Modeling and countering the effects of cosmic radiation using bioengineered human tissues.
Bone marrow
Heart
Organs on chip
Radiation
Space health
Tissue engineering
Journal
Biomaterials
ISSN: 1878-5905
Titre abrégé: Biomaterials
Pays: Netherlands
ID NLM: 8100316
Informations de publication
Date de publication:
10 2023
10 2023
Historique:
received:
16
02
2023
revised:
31
07
2023
accepted:
03
08
2023
pmc-release:
01
10
2024
medline:
6
9
2023
pubmed:
27
8
2023
entrez:
26
8
2023
Statut:
ppublish
Résumé
Cosmic radiation is the most serious risk that will be encountered during the planned missions to the Moon and Mars. There is a compelling need to understand the effects, safety thresholds, and mechanisms of radiation damage in human tissues, in order to develop measures for radiation protection during extended space travel. As animal models fail to recapitulate the molecular changes in astronauts, engineered human tissues and "organs-on-chips" are valuable tools for studying effects of radiation in vitro. We have developed a bioengineered tissue platform for studying radiation damage in individualized settings. To demonstrate its utility, we determined the effects of radiation using engineered models of two human tissues known to be radiosensitive: engineered cardiac tissues (eCT, a target of chronic radiation damage) and engineered bone marrow (eBM, a target of acute radiation damage). We report the effects of high-dose neutrons, a proxy for simulated galactic cosmic rays, on the expression of key genes implicated in tissue responses to ionizing radiation, phenotypic and functional changes in both tissues, and proof-of-principle application of radioprotective agents. We further determined the extent of inflammatory, oxidative stress, and matrix remodeling gene expression changes, and found that these changes were associated with an early hypertrophic phenotype in eCT and myeloid skewing in eBM. We propose that individualized models of human tissues have potential to provide insights into the effects and mechanisms of radiation during deep-space missions and allow testing of radioprotective measures.
Identifiants
pubmed: 37633022
pii: S0142-9612(23)00275-2
doi: 10.1016/j.biomaterials.2023.122267
pmc: PMC10528250
mid: NIHMS1927523
pii:
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
122267Subventions
Organisme : NIH HHS
ID : S10 OD025190
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA249799
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL076485
Pays : United States
Organisme : NCI NIH HHS
ID : K99 CA267168
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA013696
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL120046
Pays : United States
Organisme : NIBIB NIH HHS
ID : P41 EB027062
Pays : United States
Organisme : NIAID NIH HHS
ID : U19 AI067773
Pays : United States
Organisme : NIH HHS
ID : S10 OD026845
Pays : United States
Organisme : NCI NIH HHS
ID : F31 CA275733
Pays : United States
Informations de copyright
Copyright © 2023 Elsevier Ltd. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of competing interest The authors do not have any personal or financial relationships that would constitute conflict of interest.
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