The effects of exercise training on insulin resistance in children and adolescents with overweight or obesity: a systematic review and meta-analysis.
adolescents
children
exercise training
insulin resistance
obesity
Journal
Frontiers in endocrinology
ISSN: 1664-2392
Titre abrégé: Front Endocrinol (Lausanne)
Pays: Switzerland
ID NLM: 101555782
Informations de publication
Date de publication:
2023
2023
Historique:
received:
02
03
2023
accepted:
03
05
2023
medline:
29
8
2023
pubmed:
28
8
2023
entrez:
28
8
2023
Statut:
epublish
Résumé
The aim of present meta-analysis was to determine the effects of exercise training (Exe) on insulin resistance (IR) and body weight in children and adolescents with overweight or obesity. PubMed, Web of Science, and Scopus were searched for original articles, published through October 2022 that included exercise versus control interventions on fasting glucose, insulin, HOMA-IR, and body weight outcomes in children and adolescents with overweight or obesity. Standardized mean differences (SMD) for fasting insulin, and weighted mean differences (WMD) for fasting glucose, HOMA-IR, body weight (BW), and 95% confidence intervals were determined using random effects models. Thirty-five studies comprising 1,550 children and adolescents with overweight and obesity were included in the present meta-analysis. Exercise training reduced fasting glucose (WMD=-2.52 mg/dL, p=0.001), fasting insulin (SMD=-0.77, p=0.001), HOMA-IR (WMD=-0.82, p=0.001), and BW (WMD=-1.51 kg, p=0.001), as compared to a control. Subgroup analyses showed that biological sex, intervention duration, type of exercise training, BMI percentile, and health status (with or without diagnosed condition), were sources of heterogeneity. Exercise training is effective for lowering fasting glucose, fasting insulin, HOMA-IR, and BW in children and adolescents with overweight or obesity and could provide an important strategy for controlling IR and related factors. With clear evidence for the effectiveness of exercise interventions in this vulnerable population, it is important to determine effective approaches for increasing exercise training in children and adolescents with overweight or obesity.
Identifiants
pubmed: 37635963
doi: 10.3389/fendo.2023.1178376
pmc: PMC10450243
doi:
Substances chimiques
Glucose
IY9XDZ35W2
Insulin
0
Types de publication
Journal Article
Meta-Analysis
Systematic Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
1178376Informations de copyright
Copyright © 2023 Kazeminasab, Sharafifard, Miraghajani, Behzadnejad and Rosenkranz.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
J Nutr Biochem. 2011 Nov;22(11):1030-4
pubmed: 21216583
Br J Sports Med. 2011 Sep;45(11):866-70
pubmed: 21836171
J Pediatr Endocrinol Metab. 2020 Jan 28;33(1):129-137
pubmed: 31812946
J Pediatr. 2004 Dec;145(6):731-6
pubmed: 15580192
Horm Mol Biol Clin Investig. 2019 Oct 16;40(3):
pubmed: 31618176
Chin Med J (Engl). 2011 Feb;124(3):323-9
pubmed: 21362327
J Am Coll Cardiol. 2009 Dec 15;54(25):2396-406
pubmed: 20082930
Appl Physiol Nutr Metab. 2021 Jun;46(6):561-570
pubmed: 33151749
J Pediatr Endocrinol Metab. 2018 Jan 26;31(2):127-135
pubmed: 29306931
Sports Med. 2018 Mar;48(3):733-746
pubmed: 28853029
J Pediatr Endocrinol Metab. 2010 Oct;23(10):1065-72
pubmed: 21158218
J Pediatr Endocrinol Metab. 2019 Oct 25;32(10):1121-1129
pubmed: 31539362
J Cell Physiol. 2019 Jun;234(6):8152-8161
pubmed: 30317615
Prev Med. 2016 Dec;93:211-218
pubmed: 27773709
Ann Intern Med. 2009 Aug 18;151(4):264-9, W64
pubmed: 19622511
Public Health Nurs. 2021 May;38(3):502-516
pubmed: 33569831
Clin Exp Hypertens. 2017;39(6):546-552
pubmed: 28590143
Pediatr Obes. 2014 Aug;9(4):281-91
pubmed: 23801526
J Cell Physiol. 2019 Aug;234(8):12385-12392
pubmed: 30605232
Korean J Physiol Pharmacol. 2012 Jun;16(3):175-80
pubmed: 22802698
Curr Opin Endocrinol Diabetes Obes. 2014 Oct;21(5):313-22
pubmed: 25105998
Clin Rehabil. 2014 Mar;28(3):221-31
pubmed: 23963438
Med Sci Sports Exerc. 2009 Jul;41(7):1494-503
pubmed: 19516150
J Am Coll Cardiol. 2006 Nov 7;48(9):1865-70
pubmed: 17084264
Curr Opin Pediatr. 2020 Aug;32(4):582-588
pubmed: 32520824
BMC Med Res Methodol. 2014 Dec 19;14:135
pubmed: 25524443
Int J Obes (Lond). 2008 Jun;32(6):1016-27
pubmed: 18283282
Diabetes. 2012 Nov;61(11):2787-95
pubmed: 22751691
BMC Pediatr. 2022 Mar 1;22(1):112
pubmed: 35232402
Int J Pediatr Obes. 2009;4(4):205-14
pubmed: 19922034
Eur J Appl Physiol. 2013 Oct;113(10):2531-40
pubmed: 23824463
Phytother Res. 2019 May;33(5):1246-1257
pubmed: 30838686
BMC Med Res Methodol. 2005 Apr 20;5:13
pubmed: 15840177
Front Endocrinol (Lausanne). 2021 Dec 03;12:773820
pubmed: 34925239
Diabetes Metab Syndr Obes. 2021 Mar 04;14:991-1010
pubmed: 33692630
Horm Mol Biol Clin Investig. 2020 Nov 25;41(4):
pubmed: 33581014
Healthcare (Basel). 2022 Jan 01;10(1):
pubmed: 35052246
J Pediatr (Rio J). 2014 Nov-Dec;90(6):600-7
pubmed: 25019650
Cochrane Database Syst Rev. 2019 Oct 3;10:ED000142
pubmed: 31643080
BMJ. 1997 Sep 13;315(7109):629-34
pubmed: 9310563
Nutrients. 2020 May 03;12(5):
pubmed: 32375231
BMJ Open. 2019 Nov 11;9(11):e031220
pubmed: 31719081
Med Sci Sports Exerc. 2011 Nov;43(11):2195-203
pubmed: 21502883
Appl Physiol Nutr Metab. 2016 Jan;41(1):103-9
pubmed: 26701117
Diabet Med. 2014 Oct;31(10):1163-73
pubmed: 24965376
J Sports Sci. 2016;34(6):564-75
pubmed: 26208409
Pediatr Exerc Sci. 2018 Nov 1;30(4):480-486
pubmed: 30193554
BMC Pediatr. 2019 Jan 8;19(1):12
pubmed: 30621667
Sports Med. 2005;35(5):375-92
pubmed: 15896088
Crit Rev Food Sci Nutr. 2019;59(13):2028-2039
pubmed: 29400991
Rev Endocr Metab Disord. 2006 Sep;7(3):141-7
pubmed: 17165145
J Int Med Res. 2009 Sep-Oct;37(5):1472-8
pubmed: 19930853
Nutr Health. 2017 Dec;23(4):281-288
pubmed: 29214926
J Sports Sci. 2016 Oct;34(20):1902-12
pubmed: 26852885
Appl Physiol Nutr Metab. 2020 Mar;45(3):294-300
pubmed: 31386826
Am J Physiol Endocrinol Metab. 2013 Nov 15;305(10):E1222-9
pubmed: 24045865
Phys Sportsmed. 2016 Nov;44(4):355-361
pubmed: 27737602
Medicine (Baltimore). 2019 Jan;98(4):e14249
pubmed: 30681616
Circ Res. 2020 May 22;126(11):1549-1564
pubmed: 32437299
Int J Environ Res Public Health. 2021 Nov 12;18(22):
pubmed: 34831659
Children (Basel). 2022 Jul 01;9(7):
pubmed: 35883978
Biomed Pharmacother. 2021 May;137:111315
pubmed: 33561645