The development and characterization of in vivo-like three-dimensional models of bronchial epithelial cell lines.

Bronchial epithelial cells Cystic fibrosis Differentiation Organotypic Rotating wall vessel bioreactor Three-dimensional cell culture models

Journal

European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences
ISSN: 1879-0720
Titre abrégé: Eur J Pharm Sci
Pays: Netherlands
ID NLM: 9317982

Informations de publication

Date de publication:
01 Nov 2023
Historique:
received: 06 06 2023
revised: 16 08 2023
accepted: 18 08 2023
pubmed: 27 8 2023
medline: 27 8 2023
entrez: 26 8 2023
Statut: ppublish

Résumé

In vitro models of differentiated respiratory epithelium that allow high-throughput screening are an important tool to explore new therapeutics for chronic respiratory diseases. In the present study, we developed in vivo-like three-dimensional (3-D) models of bronchial epithelial cell lines that are commonly used to study chronic lung disease (16HBE14o

Identifiants

pubmed: 37633341
pii: S0928-0987(23)00197-5
doi: 10.1016/j.ejps.2023.106567
pii:
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

106567

Informations de copyright

Copyright © 2023. Published by Elsevier B.V.

Auteurs

Sara Van den Bossche (S)

Laboratory of Pharmaceutical Microbiology, Ghent University, Ottergemsesteenweg 460, Ghent 9000, Belgium.

Lisa Ostyn (L)

Laboratory of Pharmaceutical Microbiology, Ghent University, Ottergemsesteenweg 460, Ghent 9000, Belgium.

Valerie Vandendriessche (V)

Laboratory of Pharmaceutical Microbiology, Ghent University, Ottergemsesteenweg 460, Ghent 9000, Belgium.

Charlotte Rigauts (C)

Laboratory of Pharmaceutical Microbiology, Ghent University, Ottergemsesteenweg 460, Ghent 9000, Belgium.

Herlinde De Keersmaecker (H)

Centre of Advanced Light Microscopy, Ghent University, Ottergemsesteenweg 460, Ghent 9000, Belgium; Laboratory of General Biochemistry and Physical Pharmacy, Faculty of Pharmacy, Ghent University, Ottergemsesteenweg 460, Ghent 9000, Belgium.

Cheryl A Nickerson (CA)

School of Life Sciences, Biodesign Center for Fundamental and Applied Microbiomics, Biodesign Institute, Arizona State University, 727 E. Tyler Street, Tempe, Arizona 85281, USA.

Aurélie Crabbé (A)

Laboratory of Pharmaceutical Microbiology, Ghent University, Ottergemsesteenweg 460, Ghent 9000, Belgium. Electronic address: aurelie.crabbe@UGent.be.

Classifications MeSH