;19(3):214-22
pubmed: 15484227
J Sep Sci. 2014 Jul;37(14):1896-902
pubmed: 24771659
Mol Cell Proteomics. 2011 Jan;10(1):M110.003467
pubmed: 20943598
Biomed Chromatogr. 2007 Nov;21(11):1107-17
pubmed: 17516463
Glycobiology. 2005 Jul;15(7):16R-28R
pubmed: 15764591
J Proteome Res. 2013 Feb 1;12(2):917-26
pubmed: 23278499
Proteomics. 2015 Jul;15(14):2385-401
pubmed: 25914051
Adv Exp Med Biol. 1998;443:57-63
pubmed: 9781343
Front Neurosci. 2021 May 26;15:668852
pubmed: 34121996
Sci Transl Med. 2021 Oct 20;13(616):eabe2352
pubmed: 34669441
ACS Infect Dis. 2023 Mar 10;9(3):450-458
pubmed: 36735927
Acta Biochim Biophys Sin (Shanghai). 2017 Jul 1;49(7):567-572
pubmed: 28472221
J Proteomics. 2014 May 30;103:15-22
pubmed: 24690516
J Proteome Res. 2004 Jul-Aug;3(4):792-800
pubmed: 15359733
J Biochem. 1983 Mar;93(3):883-8
pubmed: 6874669
Infect Immun. 2004 Feb;72(2):782-7
pubmed: 14742521
Mol Pharm. 2021 Aug 2;18(8):3116-3124
pubmed: 34232660
J Alzheimers Dis. 2022;89(2):605-622
pubmed: 35912740
Trends Biotechnol. 2011 Aug;29(8):409-18
pubmed: 21620493
Noncoding RNA Res. 2019 Oct 17;4(3):80-81
pubmed: 31891016
Arch Oral Biol. 1991;36(7):529-34
pubmed: 1663737
Clin Neuropharmacol. 2015 Jul-Aug;38(4):127-31
pubmed: 26166235
Proteomics. 2006 Jul;6(14):3993-4015
pubmed: 16786490
Cell Mol Life Sci. 2022 Jan 25;79(2):94
pubmed: 35079870
J Biol Chem. 2008 Jul 18;283(29):19957-66
pubmed: 18463091
Science. 2020 Sep 11;369(6509):1318-1330
pubmed: 32913098
J Biol Chem. 2013 Sep 13;288(37):26497-504
pubmed: 23861399
Trends Biochem Sci. 2013 Mar;38(3):121-30
pubmed: 23276407
J Biochem. 1991 Oct;110(4):648-54
pubmed: 1778989
FASEB J. 2017 Nov;31(11):4946-4958
pubmed: 28751526
J Texture Stud. 2019 Feb;50(1):19-26
pubmed: 30226267
Anal Chem. 2012 May 15;84(10):4383-95
pubmed: 22509742
IUBMB Life. 2003 Jan;55(1):1-11
pubmed: 12716056
Expert Rev Proteomics. 2010 Oct;7(5):709-21
pubmed: 20973643
J Biochem. 2000 Mar;127(3):393-8
pubmed: 10731710
Crit Rev Oral Biol Med. 1993;4(3-4):479-85
pubmed: 8374001
J Proteome Res. 2011 Apr 1;10(4):1728-36
pubmed: 21299198
Sci Rep. 2021 Jun 29;11(1):13525
pubmed: 34188155
Biochemistry. 1982 Dec 7;21(25):6558-62
pubmed: 6924859
J Proteome Res. 2006 Jun;5(6):1493-503
pubmed: 16740002
FASEB J. 1997 Mar;11(4):206-16
pubmed: 9068609
Acta Otorhinolaryngol Ital. 2010 Jun;30(3):125-30
pubmed: 20948587
Biochemistry. 2005 Mar 1;44(8):2885-99
pubmed: 15723531
Mol Cell Proteomics. 2008 May;7(5):911-26
pubmed: 18187409
Crit Rev Oral Biol Med. 1999;10(3):359-83
pubmed: 10759414
Arch Oral Biol. 1998 Sep;43(9):717-28
pubmed: 9783826
Proteomics. 2006 Dec;6(23):6370-9
pubmed: 17080484
Arch Oral Biol. 2004 Nov;49(11):871-9
pubmed: 15353242
J Biol Chem. 2003 Feb 14;278(7):5300-8
pubmed: 12444093
J Proteomics. 2018 Sep 15;187:212-222
pubmed: 30086402
PLoS One. 2016 Jan 27;11(1):e0147925
pubmed: 26814504
Int J Mol Sci. 2023 Jan 04;24(2):
pubmed: 36674470
Methods. 2022 Jul;203:90-102
pubmed: 34942356
Crit Rev Oral Biol Med. 2000;11(4):383-408
pubmed: 11132762
Diabetes Care. 1995 Jun;18(6):896-909
pubmed: 7555528
Biochim Biophys Acta. 2009 Jun;1793(6):993-1007
pubmed: 19121341
Pharmacol Res. 2019 Sep;147:104342
pubmed: 31288079
Drug Metab Dispos. 2022 Jul;50(7):1027-1041
pubmed: 35197313
J Dent Res. 2021 Dec;100(13):1510-1519
pubmed: 34032471
Science. 2001 Mar 23;291(5512):2364-9
pubmed: 11269317
Biochem Biophys Res Commun. 1969 Aug 22;36(5):838-43
pubmed: 5808299
J Biol Chem. 1992 Mar 25;267(9):5968-76
pubmed: 1313424
J Biol Chem. 2010 May 7;285(19):14377-88
pubmed: 20223829
Amino Acids. 2011 Oct;41(4):821-42
pubmed: 20213444
Arch Oral Biol. 2019 Dec;108:104510
pubmed: 31446118
Biol Chem Hoppe Seyler. 1996 Feb;377(2):71-86
pubmed: 8868064
J Sep Sci. 2016 May;39(10):1987-97
pubmed: 26991339
J Sep Sci. 2008 Jun;31(11):1948-63
pubmed: 18491358
Free Radic Biol Med. 2013 May;58:170-86
pubmed: 23277148
J Proteomics. 2020 Jun 30;222:103797
pubmed: 32360370
Arch Oral Biol. 2017 Aug;80:144-152
pubmed: 28419912
J Leukoc Biol. 2009 Sep;86(3):577-87
pubmed: 19237640
Med Clin (Barc). 2017 Oct 11;149(7):305-309
pubmed: 28669517
Biol Chem Hoppe Seyler. 1995 Feb;376(2):71-80
pubmed: 7794528
Proteomics. 2010 Oct;10(20):3732-42
pubmed: 20879038
Proteomics. 2005 Feb;5(3):805-15
pubmed: 15693058
Arthritis Res. 2000;2(4):249-51
pubmed: 11094435
Proteomics. 2023 Mar;23(5):e2200319
pubmed: 36573687
J Biol Chem. 2015 Jul 31;290(31):18991-8
pubmed: 26055713
Arch Oral Biol. 2018 May 18;93:22-30
pubmed: 29803117
Amino Acids. 2012 Feb;42(2-3):939-49
pubmed: 21818567
Clin Biochem. 2015 Jan;48(1-2):24-8
pubmed: 25304914
Arch Oral Biol. 1979;24(4):249-56
pubmed: 292368
Front Mol Neurosci. 2018 May 14;11:158
pubmed: 29867350
Nat Rev Mol Cell Biol. 2015 Dec;16(12):742-52
pubmed: 26465718
J Matern Fetal Neonatal Med. 2012 Oct;25(Suppl 5):27-43
pubmed: 23025766
Biochemistry. 2009 Jul 28;48(29):7072-8
pubmed: 19518051
PLoS One. 2022 Jan 21;17(1):e0262369
pubmed: 35061788
Free Radic Biol Med. 2015 Mar;80:148-57
pubmed: 25433365
Mol Cell Biochem. 1998 Apr;181(1-2):63-9
pubmed: 9562242
Nat Rev Cancer. 2015 Sep;15(9):540-55
pubmed: 26289314
J Biol Chem. 1988 Jun 5;263(16):7472-7
pubmed: 3286634
PLoS One. 2012;7(1):e29559
pubmed: 22242175
J Proteomics. 2013 Oct 08;91:536-43
pubmed: 23973467
Toxicol Sci. 2006 Mar;90(1):5-22
pubmed: 16322073
J Biol Chem. 1985 Sep 15;260(20):11123-30
pubmed: 2993301
J Alzheimers Dis. 2004 Oct;6(5):489-95
pubmed: 15505370
Crit Rev Biochem Mol Biol. 2018 Jun;53(3):246-263
pubmed: 29564928
Biol Chem. 2008 Aug;389(8):983-91
pubmed: 18979624
J Dent Res. 2012 Dec;91(12):1110-8
pubmed: 23018818
J Proteome Res. 2009 Feb;8(2):754-69
pubmed: 19093874
Expert Opin Drug Metab Toxicol. 2021 Jul;17(7):767-784
pubmed: 34107842
J Proteomics. 2015 Oct 14;128:154-63
pubmed: 26254010
Oncol Rep. 1998 Nov-Dec;5(6):1349-61
pubmed: 9769367
Immunol Rev. 2005 Aug;206:83-99
pubmed: 16048543
Cancer Res. 2018 Jan 1;78(1):15-29
pubmed: 29254998
J Sep Sci. 2012 May;35(9):1079-86
pubmed: 22689482
J Proteome Res. 2020 Aug 7;19(8):3238-3253
pubmed: 32575983
Biochem Biophys Res Commun. 2010 Jul 30;398(3):477-81
pubmed: 20599699
Cell. 2015 Jun 18;161(7):1619-32
pubmed: 26091039
Biochem Biophys Res Commun. 1989 Apr 28;160(2):495-502
pubmed: 2719677
Acta Otorhinolaryngol Ital. 2017 Apr;37(2):94-101
pubmed: 28516971
Bioanalysis. 2014 Feb;6(4):563-81
pubmed: 24568357
J Biochem. 1982 Jun;91(6):2067-75
pubmed: 7118863
J Dent Res. 2004 Jun;83(6):505-10
pubmed: 15153461
J Dent Res. 2007 Aug;86(8):680-93
pubmed: 17652194
Drug Metab Dispos. 2009 Nov;37(11):2255-61
pubmed: 19679676
Autoimmun Rev. 2010 Jan;9(3):158-60
pubmed: 19540364
Redox Biol. 2019 Jun;24:101202
pubmed: 31015146
Biochimie. 2015 Jul;114:134-46
pubmed: 25450248
Indian J Exp Biol. 2006 Mar;44(3):171-82
pubmed: 16538854
Eur J Oral Sci. 2001 Feb;109(1):60-8
pubmed: 11330936
J Inflamm Res. 2022 Mar 28;15:2051-2073
pubmed: 35378954
Biopolymers. 2016 Sep;106(5):714-25
pubmed: 27272460
Crit Rev Biochem Mol Biol. 1993;28(6):515-42
pubmed: 8299360
J Clin Immunol. 2020 Feb;40(2):329-339
pubmed: 31916122
Free Radic Biol Med. 2008 Sep 1;45(5):549-61
pubmed: 18544350
J Sep Sci. 2006 Nov;29(17):2600-8
pubmed: 17313100
PLoS One. 2011;6(9):e24455
pubmed: 21957450
Am J Hum Genet. 1987 Dec;41(6):1048-60
pubmed: 3502720
BMC Oral Health. 2021 Mar 6;21(1):101
pubmed: 33676486
Biochemistry. 1991 Apr 9;30(14):3351-6
pubmed: 1849422
J Biochem. 1983 Feb;93(2):495-502
pubmed: 6841349
Int J Biochem Cell Biol. 2006;38(10):1662-77
pubmed: 16730216
Autoimmune Dis. 2013;2013:548064
pubmed: 23533719
FASEB J. 2008 Nov;22(11):3805-12
pubmed: 18650243
Brain Res. 1997 Aug 15;765(2):183-8
pubmed: 9313890
Int J Mol Sci. 2022 Dec 13;23(24):
pubmed: 36555445
J Proteome Res. 2007 Apr;6(4):1371-7
pubmed: 17341109
Biochemistry. 1986 May 6;25(9):2387-92
pubmed: 3521730
Cell. 2021 Jun 10;184(12):3109-3124.e22
pubmed: 34004145
Acta Neuropathol. 2009 Oct;118(4):487-96
pubmed: 19547991
Clin Proteomics. 2009 Mar 1;5(1):52-68
pubmed: 20161393