The Potential of the Nose-to-Brain Delivery of PACAP for the Treatment of Neuronal Disease.
apoptosis
cerebral plasticity
inflammation
intranasal delivery route
neuronal diseases
neuroprotection
pituitary adenylate cyclase-activating polypeptide
redox state
Journal
Pharmaceutics
ISSN: 1999-4923
Titre abrégé: Pharmaceutics
Pays: Switzerland
ID NLM: 101534003
Informations de publication
Date de publication:
28 Jul 2023
28 Jul 2023
Historique:
received:
12
06
2023
revised:
14
07
2023
accepted:
24
07
2023
medline:
26
8
2023
pubmed:
26
8
2023
entrez:
26
8
2023
Statut:
epublish
Résumé
Research on the neuroprotective effect of pituitary adenylate cyclase-activating polypeptide (PACAP) and its use as a therapeutic agent has grown over the past 30 years. Both in vitro and in vivo experiments have shown that PACAP exerts a strong neuroprotective effect in many central and peripheral neuronal diseases. Various delivery routes have been employed from intravenous (IV) injections to intracerebroventricular (ICV) administration, leading either to systemic or topical delivery of the peptide. Over the last decade, a growing interest in the use of intranasal (IN) administration of PACAP and other therapeutic agents has emerged as an alternative delivery route to target the brain. The aim of this review is to summarize the findings on the neuroprotective effect of PACAP and to discuss how the IN administration of PACAP could contribute to target the effects of this pleiotropic peptide.
Identifiants
pubmed: 37631246
pii: pharmaceutics15082032
doi: 10.3390/pharmaceutics15082032
pmc: PMC10459484
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
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