Dermatological manifestations associated with COVID-19 and COVID-19 vaccination: results from the Lebanese COVID registry.
Journal
International journal of dermatology
ISSN: 1365-4632
Titre abrégé: Int J Dermatol
Pays: England
ID NLM: 0243704
Informations de publication
Date de publication:
Oct 2023
Oct 2023
Historique:
revised:
22
05
2023
received:
24
02
2023
accepted:
11
08
2023
medline:
20
9
2023
pubmed:
28
8
2023
entrez:
28
8
2023
Statut:
ppublish
Résumé
A number of cutaneous manifestations and adverse cutaneous reactions have been associated with COVID-19 infection and vaccine. A Lebanese national registry was established to characterize the dermatologic manifestations and adverse cutaneous reactions associated with COVID-19 infection and vaccination in a sample of the Lebanese population. An observational cross-sectional study was conducted via a web-based clinical form distributed to physicians wishing to report their cases from May 2021 till May 2022. In total, 142 patients were entered in the registry, of which 133 were adults and nine were pediatric patients. The main dermatological manifestations reported with COVID-19 infection in the adult group were urticaria (32.9%), telogen effluvium (21.4%), morbilliform (10%), and papulosquamous (8.6%) eruptions. Urticaria was the most common adverse cutaneous reaction to the vaccine (33%). Interestingly, herpes zoster was triggered in 12 patients post vaccination in our series with this finding more frequently seen in patients above the age of 41 (P = 0.013). In the pediatric group, the most reported dermatological findings associated with COVID-19 infection were malar erythema (25%) and telogen effluvium (25%). One 16-year-old patient developed lichen planus after one dose of a COVID-19 vaccine. No deaths were reported in both age groups. This Lebanese registry adds more robust evidence that clinical manifestations of the COVID-19 virus and vaccine are diverse. More studies are necessary to establish the pathophysiology of these dermatological findings in the context of COVID-19 infection and vaccination.
Sections du résumé
BACKGROUND
BACKGROUND
A number of cutaneous manifestations and adverse cutaneous reactions have been associated with COVID-19 infection and vaccine.
OBJECTIVES
OBJECTIVE
A Lebanese national registry was established to characterize the dermatologic manifestations and adverse cutaneous reactions associated with COVID-19 infection and vaccination in a sample of the Lebanese population.
METHODS
METHODS
An observational cross-sectional study was conducted via a web-based clinical form distributed to physicians wishing to report their cases from May 2021 till May 2022.
RESULTS
RESULTS
In total, 142 patients were entered in the registry, of which 133 were adults and nine were pediatric patients. The main dermatological manifestations reported with COVID-19 infection in the adult group were urticaria (32.9%), telogen effluvium (21.4%), morbilliform (10%), and papulosquamous (8.6%) eruptions. Urticaria was the most common adverse cutaneous reaction to the vaccine (33%). Interestingly, herpes zoster was triggered in 12 patients post vaccination in our series with this finding more frequently seen in patients above the age of 41 (P = 0.013). In the pediatric group, the most reported dermatological findings associated with COVID-19 infection were malar erythema (25%) and telogen effluvium (25%). One 16-year-old patient developed lichen planus after one dose of a COVID-19 vaccine. No deaths were reported in both age groups.
CONCLUSION
CONCLUSIONS
This Lebanese registry adds more robust evidence that clinical manifestations of the COVID-19 virus and vaccine are diverse. More studies are necessary to establish the pathophysiology of these dermatological findings in the context of COVID-19 infection and vaccination.
Substances chimiques
COVID-19 Vaccines
0
Types de publication
Observational Study
Case Reports
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1248-1256Subventions
Organisme : Lebanese American University
ID : SRRC-R-2020-238
Investigateurs
Salam Itani
(S)
Jihane Abou Rahal
(JA)
Grace Obeid
(G)
Nelly Rubeiz
(N)
Adele Chedrawi
(A)
Dana Saade
(D)
Abdul Ghani Kibbi
(AG)
Alfred Amoury
(A)
Farid Stephan
(F)
Josiane Helou
(J)
Roland Tomb
(R)
Pamela Chkaiban
(P)
Melissa Makhlouf
(M)
Joelle Feghali
(J)
Joy Assaf
(J)
Luciana Habr
(L)
Georgio Chidiac
(G)
Informations de copyright
© 2023 the International Society of Dermatology.
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