Relationship between patient sex and anatomical sites of extrapulmonary tuberculosis in Mali.

Africa Disease Gender Localization Mycobacterium

Journal

Journal of clinical tuberculosis and other mycobacterial diseases
ISSN: 2405-5794
Titre abrégé: J Clin Tuberc Other Mycobact Dis
Pays: England
ID NLM: 101682877

Informations de publication

Date de publication:
Dec 2023
Historique:
medline: 28 8 2023
pubmed: 28 8 2023
entrez: 28 8 2023
Statut: epublish

Résumé

Contribution of host factors in mediating susceptibility to extrapulmonary tuberculosis is not well understood. To examine the influence of patient sex on anatomical localization of extrapulmonary tuberculosis. We conducted a retrospective cross-sectional study in Mali, West Africa. Hospital records of 1,304 suspected cases of extrapulmonary tuberculosis, available in TB Registry of a tertiary tuberculosis referral center from 2019 to 2021, were examined. A total of 1,012 (77.6%) were confirmed to have extrapulmonary tuberculosis with a male to female ratio of 1.59:1. Four clinical forms of EPTB predominated, namely pleural (40.4%), osteoarticular (29.8%), lymph node (12.5%), and abdominal TB (10.3%). We found sex-based differences in anatomical localization of extrapulmonary tuberculosis, with males more likely than females to have pleural TB (OR: 1.51; 95% CI [1.16 to 1.98]). Conversely, being male was associated with 43% and 41% lower odds of having lymph node and abdominal TB, respectively (OR: 0.57 and 0.59). Anatomical sites of extrapulmonary tuberculosis differ by sex with pleural TB being associated with male sex while lymph node and abdominal TB are predominately associated with female sex. Future studies are warranted to understand the role of sex in mediating anatomical site preference of tuberculosis.

Sections du résumé

Background UNASSIGNED
Contribution of host factors in mediating susceptibility to extrapulmonary tuberculosis is not well understood.
Objective UNASSIGNED
To examine the influence of patient sex on anatomical localization of extrapulmonary tuberculosis.
Methods UNASSIGNED
We conducted a retrospective cross-sectional study in Mali, West Africa. Hospital records of 1,304 suspected cases of extrapulmonary tuberculosis, available in TB Registry of a tertiary tuberculosis referral center from 2019 to 2021, were examined.
Results UNASSIGNED
A total of 1,012 (77.6%) were confirmed to have extrapulmonary tuberculosis with a male to female ratio of 1.59:1. Four clinical forms of EPTB predominated, namely pleural (40.4%), osteoarticular (29.8%), lymph node (12.5%), and abdominal TB (10.3%). We found sex-based differences in anatomical localization of extrapulmonary tuberculosis, with males more likely than females to have pleural TB (OR: 1.51; 95% CI [1.16 to 1.98]). Conversely, being male was associated with 43% and 41% lower odds of having lymph node and abdominal TB, respectively (OR: 0.57 and 0.59).
Conclusion UNASSIGNED
Anatomical sites of extrapulmonary tuberculosis differ by sex with pleural TB being associated with male sex while lymph node and abdominal TB are predominately associated with female sex. Future studies are warranted to understand the role of sex in mediating anatomical site preference of tuberculosis.

Identifiants

DOI: 10.1016/j.jctube.2023.100389 PMID: 37637324 PMC: PMC10448223
pubmed: 37637324
doi: 10.1016/j.jctube.2023.100389
pii: S2405-5794(23)00045-1
pmc: PMC10448223
doi:

Types de publication

Journal Article

Langues

eng

Pagination

100389

Subventions

Organisme : FIC NIH HHS
ID : K43 TW011426
Pays : United States

Informations de copyright

© 2023 The Author(s).

Déclaration de conflit d'intérêts

The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

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Auteurs

Bocar Baya (B)

University Clinical Research Center (UCRC), Faculty of Pharmacy and Faculty of Medicine and Odonto-Stomatology, University of Sciences, Techniques, and Technologies of Bamako (USTTB), Mali, West Africa.
Department of Pneumophtisiology, University Teaching Hospital of Point-G, Faculty of Medicine and Odonto-Stomatology, University of Sciences, Techniques, and Technologies of Bamako (USTTB), Mali, West Africa.

Ibrahim Sanogo (I)

University Clinical Research Center (UCRC), Faculty of Pharmacy and Faculty of Medicine and Odonto-Stomatology, University of Sciences, Techniques, and Technologies of Bamako (USTTB), Mali, West Africa.

Mahamadou Kone (M)

University Clinical Research Center (UCRC), Faculty of Pharmacy and Faculty of Medicine and Odonto-Stomatology, University of Sciences, Techniques, and Technologies of Bamako (USTTB), Mali, West Africa.

Dianguina Soumare (D)

Department of Pneumophtisiology, University Teaching Hospital of Point-G, Faculty of Medicine and Odonto-Stomatology, University of Sciences, Techniques, and Technologies of Bamako (USTTB), Mali, West Africa.

Kadidia Ouattara (K)

Department of Pneumophtisiology, University Teaching Hospital of Point-G, Faculty of Medicine and Odonto-Stomatology, University of Sciences, Techniques, and Technologies of Bamako (USTTB), Mali, West Africa.

Amadou Somboro (A)

University Clinical Research Center (UCRC), Faculty of Pharmacy and Faculty of Medicine and Odonto-Stomatology, University of Sciences, Techniques, and Technologies of Bamako (USTTB), Mali, West Africa.

Mamadou Wague (M)

University Clinical Research Center (UCRC), Faculty of Pharmacy and Faculty of Medicine and Odonto-Stomatology, University of Sciences, Techniques, and Technologies of Bamako (USTTB), Mali, West Africa.

Nadie Coulibaly (N)

University Clinical Research Center (UCRC), Faculty of Pharmacy and Faculty of Medicine and Odonto-Stomatology, University of Sciences, Techniques, and Technologies of Bamako (USTTB), Mali, West Africa.

Isaac Koloma (I)

University Clinical Research Center (UCRC), Faculty of Pharmacy and Faculty of Medicine and Odonto-Stomatology, University of Sciences, Techniques, and Technologies of Bamako (USTTB), Mali, West Africa.

Mariam Coulibaly (M)

University Clinical Research Center (UCRC), Faculty of Pharmacy and Faculty of Medicine and Odonto-Stomatology, University of Sciences, Techniques, and Technologies of Bamako (USTTB), Mali, West Africa.

Mohamed Nantoume (M)

University Clinical Research Center (UCRC), Faculty of Pharmacy and Faculty of Medicine and Odonto-Stomatology, University of Sciences, Techniques, and Technologies of Bamako (USTTB), Mali, West Africa.

Mamadou Perou (M)

University Clinical Research Center (UCRC), Faculty of Pharmacy and Faculty of Medicine and Odonto-Stomatology, University of Sciences, Techniques, and Technologies of Bamako (USTTB), Mali, West Africa.

Kadidia Kone (K)

University Clinical Research Center (UCRC), Faculty of Pharmacy and Faculty of Medicine and Odonto-Stomatology, University of Sciences, Techniques, and Technologies of Bamako (USTTB), Mali, West Africa.

Djeneba Coulibaly (D)

University Clinical Research Center (UCRC), Faculty of Pharmacy and Faculty of Medicine and Odonto-Stomatology, University of Sciences, Techniques, and Technologies of Bamako (USTTB), Mali, West Africa.

Hawa Boukary Diarra (H)

University Clinical Research Center (UCRC), Faculty of Pharmacy and Faculty of Medicine and Odonto-Stomatology, University of Sciences, Techniques, and Technologies of Bamako (USTTB), Mali, West Africa.

Bourahima Kone (B)

University Clinical Research Center (UCRC), Faculty of Pharmacy and Faculty of Medicine and Odonto-Stomatology, University of Sciences, Techniques, and Technologies of Bamako (USTTB), Mali, West Africa.

Ayouba Diarra (A)

University Clinical Research Center (UCRC), Faculty of Pharmacy and Faculty of Medicine and Odonto-Stomatology, University of Sciences, Techniques, and Technologies of Bamako (USTTB), Mali, West Africa.

Mamadou D Coulibaly (MD)

University Clinical Research Center (UCRC), Faculty of Pharmacy and Faculty of Medicine and Odonto-Stomatology, University of Sciences, Techniques, and Technologies of Bamako (USTTB), Mali, West Africa.

Moumine Sanogo (M)

University Clinical Research Center (UCRC), Faculty of Pharmacy and Faculty of Medicine and Odonto-Stomatology, University of Sciences, Techniques, and Technologies of Bamako (USTTB), Mali, West Africa.

Bassirou Diarra (B)

University Clinical Research Center (UCRC), Faculty of Pharmacy and Faculty of Medicine and Odonto-Stomatology, University of Sciences, Techniques, and Technologies of Bamako (USTTB), Mali, West Africa.

Mahamadou Diakite (M)

University Clinical Research Center (UCRC), Faculty of Pharmacy and Faculty of Medicine and Odonto-Stomatology, University of Sciences, Techniques, and Technologies of Bamako (USTTB), Mali, West Africa.

Chad J Achenbach (CJ)

Northwestern University (NU), Division of Infectious Diseases and Havey Institute for Global Health, Feinberg School of Medicine, Chicago, IL, USA.

Seydou Doumbia (S)

University Clinical Research Center (UCRC), Faculty of Pharmacy and Faculty of Medicine and Odonto-Stomatology, University of Sciences, Techniques, and Technologies of Bamako (USTTB), Mali, West Africa.

William R Bishai (WR)

Johns Hopkins School of Medicine, Department of Infectious Diseases, Center for Tuberculosis Research, Baltimore, MD, USA.

Sabra L Klein (SL)

Johns Hopkins Bloomberg School of Public Health, W. Harry Feinstone Department of Molecular Microbiology and Immunology, Baltimore, MD, USA.

Jane L Holl (JL)

University of Chicago, Biological Sciences Division, Chicago, IL, USA.

Souleymane Diallo (S)

University Clinical Research Center (UCRC), Faculty of Pharmacy and Faculty of Medicine and Odonto-Stomatology, University of Sciences, Techniques, and Technologies of Bamako (USTTB), Mali, West Africa.

Robert L Murphy (RL)

Northwestern University (NU), Division of Infectious Diseases and Havey Institute for Global Health, Feinberg School of Medicine, Chicago, IL, USA.
University of Chicago, Biological Sciences Division, Chicago, IL, USA.

Yacouba Toloba (Y)

University Clinical Research Center (UCRC), Faculty of Pharmacy and Faculty of Medicine and Odonto-Stomatology, University of Sciences, Techniques, and Technologies of Bamako (USTTB), Mali, West Africa.
Department of Pneumophtisiology, University Teaching Hospital of Point-G, Faculty of Medicine and Odonto-Stomatology, University of Sciences, Techniques, and Technologies of Bamako (USTTB), Mali, West Africa.

Djeneba Dabitao (D)

University Clinical Research Center (UCRC), Faculty of Pharmacy and Faculty of Medicine and Odonto-Stomatology, University of Sciences, Techniques, and Technologies of Bamako (USTTB), Mali, West Africa.

Classifications MeSH