Adamantyl-ureas with pyrazoles substituted by fluoroalkanes as soluble epoxide hydrolase inhibitors.
adamantane
halogenated pyrazoles
inhibitor
soluble epoxide hydrolase
urea
Journal
Journal of fluorine chemistry
ISSN: 0022-1139
Titre abrégé: J Fluor Chem
Pays: United States
ID NLM: 0373322
Informations de publication
Date de publication:
Feb 2023
Feb 2023
Historique:
pmc-release:
01
02
2024
medline:
28
8
2023
pubmed:
28
8
2023
entrez:
28
8
2023
Statut:
ppublish
Résumé
A series of soluble epoxide hydrolase (sEH) inhibitors containing halogenated pyrazoles was developed. Inhibition potency of the obtained compounds ranges from 0.8 to 27.5 nM. 1-Adamantyl-3-[(4,5-dichloro-1-methyl-1Н-pyrazol-3-yl)methyl]urea (
Identifiants
pubmed: 37638129
doi: 10.1016/j.jfluchem.2023.110087
pmc: PMC10457016
mid: NIHMS1868991
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : NIEHS NIH HHS
ID : R35 ES030443
Pays : United States
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