SARS-CoV-2 m-RNA Vaccine Response in Immunocompromised Patients: A Monocentric Study Comparing Cancer, People Living with HIV, Hematopoietic Stem Cell Transplant Patients and Lung Transplant Recipients.

SARS-CoV-2 immunodeficiency mRNA vaccines

Journal

Vaccines
ISSN: 2076-393X
Titre abrégé: Vaccines (Basel)
Pays: Switzerland
ID NLM: 101629355

Informations de publication

Date de publication:
26 Jul 2023
Historique:
received: 04 06 2023
revised: 12 07 2023
accepted: 19 07 2023
medline: 26 8 2023
pubmed: 26 8 2023
entrez: 26 8 2023
Statut: epublish

Résumé

Immunocompromised patients (ICPs) have a higher risk of developing severe forms of COVID-19 and experience a higher burden of complications and mortality than the general population. However, recent studies have suggested that the antibody response to SARS-CoV-2 mRNA vaccines could be highly variable among different ICPs. Using a collaborative, monocentric, prospective cohort study, we assessed anti-SARS-CoV-2 spike protein antibody titers following two and three doses of mRNA vaccines in four groups of ICPs (cancer [

Identifiants

pubmed: 37631852
pii: vaccines11081284
doi: 10.3390/vaccines11081284
pmc: PMC10459936
pii:
doi:

Types de publication

Journal Article

Langues

eng

Subventions

Organisme : University Hospitals Geneva Medical Center
ID : Research & Development Program

Références

Immun Inflamm Dis. 2022 Aug;10(8):e646
pubmed: 35894705
Eur J Med Res. 2022 Feb 12;27(1):23
pubmed: 35151362
Cancer Cell. 2021 Aug 9;39(8):1091-1098.e2
pubmed: 34214473
Vaccines (Basel). 2022 Aug 03;10(8):
pubmed: 36016131
Cell. 2020 Oct 1;183(1):158-168.e14
pubmed: 32979941
Front Immunol. 2022 Jun 01;13:906225
pubmed: 35720376
Cell. 2020 Jun 25;181(7):1489-1501.e15
pubmed: 32473127
NPJ Vaccines. 2022 Feb 28;7(1):28
pubmed: 35228535
JAMA Oncol. 2021 Aug 1;7(8):1133-1140
pubmed: 34047765
Ann Oncol. 2022 Dec;33(12):1333-1335
pubmed: 36116692
Bone Marrow Transplant. 2021 Dec;56(12):3094-3096
pubmed: 34584239
Science. 2022 Jan 07;375(6576):43-50
pubmed: 34812653
N Engl J Med. 2021 Feb 4;384(5):403-416
pubmed: 33378609
BMJ. 2022 Mar 2;376:e068632
pubmed: 35236664
J Heart Lung Transplant. 2021 Dec;40(12):1579-1588
pubmed: 34456108
AIDS. 2021 Nov 15;35(14):2399-2401
pubmed: 34261097
Blood. 2022 Jan 6;139(1):134-137
pubmed: 34818411
Nat Commun. 2022 Aug 22;13(1):4922
pubmed: 35995780
N Engl J Med. 2020 Dec 31;383(27):2603-2615
pubmed: 33301246
EClinicalMedicine. 2021 Nov;41:101158
pubmed: 34693234
Front Immunol. 2022 Feb 10;12:820126
pubmed: 35222357
J Infect. 2021 Mar;82(3):329-338
pubmed: 33549624
J Heart Lung Transplant. 2021 Aug;40(8):754-758
pubmed: 34120839
iScience. 2021 Dec 24;25(1):103699
pubmed: 34977496
Clin Microbiol Infect. 2022 Nov;28(11):1492-1498
pubmed: 35640840
JAMA. 2021 Jun 1;325(21):2204-2206
pubmed: 33950155
Cancer Cell. 2021 Aug 9;39(8):1081-1090.e2
pubmed: 34133951
Eur J Cancer. 2021 Sep;154:66-72
pubmed: 34243079

Auteurs

Natacha Bordry (N)

Department of Oncology, Geneva University Hospitals, University of Geneva and Swiss Cancer Center Leman, 1205 Geneva, Switzerland.

Anne-Claire Mamez (AC)

Department of Haematology, Geneva University Hospitals and Faculty of Medicine University of Geneva, 1205 Geneva, Switzerland.

Chiara Fedeli (C)

Department of Infectious Diseases, Geneva University Hospitals, University of Geneva, 1205 Geneva, Switzerland.

Chloé Cantero (C)

Department of Pneumology, Geneva University Hospitals, University of Geneva, 1205 Geneva, Switzerland.

Cyril Jaksic (C)

CRC & Division of Clinical Epidemiology, Department of Health and Community Medicine, University of Geneva and Geneva University Hospital, 1205 Geneva, Switzerland.

Pilar Ustero Alonso (PU)

Department of Infectious Diseases, Geneva University Hospitals, University of Geneva, 1205 Geneva, Switzerland.

Caroline Rayroux (C)

Department of Pneumology, Geneva University Hospitals, University of Geneva, 1205 Geneva, Switzerland.

Gregory Berra (G)

Department of Pneumology, Geneva University Hospitals, University of Geneva, 1205 Geneva, Switzerland.

Vera Portillo (V)

Department of Infectious Diseases, Geneva University Hospitals, University of Geneva, 1205 Geneva, Switzerland.

Maeva Puntel (M)

Department of Infectious Diseases, Geneva University Hospitals, University of Geneva, 1205 Geneva, Switzerland.

Sabine Yerly (S)

Laboratory of Virology, Division of Laboratory Medicine, Geneva University Hospitals & Faculty of Medicine, 1205 Geneva, Switzerland.

Sébastien Bugeia (S)

Department of Oncology, Geneva University Hospitals, University of Geneva and Swiss Cancer Center Leman, 1205 Geneva, Switzerland.

Garance Gutknecht (G)

Department of Oncology, Geneva University Hospitals, University of Geneva and Swiss Cancer Center Leman, 1205 Geneva, Switzerland.

Mariagrazia Di Marco (M)

Department of Oncology, Geneva University Hospitals, University of Geneva and Swiss Cancer Center Leman, 1205 Geneva, Switzerland.

Nicolas Mach (N)

Department of Oncology, Geneva University Hospitals, University of Geneva and Swiss Cancer Center Leman, 1205 Geneva, Switzerland.

Paola Marina Soccal (PM)

Department of Pneumology, Geneva University Hospitals, University of Geneva, 1205 Geneva, Switzerland.

Yves Chalandon (Y)

Department of Haematology, Geneva University Hospitals and Faculty of Medicine University of Geneva, 1205 Geneva, Switzerland.

Alexandra Calmy (A)

Department of Infectious Diseases, Geneva University Hospitals, University of Geneva, 1205 Geneva, Switzerland.

Alfredo Addeo (A)

Department of Oncology, Geneva University Hospitals, University of Geneva and Swiss Cancer Center Leman, 1205 Geneva, Switzerland.

Classifications MeSH