Sensitization patterns to cat molecular allergens in subjects with allergic sensitization to cat dander.
Fel d 1
allergic sensitization
cat allergy
lipocalins
molecular allergens
Journal
Clinical and translational allergy
ISSN: 2045-7022
Titre abrégé: Clin Transl Allergy
Pays: England
ID NLM: 101576043
Informations de publication
Date de publication:
Aug 2023
Aug 2023
Historique:
revised:
21
07
2023
received:
13
04
2023
accepted:
31
07
2023
medline:
26
8
2023
pubmed:
26
8
2023
entrez:
26
8
2023
Statut:
ppublish
Résumé
The use of molecular allergology has increasingly become common in the diagnosis and management of allergic diseases. However, there is still a lack of data on cat molecular allergens in adults. Therefore, we aimed to uncover the sensitization patterns to cat molecular allergens. Participants were recruited from the West Asthma Sweden Study, a population-based study enriched with asthma subjects aged 16-75 years. Of 1872, 361 individuals were positive for cat dander immunoglobulin E and were further analysed for cat molecular allergens (Fel d 1/2/4/7). Sensitization patterns were classified as monosensitization, polysensitization, and concomitant sensitization, and were related to demographic and clinical measurements. Among cat-sensitized subjects, 84.2% were sensitized to secretoglobin, while 42.4% were sensitized to lipocalins. Nearly half of the subjects were monosensitized to Fel d 1. Polysensitization was observed in 20.2%, and concomitant sensitization to protein families was seen in 7.2%. Asthma prevalence, cat exposure, and rural living were associated with poly- and concomitant sensitization to protein families. Concomitant sensitization to single allergens was more common in those with asthma than in those without, while concomitant sensitization to both Fel d 1 and Fel d 4 was the most common pattern in individuals with asthma. Sensitization patterns also differed according to cat ownership and the degree of urbanization. Sensitization to molecular allergens was observed in 90.9% of cat-sensitized subjects and showed variations across participants' background characteristics and the presence of asthma. Identification of sensitization patterns to cat allergens might provide better characterization of cat-allergic subjects.
Sections du résumé
BACKGROUND
BACKGROUND
The use of molecular allergology has increasingly become common in the diagnosis and management of allergic diseases. However, there is still a lack of data on cat molecular allergens in adults. Therefore, we aimed to uncover the sensitization patterns to cat molecular allergens.
METHODS
METHODS
Participants were recruited from the West Asthma Sweden Study, a population-based study enriched with asthma subjects aged 16-75 years. Of 1872, 361 individuals were positive for cat dander immunoglobulin E and were further analysed for cat molecular allergens (Fel d 1/2/4/7). Sensitization patterns were classified as monosensitization, polysensitization, and concomitant sensitization, and were related to demographic and clinical measurements.
RESULTS
RESULTS
Among cat-sensitized subjects, 84.2% were sensitized to secretoglobin, while 42.4% were sensitized to lipocalins. Nearly half of the subjects were monosensitized to Fel d 1. Polysensitization was observed in 20.2%, and concomitant sensitization to protein families was seen in 7.2%. Asthma prevalence, cat exposure, and rural living were associated with poly- and concomitant sensitization to protein families. Concomitant sensitization to single allergens was more common in those with asthma than in those without, while concomitant sensitization to both Fel d 1 and Fel d 4 was the most common pattern in individuals with asthma. Sensitization patterns also differed according to cat ownership and the degree of urbanization.
CONCLUSION
CONCLUSIONS
Sensitization to molecular allergens was observed in 90.9% of cat-sensitized subjects and showed variations across participants' background characteristics and the presence of asthma. Identification of sensitization patterns to cat allergens might provide better characterization of cat-allergic subjects.
Identifiants
pubmed: 37632243
doi: 10.1002/clt2.12294
pmc: PMC10422092
doi:
Types de publication
Journal Article
Langues
eng
Pagination
e12294Subventions
Organisme : VBG Group Herman Krefting Foundation for Asthma and Allergy Research, Sweden
Organisme : Swedish Asthma and Allergy Foundation
ID : F2021-0041
Organisme : ALF agreement (Västra Götaland)
ID : ALFGBG-966075
Organisme : Wallenberg Centre for Molecular and Translational Medicine; Knut and Alice Wallenberg Foundation
Organisme : Thermo Fisher Scientific
Organisme : Swedish Heart-Lung Foundation
ID : 20180525
Organisme : Swedish Heart-Lung Foundation
ID : 20200832
Organisme : Swedish Heart-Lung Foundation
ID : 20210284
Organisme : Swedish Heart-Lung Foundation
ID : 20220724
Organisme : Swedish Research Council
ID : 2019-00247
Informations de copyright
© 2023 The Authors. Clinical and Translational Allergy published by John Wiley & Sons Ltd on behalf of European Academy of Allergy and Clinical Immunology.
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