Can RNA Affect Memory Modulation? Implications for PTSD Understanding and Treatment.
PTSD
RNA
memory
microRNA
transcription
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
17 Aug 2023
17 Aug 2023
Historique:
received:
19
07
2023
revised:
13
08
2023
accepted:
16
08
2023
medline:
28
8
2023
pubmed:
26
8
2023
entrez:
26
8
2023
Statut:
epublish
Résumé
Memories are a central aspect of our lives, but the mechanisms underlying their formation, consolidation, retrieval, and extinction remain poorly understood. In this review, we explore the molecular mechanisms of memory modulation and investigate the effects of RNA on these processes. Specifically, we examine the effects of time and location on gene expression alterations. We then discuss the potential for harnessing these alterations to modulate memories, particularly fear memories, to alleviate post-traumatic stress disorder (PTSD) symptoms. The current state of research suggests that transcriptional changes play a major role in memory modulation and targeting them through microRNAs may hold promise as a novel approach for treating memory-related disorders such as PTSD.
Identifiants
pubmed: 37629089
pii: ijms241612908
doi: 10.3390/ijms241612908
pmc: PMC10454422
pii:
doi:
Substances chimiques
MicroRNAs
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Références
Nature. 2009 Jul 23;460(7254):479-86
pubmed: 19536157
Proc Natl Acad Sci U S A. 1996 Nov 26;93(24):13453-9
pubmed: 8942956
Science. 1998 Jan 16;279(5349):338-41
pubmed: 9454331
Int J Mol Sci. 2021 May 13;22(10):
pubmed: 34068160
Neurobiol Stress. 2023 May 26;25:100545
pubmed: 37293561
Neuron. 2021 Sep 1;109(17):2649-2662
pubmed: 34242564
Neuropharmacology. 2012 Feb;62(2):705-14
pubmed: 22122881
J Neurosci. 2013 Jan 23;33(4):1734-40
pubmed: 23345246
Exp Neurol. 2022 Jun;352:114034
pubmed: 35259352
Philos Trans R Soc Lond B Biol Sci. 2013 Dec 02;369(1633):20130159
pubmed: 24298160
Transl Psychiatry. 2023 Feb 15;13(1):55
pubmed: 36792579
Transl Psychiatry. 2023 Jul 7;13(1):249
pubmed: 37419878
Cold Spring Harb Perspect Biol. 2015 Aug 03;7(8):a021766
pubmed: 26238360
Philos Trans R Soc Lond B Biol Sci. 2013 Dec 02;369(1633):20130288
pubmed: 24298167
Brain Behav Immun. 2019 Aug;80:904-908
pubmed: 31039430
Nucleic Acids Res. 2018 Jan 4;46(D1):D239-D245
pubmed: 29156006
Cell Rep. 2016 Feb 23;14(7):1698-1709
pubmed: 26876166
Curr Opin Neurobiol. 2001 Apr;11(2):180-7
pubmed: 11301237
Front Pharmacol. 2022 Mar 17;13:759626
pubmed: 35370690
J Neurosci. 2011 Jan 19;31(3):809-18
pubmed: 21248104
Nature. 1993 Jan 7;361(6407):31-9
pubmed: 8421494
Philos Trans R Soc Lond B Biol Sci. 2013 Dec 02;369(1633):20130141
pubmed: 24298143
Nature. 2020 Nov;587(7834):437-442
pubmed: 33177708
Neurobiol Learn Mem. 2022 Nov;195:107687
pubmed: 36283635
Cancer Cell. 2011 Jul 12;20(1):104-18
pubmed: 21741600
Trends Neurosci. 2005 Jan;28(1):12-9
pubmed: 15626492
Neuron. 2014 Oct 1;84(1):92-106
pubmed: 25277455
Science. 2010 Jun 4;328(5983):1288-90
pubmed: 20522777
Nat Neurosci. 2012 Sep;15(9):1255-64
pubmed: 22885849
Neuron. 2006 Apr 6;50(1):127-43
pubmed: 16600861
Neuroscience. 2018 Feb 1;370:4-13
pubmed: 28733211
Front Mol Neurosci. 2014 Nov 12;7:86
pubmed: 25429258
Nat Commun. 2019 Aug 9;10(1):3622
pubmed: 31399584
Science. 2000 Jan 14;287(5451):248-51
pubmed: 10634773
Neuron. 2014 Jan 22;81(2):294-305
pubmed: 24389009
Front Mol Neurosci. 2019 Dec 06;12:300
pubmed: 31866824
Neurosci Biobehav Rev. 2016 Dec;71:48-57
pubmed: 27590828
Cell. 1995 Dec 15;83(6):979-92
pubmed: 8521521
J Neurosci. 2016 Mar 23;36(12):3481-94
pubmed: 27013677
iScience. 2019 May 31;15:55-65
pubmed: 31030182
J Psychiatr Res. 2019 Nov;118:44-65
pubmed: 31493709
Nat Neurosci. 2010 May;13(5):630-4
pubmed: 20383136
Cell Mol Neurobiol. 2021 Mar;41(2):327-340
pubmed: 32333305
Learn Mem. 2019 Aug 15;26(9):307-317
pubmed: 31416904
Commun Biol. 2022 Jul 7;5(1):672
pubmed: 35798971
Neurosci Lett. 2017 May 10;649:139-146
pubmed: 28242325
J Neurosci. 2011 Apr 13;31(15):5562-73
pubmed: 21490196
Front Hum Neurosci. 2015 Feb 17;9:58
pubmed: 25774129
J Neurosci. 2005 Jan 12;25(2):502-6
pubmed: 15647495
Biol Psychiatry. 2018 May 15;83(10):849-865
pubmed: 29559087
Int J Mol Sci. 2021 Nov 09;22(22):
pubmed: 34830009
Neuron. 2021 Oct 20;109(20):3211-3227
pubmed: 34450024
Neuron. 1996 Jun;16(6):1137-45
pubmed: 8663990
Curr Top Behav Neurosci. 2018;38:23-46
pubmed: 29063484
Transl Psychiatry. 2017 Sep 12;7(9):e1231
pubmed: 28895942
Behav Res Ther. 2020 Dec;135:103752
pubmed: 33091680
Neurosci Biobehav Rev. 2021 Jun;125:592-607
pubmed: 33722616
Learn Mem. 2013 Jan 15;20(2):61-74
pubmed: 23322554
J Neurosci. 2017 Nov 8;37(45):10917-10931
pubmed: 28978667
Learn Mem. 2019 Aug 15;26(9):363-372
pubmed: 31416909
Psychopharmacology (Berl). 2019 Jan;236(1):163-182
pubmed: 30415278
Sci Rep. 2020 Aug 31;10(1):14331
pubmed: 32868857
Neuron. 1998 Nov;21(5):933-5
pubmed: 9856445
J Neurosci. 2009 Feb 4;29(5):1573-9
pubmed: 19193904
Science. 2011 Dec 23;334(6063):1669-75
pubmed: 22194569
Cold Spring Harb Perspect Biol. 2014 Dec 04;7(1):a021741
pubmed: 25475090
Transl Psychiatry. 2022 Jan 10;12(1):12
pubmed: 35013133
Psychopharmacology (Berl). 2009 Mar;202(4):569-78
pubmed: 18807247
PLoS Comput Biol. 2022 Oct 3;18(10):e1010543
pubmed: 36191056
J Neurosci. 2012 Dec 5;32(49):17857-68
pubmed: 23223304
Genes Brain Behav. 2012 Jul;11(5):503-12
pubmed: 22530815
BMJ. 2015 Nov 26;351:h6161
pubmed: 26611143
J Neurosci. 2011 Jun 15;31(24):8786-802
pubmed: 21677163
J Neuroinflammation. 2021 Jan 6;18(1):17
pubmed: 33407653
Cell. 1994 Oct 7;79(1):59-68
pubmed: 7923378
Neuron. 2003 Aug 14;39(4):655-69
pubmed: 12925279
J Neurosci. 2005 Feb 23;25(8):1935-42
pubmed: 15728833
Science. 2019 Jan 4;363(6422):
pubmed: 30545844