Lytic efficiency of immunosuppressive drug-resistant armoured T cells against circulating HBV-related HCC in whole blood.
HBV
TCR T cells
adoptive T-cell transfer
circulating tumour cells
hepatocellular carcinoma
Journal
Immunotherapy advances
ISSN: 2732-4303
Titre abrégé: Immunother Adv
Pays: England
ID NLM: 101776979
Informations de publication
Date de publication:
2023
2023
Historique:
received:
12
04
2023
accepted:
10
08
2023
medline:
28
8
2023
pubmed:
28
8
2023
entrez:
28
8
2023
Statut:
epublish
Résumé
Recurrence of hepatitis B virus-related hepatocellular carcinoma (HBV-HCC) after liver transplant (LT) is mediated by circulating tumour cells (CTCs) and exacerbated by the immunosuppressants required to prevent graft rejection. To circumvent the effects of immunosuppressants, we developed immunosuppressive drug-resistant armoured HBV-specific T-cell receptor-redirected T cells (IDRA HBV-TCR). However, their ability to eliminate HBV-HCC circulating in the whole blood has never been tested, and whether their lytic efficacy is compatible with the number of adoptively transferred T cells
Identifiants
pubmed: 37636242
doi: 10.1093/immadv/ltad015
pii: ltad015
pmc: PMC10460197
doi:
Types de publication
Journal Article
Langues
eng
Pagination
ltad015Informations de copyright
© The Author(s) 2023. Published by Oxford University Press on behalf of the British Society for Immunology.
Déclaration de conflit d'intérêts
S.C.B. owns stock in and receives compensation from X-Zell, a company owning patents and commercialising technologies covering rare-cell detection and characterisation. A.P. is a consultant and shareholder of AIM Biotech Pte. Ltd. A.B. and A.T.T. are the Scientific Founder and the Scientific Consultant of Lion TCR Pte. Ltd, respectively, a biotech company developing T-cell receptors for the treatment of virus-related diseases and cancers. All other authors disclose no conflicts.
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