The Burden of Epstein-Barr Virus (EBV) and Its Determinants among Adult HIV-Positive Individuals in Ethiopia.
DNA
Epstein–Barr virus
Ethiopia
HIV/AIDS
viral capsid antigen
Journal
Viruses
ISSN: 1999-4915
Titre abrégé: Viruses
Pays: Switzerland
ID NLM: 101509722
Informations de publication
Date de publication:
15 08 2023
15 08 2023
Historique:
received:
06
07
2023
revised:
28
07
2023
accepted:
07
08
2023
medline:
28
8
2023
pubmed:
26
8
2023
entrez:
26
8
2023
Statut:
epublish
Résumé
Epstein-Barr virus (EBV) is a well-known risk factor for the development of nasopharyngeal carcinoma, Hodgkin's lymphoma (HL), and Non-Hodgkin's lymphoma (NHL). People with HIV infection (PWH) are at increased risk for EBV-associated malignancies such as HL and NHL. Nevertheless, there are limited data on the burden of EBV among this population group in Ethiopia. Hence, this study aimed to determine the burden of EBV infection among adult HIV-positive individuals in Ethiopia and assess the determinants of EBV DNA positivity. We conducted a cross-sectional study at the Tikur Anbessa Specialised Hospital from March 2020 to March 2021. Two hundred and sixty individuals were enrolled in this study, including 179 HIV-positive and 81 HIV-negative individuals. A structured questionnaire was used to capture demographic and individual attributes. In addition, the clinical data of patients were also retrieved from clinical records. EBV viral capsid antigen (VCA) IgG antibody was measured by multiplex flow immunoassay, and EBV DNA levels were tested by quantitative real-time polymerase chain reaction (q-PCR) assays targeting the
Identifiants
pubmed: 37632085
pii: v15081743
doi: 10.3390/v15081743
pmc: PMC10458830
pii:
doi:
Substances chimiques
Antibodies, Viral
0
Immunoglobulin G
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIAID NIH HHS
ID : R01 AI141531
Pays : United States
Références
Trans R Soc Trop Med Hyg. 2017 Oct 1;111(10):464-471
pubmed: 29373741
Virusdisease. 2021 Mar;32(1):137-139
pubmed: 33969157
Biochim Biophys Acta. 2008 Mar;1782(3):127-50
pubmed: 18201576
HIV Med. 2013 Sep;14(8):481-90
pubmed: 23560682
Open AIDS J. 2016 Apr 08;10:34-48
pubmed: 27347270
Rev Assoc Med Bras (1992). 2014 May-Jun;60(3):262-9
pubmed: 25004273
Cancer. 2011 Mar 1;117(5):1089-96
pubmed: 20960504
AIDS. 2021 May 1;35(6):861-868
pubmed: 33749224
Biomed Pharmacother. 2022 Jan;145:112392
pubmed: 34781140
New Microbes New Infect. 2020 Jan 07;34:100641
pubmed: 32025310
Curr Top Microbiol Immunol. 2015;390(Pt 1):151-209
pubmed: 26424647
Epidemiol Infect. 2017 Aug;145(11):2330-2340
pubmed: 28578749
Front Microbiol. 2022 Feb 03;12:780887
pubmed: 35222296
Cancers (Basel). 2023 Jun 03;15(11):
pubmed: 37297008
Science. 2015 Jun 5;348(6239):aaa0698
pubmed: 26045439
J Clin Virol. 2008 Aug;42(4):433-6
pubmed: 18455472
Lancet Infect Dis. 2002 Jul;2(7):416-24
pubmed: 12127353
J Glob Oncol. 2018 Sep;4:1-11
pubmed: 30241262
Am J Trop Med Hyg. 2015 Feb;92(2):274-9
pubmed: 25385864
Clin Infect Dis. 2003 Nov 1;37(9):1244-9
pubmed: 14557970
Front Oncol. 2019 Aug 06;9:713
pubmed: 31448229
Cancer Lett. 2011 Jun 28;305(2):163-74
pubmed: 21493001
Front Oncol. 2022 Mar 07;12:812224
pubmed: 35340265
N Engl J Med. 1998 Mar 26;338(13):853-60
pubmed: 9516219
Indian J Med Microbiol. 2014 Jul-Sep;32(3):261-9
pubmed: 25008818
J Infect Dis. 2012 Jan 1;205(1):106-10
pubmed: 22075766
Curr HIV/AIDS Rep. 2015 Sep;12(3):362-72
pubmed: 26152660
Acta Med Port. 2011 Sep-Oct;24(5):707-12
pubmed: 22525621
J Med Virol. 2006 Dec;78(12):1635-42
pubmed: 17063511
Cancer Epidemiol. 2018 Apr;53:93-98
pubmed: 29414637
N Engl J Med. 1995 Jan 5;332(1):12-8
pubmed: 7990860
AIDS Res Hum Retroviruses. 1992 Nov;8(11):1869-74
pubmed: 1336962
Mediterr J Hematol Infect Dis. 2009 Dec 29;1(2):e2009032
pubmed: 21416008
PLoS One. 2014 Jun 10;9(6):e99243
pubmed: 24914671
Pathogens. 2020 Mar 18;9(3):
pubmed: 32197545
BMC Infect Dis. 2008 Aug 18;8:111
pubmed: 18706107
N Engl J Med. 2010 May 27;362(21):1993-2000
pubmed: 20505178
Haematologica. 2010 Oct;95(10):1769-77
pubmed: 20421267
Front Oncol. 2020 Sep 30;10:1723
pubmed: 33102204
PLoS One. 2017 Dec 11;12(12):e0189033
pubmed: 29228016
Clin Exp Immunol. 2007 Dec;150(3):442-50
pubmed: 17956580
Oral Dis. 2001 Jan;7(1):34-40
pubmed: 11354920