Protective Anti-HBs Antibodies and Response to a Booster Dose in Medical Students Vaccinated at Childhood.
HBV
booster dose
circadian rhythm
immunological memory
medical students
vaccination
Journal
Vaccines
ISSN: 2076-393X
Titre abrégé: Vaccines (Basel)
Pays: Switzerland
ID NLM: 101629355
Informations de publication
Date de publication:
05 Aug 2023
05 Aug 2023
Historique:
received:
07
07
2023
revised:
01
08
2023
accepted:
04
08
2023
medline:
26
8
2023
pubmed:
26
8
2023
entrez:
26
8
2023
Statut:
epublish
Résumé
The immune system in humans is regulated by the circadian rhythm. Published studies have reported that the time of vaccination is associated with the immune response to vaccine for some pathogens. Our study aimed to evaluate the association between time of dose administration of challenge HBV vaccine and seroconversion for anti-HBs in medical students vaccinated at birth who were found to be unprotected at pre-training screening. Humoral protection for HBV was assessed in 885 medical students vaccinated during childhood. In total, 359 (41.0%) of them showed anti-HBs titer < 10 UI/mL and received a challenge dose of HBV vaccine followed by post-vaccination screening 30-60 days later. The challenge dose elicited a protective immune response (anti-HBs IgG titer > 10 UI/mL) in 295 (83.8%) individuals. Seroconversion was significantly associated with female gender and time of vaccination after controlling for age group and nationality at logistic regression analysis. Students who received the booster dose in the morning had a higher response rate than those who received the vaccine in the afternoon (OR 1.93; 95% C.I. 1.047-3.56:
Identifiants
pubmed: 37631894
pii: vaccines11081326
doi: 10.3390/vaccines11081326
pmc: PMC10460060
pii:
doi:
Types de publication
Journal Article
Langues
eng
Références
Psychosom Med. 2003 Sep-Oct;65(5):831-5
pubmed: 14508028
Semin Immunopathol. 2022 Mar;44(2):193-207
pubmed: 34825270
Vaccines (Basel). 2021 Aug 25;9(9):
pubmed: 34579184
J Exp Med. 2016 Nov 14;213(12):2567-2574
pubmed: 27799619
Lancet. 2015 Oct 17;386(10003):1515-7
pubmed: 26231458
Vaccine. 2016 May 23;34(24):2679-85
pubmed: 27129425
Aging (Albany NY). 2020 Aug 3;12(15):15446-15461
pubmed: 32741775
New Microbiol. 2022 May 10;45(4):
pubmed: 36066216
Cell. 2021 Feb 18;184(4):861-880
pubmed: 33497610
Int J Environ Res Public Health. 2021 Dec 10;18(24):
pubmed: 34948662
J Clin Invest. 2020 Oct 1;130(10):5603-5617
pubmed: 32692732
J Immunol. 2011 Jul 1;187(1):283-90
pubmed: 21632713
Int J Infect Dis. 2021 May;106:376-381
pubmed: 33866000
Vaccine X. 2022 Jun 13;11:100178
pubmed: 35719326
Brain Behav Immun. 2012 Mar;26(3):407-13
pubmed: 22019350
J Community Health. 2022 Apr;47(2):211-225
pubmed: 34628568
Immunology. 2020 Dec;161(4):261-267
pubmed: 31820826
Clin Infect Dis. 2011 Jul 1;53(1):68-75
pubmed: 21653306
Front Immunol. 2018 Oct 08;9:2302
pubmed: 30349537
Int Immunol. 2010 Jan;22(1):25-34
pubmed: 19946015
Gerontology. 2010;56(6):574-80
pubmed: 20130392
Nat Rev Immunol. 2018 Jul;18(7):423-437
pubmed: 29662121
Immunity. 2017 Jan 17;46(1):120-132
pubmed: 28087238
Ann Gastroenterol. 2015 Apr-Jun;28(2):276-280
pubmed: 25830669
J Infect Dis. 2016 Jul 1;214(1):16-22
pubmed: 26802139
Vaccine X. 2023 Mar 21;14:100284
pubmed: 37063305
Nat Commun. 2023 Jan 30;14(1):476
pubmed: 36717561
Nat Immunol. 2001 Sep;2(9):777-80
pubmed: 11526384
J Exp Med. 2021 Feb 1;218(2):
pubmed: 33372990
Int J Behav Med. 2021 Feb;28(1):151-158
pubmed: 32236831
Clin Exp Vaccine Res. 2022 Jan;11(1):104-115
pubmed: 35223671
J Infect Dis. 2016 Jul 1;214(1):1-3
pubmed: 26802140
J Biol Rhythms. 2021 Dec;36(6):595-601
pubmed: 34696614
Sleep. 2012 Aug 01;35(8):1063-9
pubmed: 22851802
Int J Environ Res Public Health. 2022 Jul 20;19(14):
pubmed: 35886686
Nat Med. 1995 Dec;1(12):1279-83
pubmed: 7489409
Vaccine. 2011 Oct 13;29(44):7835-41
pubmed: 21816197
Int J Environ Res Public Health. 2019 Apr 29;16(9):
pubmed: 31035698
Lancet. 2005 Oct 15-21;366(9494):1379-84
pubmed: 16226616
J Biol Rhythms. 2022 Feb;37(1):124-129
pubmed: 34866459
Front Immunol. 2020 Jul 09;11:1457
pubmed: 32733482
Viruses. 2022 Aug 05;14(8):
pubmed: 36016350
Cell Res. 2021 Nov;31(11):1215-1217
pubmed: 34341489
Int J Environ Res Public Health. 2020 Oct 30;17(21):
pubmed: 33143150
Nat Rev Immunol. 2013 Mar;13(3):190-8
pubmed: 23391992
Psychophysiology. 2008 Jul;45(4):663-6
pubmed: 18346041
Blood. 2009 May 21;113(21):5134-43
pubmed: 19293427
J Med Virol. 2020 Oct;92(10):2050-2054
pubmed: 32383183