Elimination of Solanum nigrum ilarvirus 1 and Apple Hammerhead Viroid from Apple Cultivars Using Antivirals Ribavirin, Rimantadine, and Zidovudine.


Journal

Viruses
ISSN: 1999-4915
Titre abrégé: Viruses
Pays: Switzerland
ID NLM: 101509722

Informations de publication

Date de publication:
02 08 2023
Historique:
received: 21 06 2023
revised: 27 07 2023
accepted: 30 07 2023
medline: 28 8 2023
pubmed: 26 8 2023
entrez: 26 8 2023
Statut: epublish

Résumé

Apple hammerhead viroid (AHVd) was detected in the apple cultivar 'Šampion' and in mixed infection with Solanum nigrum ilarvirus 1 (SnIV-1) in the cultivars 'Selena' and 'Jonagored Supra', using a high-throughput sequencing method. Experiments were conducted to eliminate both pathogens in apples using meristem tip cultures in combination with the antivirotics ribavirin, rimantadine, and zidovudine. Elimination of both pathogens was verified by repeated RT-PCR and qRT-PCR assays after 7-11 months. Elimination of SnIV-1 from all cultivars was successful with each of the three antivirotics at concentrations of 20, 40, and 80 mg L

Identifiants

pubmed: 37632025
pii: v15081684
doi: 10.3390/v15081684
pmc: PMC10459016
pii:
doi:

Substances chimiques

Antiviral Agents 0
Rimantadine 0T2EF4JQTU
Ribavirin 49717AWG6K
Zidovudine 4B9XT59T7S

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Références

Annu Rev Virol. 2019 Sep 29;6(1):387-409
pubmed: 31283443
PLoS Pathog. 2014 Dec 11;10(12):e1004553
pubmed: 25503469
J Acquir Immune Defic Syndr (1988). 1989;2(5):441-7
pubmed: 2477523
Nature. 1986 Sep 25-Oct 1;323(6086):283
pubmed: 3463865
Plants (Basel). 2022 Feb 22;11(5):
pubmed: 35270052
Plant Dis. 1999 Aug;83(8):768-772
pubmed: 30845566
Pathogens. 2022 Oct 25;11(11):
pubmed: 36364981
Rev Med Virol. 2006 Jan-Feb;16(1):37-48
pubmed: 16287208
Antimicrob Agents Chemother. 1973 Feb;3(2):235-41
pubmed: 4208281
Rev Med Interne. 1988 Nov-Dec;9(5):554-8
pubmed: 3067304
Biochemistry. 2021 Aug 3;:
pubmed: 34342217
J Virol. 2022 Sep 28;96(18):e0064622
pubmed: 36040176
Virus Res. 2014 Jun 24;186:20-31
pubmed: 24361981
Science. 1972 Aug 25;177(4050):705-6
pubmed: 4340949
Virus Res. 2018 Apr 2;249:8-15
pubmed: 29510173
Front Microbiol. 2017 Jan 24;8:45
pubmed: 28174561
Heliyon. 2022 Nov 28;8(12):e11855
pubmed: 36466579
Virology. 2020 Jan 15;540:38-44
pubmed: 31734382
Viruses. 2022 Oct 25;14(11):
pubmed: 36366445
Agric Food Secur. 2022;11(1):21
pubmed: 35310134
PLoS One. 2020 Jan 13;15(1):e0227669
pubmed: 31929569

Auteurs

Jiří Sedlák (J)

Research and Breeding Institute of Pomology Holovousy, Ltd., Holovousy 129, 50801 Holovousy, Czech Republic.

Jaroslava Přibylová (J)

Czech Academy of Sciences, Biology Centre, Institute of Plant Molecular Biology, Branišovská 31, 37005 České Budějovice, Czech Republic.

Igor Koloňuk (I)

Czech Academy of Sciences, Biology Centre, Institute of Plant Molecular Biology, Branišovská 31, 37005 České Budějovice, Czech Republic.

Josef Špak (J)

Czech Academy of Sciences, Biology Centre, Institute of Plant Molecular Biology, Branišovská 31, 37005 České Budějovice, Czech Republic.

Ondřej Lenz (O)

Czech Academy of Sciences, Biology Centre, Institute of Plant Molecular Biology, Branišovská 31, 37005 České Budějovice, Czech Republic.

Matěj Semerák (M)

Research and Breeding Institute of Pomology Holovousy, Ltd., Holovousy 129, 50801 Holovousy, Czech Republic.

Articles similaires

Animals Swine Antiviral Agents Swine Diseases Coronavirus Infections
Humans Carcinoma, Hepatocellular Liver Neoplasms Aged United States
Deep Learning Fruit Malus Neural Networks, Computer Algorithms
Drug Repositioning Humans SARS-CoV-2 COVID-19 Drug Treatment Antiviral Agents

Classifications MeSH