Inflammasome assembly in neurodegenerative diseases.
AIM2
Alzheimer’s disease
NLRC4
NLRP1
NLRP3
Parkinson’s disease
amyotrophic lateral sclerosis
frontotemporal dementia
multiple sclerosis
Journal
Trends in neurosciences
ISSN: 1878-108X
Titre abrégé: Trends Neurosci
Pays: England
ID NLM: 7808616
Informations de publication
Date de publication:
10 2023
10 2023
Historique:
received:
30
04
2023
revised:
26
06
2023
accepted:
31
07
2023
pmc-release:
01
10
2024
medline:
22
9
2023
pubmed:
27
8
2023
entrez:
26
8
2023
Statut:
ppublish
Résumé
Neurodegenerative disorders are characterized by the progressive dysfunction and death of selectively vulnerable neuronal populations, often associated with the accumulation of aggregated host proteins. Sustained brain inflammation and hyperactivation of inflammasome complexes have been increasingly demonstrated to contribute to neurodegenerative disease progression. Here, we review molecular mechanisms leading to inflammasome assembly in neurodegeneration. We focus primarily on four degenerative brain disorders in which inflammasome hyperactivation has been well documented: Alzheimer's disease (AD), Parkinson's disease (PD), multiple sclerosis (MS), and the spectrum of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). We discuss shared and divergent principles of inflammasome assembly across these disorders, and underscore the differences between neurodegeneration-associated inflammasome activation pathways and their peripheral-immune counterparts. We examine how aberrant assembly of inflammasome complexes may amplify pathology in neurodegeneration, including misfolded protein aggregation, and highlight prospects for neurotherapeutic interventions based on targeting inflammasome pathways.
Identifiants
pubmed: 37633753
pii: S0166-2236(23)00174-1
doi: 10.1016/j.tins.2023.07.009
pmc: PMC10530301
mid: NIHMS1922690
pii:
doi:
Substances chimiques
Inflammasomes
0
Types de publication
Journal Article
Review
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
814-831Subventions
Organisme : NIA NIH HHS
ID : R00 AG066862
Pays : United States
Informations de copyright
Copyright © 2023 Elsevier Ltd. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of interests The authors declare no competing interests.
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