Fc multimers effectively treat murine models of multiple sclerosis.

Animals Mice Multiple Sclerosis / drug therapy Disease Models, Animal Neurodegenerative Diseases Receptors, IgG Encephalomyelitis, Autoimmune, Experimental
EAE FC autoimmunity multiple sclerosis therapeutic

Journal

Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960

Informations de publication

Date de publication:
2023
Historique:
received: 03 04 2023
accepted: 25 07 2023
medline: 29 8 2023
pubmed: 28 8 2023
entrez: 28 8 2023
Statut: epublish

Résumé

Multiple Sclerosis (MS) is a chronic neurodegenerative disease with limited therapeutic options. Recombinant Fc multimers (rFc), designed to mirror many of the anti-inflammatory activities of Intravenous Immunoglobulin (IVIG), have been shown to effectively treat numerous immune-mediated diseases in rodents. In this study we used the experimental autoimmune encephalomyelitis (EAE) murine model of MS to test the efficacy of a rFc, M019, that consists of multimers of the Fc portion of IgG2, in inhibiting disease severity. We show that M019 effectively reduced clinical symptoms when given either pre- or post-symptom onset compared to vehicle treated EAE induced mice. M019 was effective in reducing symptoms in both SJL model of relapsing remitting MS as well as the B6 model of chronic disease. M019 binds to FcγR bearing-monocytes both

Identifiants

DOI: 10.3389/fimmu.2023.1199747 PMID: 37638040 PMC: PMC10451071
pubmed: 37638040
doi: 10.3389/fimmu.2023.1199747
pmc: PMC10451071
doi:

Substances chimiques

Receptors, IgG 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

1199747

Informations de copyright

Copyright © 2023 Wang, Brown, Danehy, Mérigeon, Goralski, Rice, Torgbe, Thomas, Block, Olsen, Strome and Fitzpatrick.

Déclaration de conflit d'intérêts

SS is a cofounder, stockholder and paid consultant of Gliknik Inc. DB, HO, EM, and SG are Gliknik employees. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be constructed as a potential conflict of interest.

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Auteurs

Jin Wang (J)

Dept. of Microbiology Immunology and Biochemistry, UTHSC, Memphis, TN, United States.

Kellie Brown (K)

Dept. of Microbiology Immunology and Biochemistry, UTHSC, Memphis, TN, United States.

Caroline Danehy (C)

College of Graduate Health Sciences, UTHSC, Memphis, TN, United States.

Emmanuel Mérigeon (E)

Gliknik, Inc., Baltimore, MD, United States.

Stephen Goralski (S)

Gliknik, Inc., Baltimore, MD, United States.

Samuel Rice (S)

College of Medicine, UTHSC, Memphis, TN, United States.

Kwame Torgbe (K)

Dept. of Pathology, UTHSC, Memphis, TN, United States.

Fridtjof Thomas (F)

Div. of Biostatistics, Dept. of Preventive Medicine, UTHSC, Memphis, TN, United States.

David Block (D)

Gliknik, Inc., Baltimore, MD, United States.

Henrik Olsen (H)

Gliknik, Inc., Baltimore, MD, United States.

Scott E Strome (SE)

Dept. of Microbiology Immunology and Biochemistry, UTHSC, Memphis, TN, United States.

Elizabeth A Fitzpatrick (EA)

Dept. of Microbiology Immunology and Biochemistry, UTHSC, Memphis, TN, United States.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Fc multimers effectively treat murine models...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Fc multimers effectively treat murine models...
questionsmedicales.fr › Maladies du système immunitaire › Maladies auto-immunes › Maladies auto-immunes du système nerveux › Maladies démyélinisantes auto-immunes du SNC › Sclérose en plaques › Fc multimers effectively treat murine models...
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles biologiques › Modèles animaux de maladie humaine › Fc multimers effectively treat murine models...
questionsmedicales.fr › Maladies du système nerveux › Maladies neurodégénératives › Fc multimers effectively treat murine models...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs immunologiques › Récepteur Fc › Récepteurs du fragment Fc des IgG › Fc multimers effectively treat murine models...
questionsmedicales.fr › Techniques d'investigation › Modèles animaux › Maladie neurologique auto-immune expérimentale › Encéphalomyélite auto-immune expérimentale › Fc multimers effectively treat murine models...