Local Delivery of Nimustine Hydrochloride against Brain Tumors: Basic Characterization Study.

Rats Animals Nimustine / therapeutic use Transforming Growth Factor beta1 Rats, Inbred F344 Drug Delivery Systems / methods Brain Neoplasms / drug therapy Antineoplastic Agents / pharmacology Tumor Microenvironment
convection-enhanced delivery glioma immunostimulation nimustine hydrochloride pharmacokinetics

Journal

The Tohoku journal of experimental medicine
ISSN: 1349-3329
Titre abrégé: Tohoku J Exp Med
Pays: Japan
ID NLM: 0417355

Informations de publication

Date de publication:
11 Nov 2023
Historique:
medline: 14 11 2023
pubmed: 28 8 2023
entrez: 27 8 2023
Statut: ppublish

Résumé

Convection-enhanced delivery (CED) delivers agents directly into tumors and the surrounding parenchyma. Although a promising concept, clinical applications are often hampered by insufficient treatment efficacy. Toward developing an effective CED-based strategy for delivering drugs with proven clinical efficacy, we performed a basic characterization study to explore the locally delivered characteristics of the water soluble nitrosourea nimustine hydrochloride (ACNU). First, ACNU distribution after CED in rodent brain was studied using mass spectrometry imaging. Clearance of

Identifiants

DOI: 10.1620/tjem.2023.J069 PMID: 37635063
pubmed: 37635063
doi: 10.1620/tjem.2023.J069
doi:

Substances chimiques

Nimustine 0S726V972K
Transforming Growth Factor beta1 0
Antineoplastic Agents 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

187-194

Auteurs

Xiaodong Shao (X)

Department of Neurosurgery, Tohoku University Graduate School of Medicine.

Ryuta Saito (R)

Department of Neurosurgery, Tohoku University Graduate School of Medicine.
Department of Neurosurgery, Nagoya University Graduate School of Medicine.

Aya Sato (A)

Department of Neurosurgery, Tohoku University Graduate School of Medicine.

Saori Okuno (S)

Department of Neurosurgery, Tohoku University Graduate School of Medicine.

Daisuke Saigusa (D)

Faculty of Pharma-Science, Teikyo University.
Department of Medical Biochemistry, Tohoku University Graduate School of Medicine.
Department of Integrative Genomics, Tohoku Medical Megabank Organization, Tohoku University.

Ritsumi Saito (R)

Department of Medical Biochemistry, Tohoku University Graduate School of Medicine.
Department of Integrative Genomics, Tohoku Medical Megabank Organization, Tohoku University.

Akira Uruno (A)

Department of Medical Biochemistry, Tohoku University Graduate School of Medicine.
Department of Integrative Genomics, Tohoku Medical Megabank Organization, Tohoku University.

Yoshinari Osada (Y)

Department of Neurosurgery, Tohoku University Graduate School of Medicine.

Masayuki Kanamori (M)

Department of Neurosurgery, Tohoku University Graduate School of Medicine.

Teiji Tominaga (T)

Department of Neurosurgery, Tohoku University Graduate School of Medicine.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Rats › Local Delivery of Nimustine Hydrochloride...
questionsmedicales.fr › Eucaryotes › Animaux › Local Delivery of Nimustine Hydrochloride...
questionsmedicales.fr › Composés chimiques organiques › Composés nitrosés › Nitrosourées › Nimustine › Local Delivery of Nimustine Hydrochloride...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Protéines de la superfamille du TGF bêta › Facteur de croissance transformant bêta › Facteur de croissance transformant bêta-1 › Local Delivery of Nimustine Hydrochloride...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Rats › Lignées consanguines de rats › Rats de lignée F344 › Local Delivery of Nimustine Hydrochloride...
questionsmedicales.fr › Thérapeutique › Traitement médicamenteux › Systèmes de délivrance de médicaments › Local Delivery of Nimustine Hydrochloride...
questionsmedicales.fr › Maladies du système nerveux › Tumeurs du système nerveux › Tumeurs du système nerveux central › Tumeurs du cerveau › Local Delivery of Nimustine Hydrochloride...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Antinéoplasiques › Local Delivery of Nimustine Hydrochloride...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Microenvironnement cellulaire › Microenvironnement tumoral › Local Delivery of Nimustine Hydrochloride...