Importance of Pharmacogenetics and Drug-Drug Interactions in a Kidney Transplanted Patient.
drug–drug interaction
omeprazole
pharmacogenetics
polymorphisms
renal transplant
tacrolimus
Journal
Life (Basel, Switzerland)
ISSN: 2075-1729
Titre abrégé: Life (Basel)
Pays: Switzerland
ID NLM: 101580444
Informations de publication
Date de publication:
26 Jul 2023
26 Jul 2023
Historique:
received:
16
06
2023
revised:
20
07
2023
accepted:
24
07
2023
medline:
26
8
2023
pubmed:
26
8
2023
entrez:
26
8
2023
Statut:
epublish
Résumé
Tacrolimus (TAC) is a narrow-therapeutic-range immunosuppressant drug used after organ transplantation. A therapeutic failure is possible if drug levels are not within the therapeutic range after the first year of treatment. Pharmacogenetic variants and drug-drug interactions (DDIs) are involved. We describe a patient case of a young man (16 years old) with a renal transplant receiving therapy including TAC, mycophenolic acid (MFA), prednisone and omeprazole for prophylaxis of gastric and duodenal ulceration. The patient showed great fluctuation in TAC blood concentration/oral dose ratio, as well as pharmacotherapy adverse effects (AEs) and frequent diarrhea episodes. Additionally, decreased kidney function was found. A pharmacotherapeutic follow-up, including pharmacogenetic analysis, was carried out. The selection of the genes studied was based on the previous literature (
Identifiants
pubmed: 37629484
pii: life13081627
doi: 10.3390/life13081627
pmc: PMC10455535
pii:
doi:
Types de publication
Case Reports
Langues
eng
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