Deciphering the Timing of Naphthalenic Ring Formation in the Biosynthesis of 8-Deoxyrifamycins.

Naphthalenes Benzene

Journal

Organic letters
ISSN: 1523-7052
Titre abrégé: Org Lett
Pays: United States
ID NLM: 100890393

Informations de publication

Date de publication:
08 09 2023
Historique:
medline: 11 9 2023
pubmed: 27 8 2023
entrez: 27 8 2023
Statut: ppublish

Résumé

Although the biosynthesis of rifamycin has been studied for three decades, the biosynthetic formation of the naphthalenic ring remains unclear. In this study, by deletion of all post-PKS modification genes, we identified macrolactam precursors released from

Identifiants

DOI: 10.1021/acs.orglett.3c02039 PMID: 37634191
pubmed: 37634191
doi: 10.1021/acs.orglett.3c02039
doi:

Substances chimiques

naphthalene 2166IN72UN
Naphthalenes 0
Benzene J64922108F

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

6474-6478

Auteurs

Feng Ye (F)

Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, Shandong 250012, China.

Xia Zhao (X)

School of Chemistry and Chemical Engineering, Shandong University, Jinan, Shandong 250100, China.

Yanrong Shi (Y)

Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, Shandong 250012, China.

Yanlei Hu (Y)

School of Chemistry and Chemical Engineering, Shandong University, Jinan, Shandong 250100, China.

Yanjiao Ding (Y)

Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, Shandong 250012, China.

Chunhua Lu (C)

Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, Shandong 250012, China.
ORCID: 0000-0002-3261-1020

Yaoyao Li (Y)

Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, Shandong 250012, China.
ORCID: 0000-0002-8762-9615

Haoxin Wang (H)

State Key Laboratory of Microbial Technology, Shandong University, Qingdao, Shandong 266237, China.
ORCID: 0000-0002-1779-0286

Gang Lu (G)

School of Chemistry and Chemical Engineering, Shandong University, Jinan, Shandong 250100, China.
ORCID: 0000-0002-7319-4315

Yuemao Shen (Y)

Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, Shandong 250012, China.
State Key Laboratory of Microbial Technology, Shandong University, Qingdao, Shandong 266237, China.
ORCID: 0000-0002-3881-0135

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Classifications MeSH

questionsmedicales.fr › Composés polycycliques › Hydrocarbures aromatiques polycycliques › Naphtalènes › Deciphering the Timing of Naphthalenic Ring...
questionsmedicales.fr › Composés chimiques organiques › Hydrocarbures › Hydrocarbures cycliques › Hydrocarbures aromatiques › Dérivés du benzène › Benzène › Deciphering the Timing of Naphthalenic Ring...