Overview of sexual dysfunction in patients with cancer.
Cancer survivors
Oncological treatment
Quality of life
Sexual dysfunction
Journal
Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico
ISSN: 1699-3055
Titre abrégé: Clin Transl Oncol
Pays: Italy
ID NLM: 101247119
Informations de publication
Date de publication:
Dec 2023
Dec 2023
Historique:
received:
10
08
2023
accepted:
11
08
2023
medline:
27
10
2023
pubmed:
27
8
2023
entrez:
26
8
2023
Statut:
ppublish
Résumé
Among survivor's patients with cancer, sexual dysfunction (SD) is a common treatment-related disturbance that significantly affects their quality of life. The disorder can be a short-term effect, but frequently it can be permanent and patients often do not receive adequate support to overcome the problem. The characteristics of SD may differ depending on the type of neoplasm and oncological treatment. The most common long-term effects are those related to treatment-induced menopause, ablative oncologic surgery, and altered gonadal function. Breast, prostate, and gynecologic cancers are the tumors most commonly associated with disturbances in sexual health, although there is evidence of SD in patients with other types of neoplasms. It is necessary for the healthcare team caring for oncological patients to be aware of the characteristics of sexual dysfunction in this population. This will make it possible to offer patients a comprehensive and personalized approach to improve their quality of life.
Identifiants
pubmed: 37633856
doi: 10.1007/s12094-023-03311-5
pii: 10.1007/s12094-023-03311-5
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
3369-3377Informations de copyright
© 2023. The Author(s), under exclusive licence to Federación de Sociedades Españolas de Oncología (FESEO).
Références
Krouwel EM, Albers LF, Nicolai MPJ, Putter H, Osanto S, Pelger RCM, et al. Discussing sexual health in the medical oncologist’s practice: exploring current practice and challenges. J Cancer Educ. 2020;35(6):1072–88.
pubmed: 31209770
doi: 10.1007/s13187-019-01559-6
Carter J, Lacchetti C, Andersen BL, Barton DL, Bolte S, Damast S, et al. Journal of clinical oncology. J Clin Oncol. 2017;36:492–511. https://doi.org/10.1200/JCO.2017 .
doi: 10.1200/JCO.2017
pubmed: 29227723
Walker LM, Wiebe E, Turner J, Driga A, Andrews-Lepine E, Ayume A, et al. The oncology and sexuality, intimacy, and survivorship program model: an integrated, multi-disciplinary model of sexual health care within oncology. J Cancer Educ. 2021;36(2):377–85.
pubmed: 31797198
doi: 10.1007/s13187-019-01641-z
Ferlay J, Colombet M, Soerjomataram I, Mathers C, Parkin DM, Piñeros M, et al. Estimating the global cancer incidence and mortality in 2018: GLOBOCAN sources and methods. Int J Cancer. 2019;144(8):1941–53.
pubmed: 30350310
doi: 10.1002/ijc.31937
Sánchez F, Pérez Conchillo M, Borrás Valls JJ, Gómez Llorens O, Aznar Vicentee J. Caballero Martín de las Mulas A. Diseño y validación del cuestionario de función sexual de la Mujer (FSM). Aten Primaria. 2004;34(6):286–94.
pubmed: 15491520
pmcid: 7669196
doi: 10.1016/S0212-6567(04)79497-4
Bober SL, Varela VS. Sexuality in adult cancer survivors: challenges and intervention. J Clin Oncol. 2012;30(30):3712–9.
pubmed: 23008322
doi: 10.1200/JCO.2012.41.7915
Figueroa-Martín L, Duarte-Clíments G, Sánchez-Gómez MB, Ruyman B-B. Abordaje de la sexualidad en atención primaria: ¿qué valorar? Ene. 2015. https://doi.org/10.4321/S1988-348X2015000200006 .
doi: 10.4321/S1988-348X2015000200006
Lewis RW, Fugl-Meyer KS, Bosch R, Fugl-Meyer AR, Laumann EO, Lizza E, et al. Epidemiology/risk factors of sexual dysfunction. J Sex Med. 2004;1(1):35–9.
pubmed: 16422981
doi: 10.1111/j.1743-6109.2004.10106.x
Cakar B, Karaca B, Uslu R. Sexual dysfunction in cancer patients: a review. J Buon. 2013;18(4):818–23.
pubmed: 24344003
McCabe MP, Sharlip ID, Lewis R, Atalla E, Balon R, Fisher AD, et al. Incidence and prevalence of sexual dysfunction in women and men: a consensus statement from the fourth international consultation on sexual medicine 2015. J Sex Med. 2016;13(2):144–52.
pubmed: 26953829
doi: 10.1016/j.jsxm.2015.12.034
Salter CA, Mulhall JP. Oncosexology. Urol Clin North Am. 2021;48(4):591–602.
pubmed: 34602178
doi: 10.1016/j.ucl.2021.07.001
Lovelace DL, McDaniel LR, Golden D. Long-term effects of breast cancer surgery, treatment, and survivor care. J Midwifery Womens Health. 2019;64(6):713–24.
pubmed: 31322834
doi: 10.1111/jmwh.13012
Stulz A, Lamore K, Montalescot L, Favez N, Flahault C. Sexual health in colon cancer patients: a systematic review. Psychooncology. 2020;29(7):1095–104.
pubmed: 32281129
doi: 10.1002/pon.5391
Tramacere F, Lancellotta V, Casà C, Fionda B, Cornacchione P, Mazzarella C, et al. Assessment of sexual dysfunction in cervical cancer patients after different treatment modality: a systematic review. Medicina. 2022;58(9):1223.
pubmed: 36143900
pmcid: 9504584
doi: 10.3390/medicina58091223
Celentano V, Cohen R, Warusavitarne J, Faiz O, Chand M. Sexual dysfunction following rectal cancer surgery. Int J Colorectal Dis. 2017;32(11):1523–30.
pubmed: 28497404
doi: 10.1007/s00384-017-2826-4
Jackson SE, Wardle J, Steptoe A, Fisher A. Sexuality after a cancer diagnosis: a population-based study. Cancer. 2016;122(24):3883–91.
pubmed: 27531631
doi: 10.1002/cncr.30263
Wallington DG, Holliday EB. Preparing patients for sexual dysfunction after radiation for anorectal cancers: a systematic review. Pract Radiat Oncol. 2021;11(3):193–201.
pubmed: 32777386
doi: 10.1016/j.prro.2020.07.007
Sánchez-Sánchez F, Ferrer-Casanova C, Ponce-Buj B, Sipán-Sarrión Y, Jurado-López AR, San Martin-Blanco C, et al. Design and validation of a male sexual function questionnaire. SEMERGEN. 2020;46(7):441–7.
pubmed: 32089399
doi: 10.1016/j.semerg.2019.12.005
Ospina Serrano AV, Maximiano C, de Sanchez CBI, Torrente M, Mendez M, Sanchez JC, et al. Sexual dysfunction in patients with cancer: Results from the CLARIFY project. J Clin Oncol. 2023;41(16):12094–12094.
doi: 10.1200/JCO.2023.41.16_suppl.12094
Shifren JL, Monz BU, Russo PA, Segreti A, Johannes CB. Sexual problems and distress in United States women. Obstet Gynecol. 2008;112(5):970–8.
pubmed: 18978095
doi: 10.1097/AOG.0b013e3181898cdb
Basson R. Sexual desire and arousal disorders in women. N Engl J Med. 2006;354(14):1497–506.
pubmed: 16598046
doi: 10.1056/NEJMcp050154
Sousa Rodrigues Guedes T, Barbosa Otoni Gonçalves Guedes M, de Castro Santana R, Costa da Silva JF, Almeida Gomes Dantas A, Ochandorena-Acha M, et al. Sexual Dysfunction in Women with Cancer: A Systematic Review of Longitudinal Studies. Int J Environ Res Public Health. 2022; 19(19).
Rodrigues-Machado N, Quintana MJ, Gómez-Gómez R, Bonfill-Cosp X. Sexual function in women with breast cancer: an evidence map of observational studies. Int J Environ Res Public Health. 2022;19(21):13976.
pubmed: 36360854
pmcid: 9654538
doi: 10.3390/ijerph192113976
Jing L, Zhang C, Li W, Jin F, Wang A. Incidence and severity of sexual dysfunction among women with breast cancer: a meta-analysis based on female sexual function index. Support Care Cancer. 2019;27(4):1171–80.
pubmed: 30712099
doi: 10.1007/s00520-019-04667-7
Clayton AH, Valladares Juarez EM. Female sexual dysfunction. Med Clin North Am. 2019;103(4):681–98.
pubmed: 31078200
doi: 10.1016/j.mcna.2019.02.008
Gozzi E, La Manna AR, Rossi L, Colonna M, Ulgiati MA, Romagnoli L, et al. What hides beneath the scar: sexuality and breast cancer what women don’t say: a single-center study. Clin Ter. 2022;173(4):342–6.
pubmed: 35857051
Fingeret MC, Teo I, Epner DE. Managing body image difficulties of adult cancer patients: Lessons from available research. Cancer. 2014;120(5):633–41.
pubmed: 24895287
doi: 10.1002/cncr.28469
Dusetzina SB, Alexander GC, Freedman RA, Huskamp HA, Keating NL. Trends in co-prescribing of antidepressants and tamoxifen among women with breast cancer, 2004–2010. Breast Cancer Res Treat. 2013;137(1):285–96.
pubmed: 23149465
doi: 10.1007/s10549-012-2330-z
Bober SL, Reese JB, Barbera L, Bradford A, Carpenter KM, Goldfarb S, et al. How to ask and what to do. Curr Opin Support Palliat Care. 2016;10(1):44–54.
pubmed: 26716390
pmcid: 4984532
doi: 10.1097/SPC.0000000000000186
Sarna L. Women with lung cancer: impact on quality of life. Qual Life Res. 1993;2(1):13–22.
pubmed: 8387854
doi: 10.1007/BF00642885
Duma N, Acharya R, Wei Z, Seaborne L, Heisler C, Fidler MJ, et al. MA14.04 sexual health assessment in women with lung cancer (SHAWL) study. J Thorac Oncol. 2022;17(9):93–4.
doi: 10.1016/j.jtho.2022.07.156
Basson R. Women’s sexual dysfunction: revised and expanded definitions. Can Med Assoc J. 2005;172(10):1327–33.
doi: 10.1503/cmaj.1020174
Tiefer L. A new view of women’s sexual problems: why new? Why now? J Sex Res. 2001;38(2):89–96.
doi: 10.1080/00224490109552075
Cella D, Yount S, Rothrock N, Gershon R, Cook K, Reeve B, et al. The patient-reported outcomes measurement information system (PROMIS). Med Care. 2007;45(5):S3-11.
pubmed: 17443116
pmcid: 2829758
doi: 10.1097/01.mlr.0000258615.42478.55
Huyghe E, Sui D, Odensky E, Schover LR. Needs assessment survey to justify establishing a reproductive health clinic at a comprehensive cancer center. J Sex Med. 2009;6(1):149–63.
pubmed: 18823323
doi: 10.1111/j.1743-6109.2008.01005.x
Rosen CBJHSLR. The female sexual function index (FSFI): a multidimensional self-report instrument for the assessment of female sexual function. J Sex Marital Ther. 2000;26(2):191–208.
pubmed: 10782451
doi: 10.1080/009262300278597
Flynn KE, Lin L, Cyranowski JM, Reeve BB, Reese JB, Jeffery DD, et al. Development of the NIH PROMIS
pubmed: 23387911
pmcid: 3729213
doi: 10.1111/j.1743-6109.2012.02995.x
Maiorino MI, Chiodini P, Bellastella G, Giugliano D, Esposito K. Sexual dysfunction in women with cancer: a systematic review with meta-analysis of studies using the female sexual function index. Endocrine. 2016;54(2):329–41.
pubmed: 26643312
doi: 10.1007/s12020-015-0812-6
Johannes CB, Araujo AB, Feldman HA, Derby CA, Kleinman KP, McKinlay JB. Incidence of erectile dysfunction in men 40 to 69 years old: longitudinal results from the Massachusetts male aging study. J Urol. 2000;163(2):460–3.
pubmed: 10647654
doi: 10.1016/S0022-5347(05)67900-1
Rosen RC, Fisher WA, Eardley I, Niederberger C, Nadel A, Sand M. The multinational men’s attitudes to life events and sexuality (MALES) study: I. Prevalence oSf erectile dysfunction and related health concerns in the general population. Curr Med Res Opin. 2004;20(5):607–17.
pubmed: 15171225
doi: 10.1185/030079904125003467
Schover LR. Sexual quality of life in men and women after cancer. Climacteric. 2019;22(6):553–7.
pubmed: 30380961
doi: 10.1080/13697137.2018.1526893
Loi M, Wortel RC, Francolini G, Incrocci L. Sexual function in patients treated with stereotactic radiotherapy for prostate cancer: a systematic review of the current evidence. J Sex Med. 2019;16(9):1409–20.
pubmed: 31303575
doi: 10.1016/j.jsxm.2019.05.019
Rosen RC, Riley A, Wagner G, Osterloh IH, Kirkpatrick J, Mishra A. The international index of erectile function (IIEF): a multidimensional scale for assessment of erectile dysfunction. Urology. 1997;49(6):822–30.
pubmed: 9187685
doi: 10.1016/S0090-4295(97)00238-0
Thomas HN, Thurston RC. A biopsychosocial approach to women’s sexual function and dysfunction at midlife: a narrative review. Maturitas. 2016;87:49–60.
pubmed: 27013288
pmcid: 4808247
doi: 10.1016/j.maturitas.2016.02.009
Barbera L, Zwaal C, Elterman D, McPherson K, Wolfman W, Katz A, et al. Interventions to address sexual problems in people with cancer. Curr Oncol. 2017;24(3):192–200.
pubmed: 28680280
pmcid: 5486385
doi: 10.3747/co.24.3583
Carter J, Lacchetti C, Andersen BL, Barton DL, Bolte S, Damast S, et al. Interventions to address sexual problems in people with cancer: American society of clinical oncology clinical practice guideline adaptation of cancer care ontario guideline. J Clin Oncol. 2018;36(5):492–511.
pubmed: 29227723
doi: 10.1200/JCO.2017.75.8995
Stephenson RA, Mori M, Hsieh YC, Beer TM, Stanford JL, Gilliland FD, et al. Treatment of erectile dysfunction following therapy for clinically localized prostate cancer: patient reported use and outcomes from the surveillance, epidemiology, and end results prostate cancer outcomes study. J Urol. 2005;174(2):646–50.
pubmed: 16006930
doi: 10.1097/01.ju.0000165342.85300.14
Pang K, Pan D, Xu H, Ma Y, Wang J, Xu P, et al. Advances in physical diagnosis and treatment of male erectile dysfunction. Front Physiol. 2023;9:13.
Montorsi F, Padma-Nathan H, Glina S. Erectile function and assessments of erection hardness correlate positively with measures of emotional well-being, sexual satisfaction, and treatment satisfaction in men with erectile dysfunction treated with sildenafil citrate (Viagra
pubmed: 17011373
doi: 10.1016/j.urology.2006.06.027
Schover LR, Fouladi RT, Warneke CL, Neese L, Klein EA, Zippe C, et al. The use of treatments for erectile dysfunction among survivors of prostate carcinoma. Cancer. 2002;95(11):2397–407.
pubmed: 12436448
doi: 10.1002/cncr.10970
Miller DC, Wei JT, Dunn RL, Montie JE, Pimentel H, Sandler HM, et al. Use of medications or devices for erectile dysfunction among long-term prostate cancer treatment survivors: potential influence of sexual motivation and/or indifference. Urology. 2006;68(1):166–71.
pubmed: 16844457
doi: 10.1016/j.urology.2006.01.077
Brotto LA, Yule M, Breckon E. Psychological interventions for the sexual sequelae of cancer: a review of the literature. J Cancer Surviv. 2010;4(4):346–60.
pubmed: 20602188
doi: 10.1007/s11764-010-0132-z
Carter J, Goldfrank D, Schover LR. Simple strategies for vaginal health promotion in cancer survivors. J Sex Med. 2011;8(2):549–59.
pubmed: 20722792
doi: 10.1111/j.1743-6109.2010.01988.x
Denlinger CS, Carlson RW, Are M, Baker KS, Davis E, Edge SB, et al. Survivorship: sexual dysfunction (Female), version 1.2013. J Natl Compr Cancer Netw. 2014;12(2):184–92.
doi: 10.6004/jnccn.2014.0019
Caruso S, Intelisano G, Farina M, Di Mari L, Agnello C. The function of sildenafil on female sexual pathways: a double-blind, cross-over, placebo-controlled study. Eur J Obstet Gynecol Reprod Biol. 2003;110(2):201–6.
pubmed: 12969584
doi: 10.1016/S0301-2115(03)00118-0
Caruso S, Intelisano G, Lupo L, Agnello C. Premenopausal women affected by sexual arousal disorder treated with sildenafil: a double-blind, cross-over, placebo-controlled study. BJOG. 2001;108(6):623–8.
pubmed: 11426898
Lindau ST, Gavrilova N. Sex, health, and years of sexually active life gained due to good health: evidence from two US population based cross sectional surveys of ageing. BMJ. 2010;340(mar09 2):c810–c810.
pubmed: 20215365
pmcid: 2835854
doi: 10.1136/bmj.c810
Ratner ES, Foran KA, Schwartz PE, Minkin MJ. Sexuality and intimacy after gynecological cancer. Maturitas. 2010;66(1):23–6.
pubmed: 20303222
doi: 10.1016/j.maturitas.2010.01.015
Bernard S, Tandon P, Waters A, Selmani S, Wiebe E, Turner J, et al. Preferences, barriers and facilitators regarding virtual pelvic healthcare in individuals with gynaecological cancers: protocol for a patient-oriented, mixed-methods study. BMJ Open. 2023;13(1): e067606.
pubmed: 36697045
pmcid: 9884898
doi: 10.1136/bmjopen-2022-067606
Venkataramu V, Ghotra H, Chaturvedi S. Management of psychiatric disorders in patients with cancer. Indian J Psychiatry. 2022;64(8):458.
doi: 10.4103/indianjpsychiatry.indianjpsychiatry_15_22
Arthur EK, Menon U, Reese JB, Browning K, Overcash J, Rose K, et al. Profiles of women’s adjustment after cancer based on sexual and psychosocial wellbeing: results of a cluster analysis. BMC Cancer. 2022;22(1):1003.
pubmed: 36131276
pmcid: 9491007
doi: 10.1186/s12885-022-10093-6