Enteric neuro-immune interactions in intestinal health and disease.
Enteric Nervous System
Intestinal Disease
Intestinal Homeostasis
Intestinal Immunity
Neuro-immune Interactions
Journal
Seminars in immunology
ISSN: 1096-3618
Titre abrégé: Semin Immunol
Pays: England
ID NLM: 9009458
Informations de publication
Date de publication:
Nov 2023
Nov 2023
Historique:
received:
30
09
2022
revised:
19
07
2023
accepted:
11
08
2023
pubmed:
27
8
2023
medline:
27
8
2023
entrez:
26
8
2023
Statut:
ppublish
Résumé
The enteric nervous system is an autonomous neuronal circuit that regulates many processes far beyond the peristalsis in the gastro-intestinal tract. This circuit, consisting of enteric neurons and enteric glial cells, can engage in many intercellular interactions shaping the homeostatic microenvironment in the gut. Perhaps the most well documented interactions taking place, are the intestinal neuro-immune interactions which are essential for the fine-tuning of oral tolerance. In the context of intestinal disease, compelling evidence demonstrates both protective and detrimental roles for this bidirectional neuro-immune signaling. This review discusses the different immune cell types that are recognized to engage in neuronal crosstalk during intestinal health and disease. Highlighting the molecular pathways involved in the neuro-immune interactions might inspire novel strategies to target intestinal disease.
Identifiants
pubmed: 37632991
pii: S1044-5323(23)00110-0
doi: 10.1016/j.smim.2023.101819
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
101819Informations de copyright
Copyright © 2023 Elsevier Ltd. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest None.