Targeting the Gut Microbiota in Kidney Disease: The Future in Renal Nutrition and Metabolism.
Gut microbiome
chronic kidney disease
diet
end-stage kidney disease
gastrointestinal
gut microbiota
kidney failure
nutrition
prebiotics
probiotics
synbiotics
Journal
Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation
ISSN: 1532-8503
Titre abrégé: J Ren Nutr
Pays: United States
ID NLM: 9112938
Informations de publication
Date de publication:
Nov 2023
Nov 2023
Historique:
received:
01
07
2022
revised:
05
10
2022
accepted:
10
12
2022
medline:
27
11
2023
pubmed:
27
8
2023
entrez:
26
8
2023
Statut:
ppublish
Résumé
There is increasing interest in the therapeutic potential of manipulating the gut microbiome of patients with chronic kidney disease (CKD). This is because there is a substantial deviation from a balanced gut microbiota profile in CKD, with many deleterious downstream effects. Nutritional interventions such as plant-based diets with reduced animal protein intake and the use of probiotics, prebiotics, and synbiotics may alter the microbiome. This article aims to briefly describe what is known about the gut microbiome in patients with CKD, factors contributing to gut dysbiosis, and outline important evidence gaps. Future potential therapies, including restoring the microbiota with food and microbiota-based and metabolomic-based therapies, are also discussed.
Identifiants
pubmed: 37632511
pii: S1051-2276(22)00213-8
doi: 10.1053/j.jrn.2022.12.004
pii:
doi:
Substances chimiques
Prebiotics
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
S30-S39Subventions
Organisme : NCATS NIH HHS
ID : UL1 TR002529
Pays : United States
Informations de copyright
Copyright © 2023 National Kidney Foundation, Inc. Published by Elsevier Inc. All rights reserved.