Lysosomal glucose sensing and glycophagy in metabolism.
autophagy
carbohydrate sensing
glycogen
nutrient sensing
Journal
Trends in endocrinology and metabolism: TEM
ISSN: 1879-3061
Titre abrégé: Trends Endocrinol Metab
Pays: United States
ID NLM: 9001516
Informations de publication
Date de publication:
11 2023
11 2023
Historique:
received:
18
04
2023
revised:
27
07
2023
accepted:
28
07
2023
pmc-release:
01
11
2024
medline:
26
10
2023
pubmed:
27
8
2023
entrez:
26
8
2023
Statut:
ppublish
Résumé
Lysosomes are cellular organelles that function to catabolize both extra- and intracellular cargo, act as a platform for nutrient sensing, and represent a core signaling node integrating bioenergetic cues to changes in cellular metabolism. Although lysosomal amino acid and lipid sensing in metabolism has been well characterized, lysosomal glucose sensing and the role of lysosomes in glucose metabolism is unrefined. This review will highlight the role of the lysosome in glucose metabolism with a focus on lysosomal glucose and glycogen sensing, glycophagy, and lysosomal glucose transport and how these processes impact autophagy and energy metabolism. Additionally, the role of lysosomal glucose metabolism in genetic and metabolic diseases will be briefly discussed.
Identifiants
pubmed: 37633800
pii: S1043-2760(23)00152-2
doi: 10.1016/j.tem.2023.07.008
pmc: PMC10592240
mid: NIHMS1921940
pii:
doi:
Substances chimiques
Glycogen
9005-79-2
Glucose
IY9XDZ35W2
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
764-777Subventions
Organisme : NIAID NIH HHS
ID : R03 AI151920
Pays : United States
Organisme : NIDDK NIH HHS
ID : K01 DK125258
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK123183
Pays : United States
Organisme : NIDDK NIH HHS
ID : F32 DK109556
Pays : United States
Organisme : NIGMS NIH HHS
ID : P20 GM135002
Pays : United States
Organisme : NIDDK NIH HHS
ID : L30 DK110338
Pays : United States
Informations de copyright
Copyright © 2023 Elsevier Ltd. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of interests No interests are declared.
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